Dimethyl sulfate mutational profiling with sequencing, combined with the newly developed DREEM algorithm, reveals that heterogeneity of RNA structure in HIV-1 regulates the use of splice sites and expression of viral genes.
Now is not the time for Hollywood 'zoom and enhance' fantasies Be wary of medical scans enhanced by AI algorithms: the software is prone to making tiny errors that could lead to incorrect diagnoses, a study has warned.…
Cryo-electron microscopy reveals the structures of α-synuclein filaments from the brains of individuals with multiple system atrophy.
(Bloomberg) -- Nomura Holdings Inc. probably joined its Wall Street rivals in benefiting from a jump in trading during last quarter’s wild market swings, masking the challenge for its new chief as the coronavirus pandemic hammers the economy.Japan’s biggest brokerage is likely to post a fourth straight quarter of profit growth on Friday, helping full-year earnings climb to the highest in more than a decade, analysts at Jefferies and Mitsubishi UFJ Morgan Stanley Securities Co. predict. The trading boost is expected to make up for weakness in underwriting business as Japanese companies grew cautious in anticipation of a deep recession.Chief Executive Officer Kentaro Okuda may not be able to rely on the boom being sustained, with U.S. banks including Morgan Stanley warning that transaction volumes are waning. Okuda, who took the job on April 1, has vowed to persist with an overhaul that centers on bolstering advisory business for companies and revamping the struggling domestic retail franchise.Read more on Okuda’s tough initiation as CEONomura’s path from here could be “one step forward and three steps back,” said Bloomberg Intelligence analyst Shin Tamura. While corporate clients will rely on the firm to issue bonds to raise cash needed to survive the economic downturn, there may be less demand for equity underwriting, merger advisory and trading services, he said.Japanese equity offerings have plunged 63% so far in 2020 from a year earlier, while corporate bond issuances have slipped 2.3%, according to data compiled by Bloomberg. Mergers have dropped 17%, the figures show.Net income likely came to 35 billion yen ($329 million) in the three months ended March 31, up from less than 1 billion yen a year earlier, said Hideyasu Ban, an analyst at Jefferies. Mitsubishi UFJ Morgan Stanley’s Natsumu Tsujino expects profit of 30.1 billion yen.Nomura’s solid results in recent quarters -- coming after a rare annual loss in the previous year -- have been largely due to its trading desks even as the company’s restructuring emphasized a shift away from relying on such secondary business and toward advisory services. Okuda, whose background is in investment banking, announced the plan in April last year when he was co-chief operating officer.Worries over the pandemic whipsawed global markets in March, creating the most extreme swings in more than a decade. Wall Street banks gained an average 30% in trading revenues in the quarter.Nomura may have benefited from higher trading activity on the retail front too, if results of local rivals are any guide. Mizuho Securities Co. is among firms that reported increases in stock-transaction commissions from individual clients.But social distancing efforts in Japan are exposing the business models of traditional brokerages including Nomura, which have closed branch service counters during a national state of emergency. SMBC Nikko Securities Inc. said the halting of face-to-face contact with retail customers is having a large impact on its sales of products such as mutual funds.Shares of Nomura fell 2.5% on Thursday afternoon in Tokyo, extending this year’s decline to 24%.“As far as the outlook is concerned, no one can tell what’s going to happen to things like stock trading volumes once the market calms,” Jefferies’ Ban said. “Will there be more trading? Or things will become quiet? It’s impossible to tell yet.”(Updates with shares in the second-to-last paragraph)For more articles like this, please visit us at bloomberg.comSubscribe now to stay ahead with the most trusted business news source.©2020 Bloomberg L.P.
Nomura's (NMR) business strategy involves investments in private businesses and digitization in order to improve the company's prospects.
Japanese bank Nomura <8604.T> has strengthened its investment banking team in the Americas, making five senior appointments to expand its coverage across financial institutions, healthcare and industrials, the bank said on Friday. The appointments will also result in the bank increasing its range of products in private debt solutions, it said. Aaron Dannenberg, previously head of debt originations at Czech Asset Management, has joined Nomura as head of private debt solutions within the bank's client financing and solutions division, the bank said.
How do you pick the next stock to invest in? One way would be to spend days of research browsing through thousands of publicly traded companies. However, an easier way is to look at the stocks that smart money investors are collectively bullish on. Hedge funds and other institutional investors usually invest large amounts of […]
The re-emergence of facemask-wearing bankers, investors, lawyers and their clients in Central, Hong Kong's main business district, is being closely watched by other major financial centres looking forward to resuming business. Office staffing levels at the banks vary from around 50% to just 15%.
Repression of a messenger RNA by a cognate microRNA depends not only on complementary base pairing, but also on the rearrangement of a single base pair, producing a conformation that fits better within the human Ago2 protein.
Crystallographic ‘snapshots’ taken at intervals of femtoseconds to milliseconds after activation show how a light-activated sodium pump carries sodium ions across the cell membrane.
New research shows that an RNA molecule involved in preventing tumor formation can change its structure and thereby control protein production in the cell. The finding can have important clinical implications as it opens for new strategies to treat different …
Repression of a messenger RNA by a cognate microRNA depends not only on complementary base pairing, but also on the rearrangement of a single base pair, producing a conformation that fits better within the human Ago2 protein.
Here at Zacks, our focus is on the proven Zacks Rank system, which emphasizes earnings estimates and estimate revisions to find great stocks. Nevertheless, we are always paying attention to the latest value, growth, and momentum trends to underscore strong picks.
In sync with Goldman Sachs' (GS) efforts to gain majority control in the joint venture and improve profitability, the bank announces plans to increase workforce in China.
Nomura is poised to break with almost a century of tradition by unveiling a new strategic focus on private markets and Japan’s vast hinterland of unlisted companies. The move is part of a broader shake-up at Japan’s biggest brokerage to be announced this week by its new chief executive, Kentaro Okuda. Mr Okuda is the company’s first chief executive to have emerged from the investment banking division.
Good day everyone and welcome to today's Nomura Holdings Fourth Quarter and Full-Year Operating Results for Fiscal Year Ended March 2020 Conference Call. This slide outlines some of the initiatives we have undertaken to help our employees, clients and communities.
Moody's Japan K.K. has assigned a (P)Baa1 USD senior unsecured shelf registration of Nomura Holdings, Inc. (Nomura), and Baa1 rating to the senior unsecured bonds. Nomura's Baa1 senior unsecured bond rating is one notch lower than the A3 issuer rating we assign to Nomura Securities Co., Ltd. (Nomura Securities, A3 negative). Nomura is rated one notch lower than Nomura Securities because it is a holding company that depends on upstreamed dividends from its operating subsidiaries, mainly Nomura Securities.
Coronavirus is probably the 1 concern in investors' minds right now. It should be. On February 27th we published an article with the title Recession is Imminent: We Need A Travel Ban NOW. We predicted that a US recession is imminent and US stocks will go down by at least 20% in the next 3-6 […]
Cryo-electron microscopy reveals the structures of α-synuclein filaments from the brains of individuals with multiple system atrophy.
RNA in situ conformation sequencing (RIC-seq) enables the generation of three-dimensional interaction maps of RNA in cells, which sheds light on the interactions and regulatory functions of RNA.
RNA in situ conformation sequencing (RIC-seq) enables the generation of three-dimensional interaction maps of RNA in cells, which sheds light on the interactions and regulatory functions of RNA.
Crystallographic ‘snapshots’ taken at intervals of femtoseconds to milliseconds after activation show how a light-activated sodium pump carries sodium ions across the cell membrane.
Nomura (NMR) seems to be a good value pick, as it has decent revenue metrics to back up its earnings, and is seeing solid earnings estimate revisions as well.
(Bloomberg) -- Nomura Holdings Inc.’s new chief executive officer is set to unveil his strategy for Japan’s biggest brokerage on Tuesday, as the firm comes under renewed market scrutiny after posting losses caused by the coronavirus pandemic.Kentaro Okuda may redouble his predecessor’s efforts to reduce the firm’s reliance on trading and shift it toward more stable earnings drivers such as advice to companies and wealthy Japanese individuals. The impetus for doing so was made clear during last quarter’s market turmoil, when writedowns on loans and investments led to Nomura’s first loss in five quarters.“The market was particularly volatile in March because of the coronavirus problems, so the losses were probably inevitable,” said Kaori Nishizawa, an analyst at Fitch Ratings in Tokyo. Nevertheless, “Nomura is still quite susceptible to market volatility -- its profit isn’t stable.”Read how Okuda faces a tough initiation at Nomura’s helmOkuda’s strategy is likely to include working more with privately held companies and stepping up advice in areas such as ESG initiatives, according to introductory remarks he made last month. Nomura is hoping the new focus will unlock more deals with unlisted Japanese firms, the Financial Times reported earlier this week. The new CEO may also address how to revive the struggling domestic retail franchise at a time when Japan’s recession is deepening.Below is a series of charts illustrating Okuda’s challenge, as he prepares to give a presentation to investors in Tokyo on Tuesday.Okuda, 56, may face pressure to address Nomura’s appetite for risk after it booked large impairment losses last quarter, including on leveraged loans that it was forced to mark to market. An increase in risk-weighted assets caused Nomura’s capital buffers to drop.“Reducing loan positions can be one option if they want to make themselves more tolerant of market volatility and stabilize profit,” said Toshihiro Matsuo, an analyst at S&P Global Ratings. “But those loans are being extended as part of wholesale business, such as bridge financing for clients seeking mergers, so if they choose that option that could cause their wholesale business to shrink.”Nomura lost money abroad last quarter for the first time in a year, dashing hopes that the firm’s overseas woes have ended. While analysts have lauded a cost-cutting program introduced by then-CEO Koji Nagai last year, Okuda may have to expand on that, according to Bloomberg Intelligence.Read Nisha Gopalan’s column on Nomura’s uncomfortable home truths“We believe further cost reduction is needed to stabilize and boost its earnings, while weak and volatile markets in Europe may hinder Nomura’s profit recovery,” Shin Tamura, a senior analyst at Bloomberg Intelligence, wrote recently.Nomura has troubles at home, too. The coronavirus has tested the company’s dependence on face-to-face services after it was forced to suspend operations at branches during a state of emergency to quell the outbreak.The firm’s retail client base is aging and it faces intensifying competition for a new generation of customers who are flocking to cheaper online rivals that don’t run costly outlets. Nomura has already been cutting branches as part of its one-year-old restructuring program.“The fundamental question is whether it’s fine to leave the retail business model unchanged in the face of Japan’s structural changes posed by the aging and shrinking population,” Nishizawa said. “Where will they make money?”For more articles like this, please visit us at bloomberg.comSubscribe now to stay ahead with the most trusted business news source.©2020 Bloomberg L.P.
Using high-resolution atomic force microscopy of live cells, the authors present an updated view of the cell walls of both Staphylococcus aureus and Bacillus subtilis.
HSBC's new strategy overhaul is expected to include job cuts and reduce the banks' presence in some smaller markets.
Me, myself, bye: regional alterations in glutamate and the experience of ego dissolution with psilocybin
The third largest global economy after the United States and China is further pushed to the brink of a slump by the coronavirus outbreak in China.
Cryo-electron microscopy studies of the influenza haemagglutinin glycoprotein at the low pH of host endosomes reveals structural intermediates, offering a dynamic view of how the protein mediates membrane fusion.
Using high-resolution atomic force microscopy of live cells, the authors present an updated view of the cell walls of both Staphylococcus aureus and Bacillus subtilis.
Following cell division, phase separation of the transmembrane adaptor LEM2 ensures that the ESCRT machinery remodels microtubules and seals the nuclear envelope.
Goldman Sachs (GS) might offer loans to small businesses through Amazon's lending platform.
BlackRock's (BLK) efforts to expand in China will help diversification, and lead to further top-line growth.
JPMorgan (JPM) receives final approval from regulators to set up a majority-owned securities joint venture in China.
LONDON/MILAN (Reuters) - Goldman Sachs
Following cell division, phase separation of the transmembrane adaptor LEM2 ensures that the ESCRT machinery remodels microtubules and seals the nuclear envelope.
LONDON/MILAN (Reuters) - Goldman Sachs, JPMorgan, Citigroup Inc, Credit Suisse and other banks have curbed trips to Italy amid fears that the coronavirus outbreak across the north of the country could quickly spread across Europe, sources said. Lazard, BNP Paribas and Deutsche Bank also rushed to warn staff against all "non-essential travel" to northern Italy, four sources told Reuters, speaking on condition of anonymity as banking policies are confidential.
Cryo-electron microscopy studies of the influenza haemagglutinin glycoprotein at the low pH of host endosomes reveals structural intermediates, offering a dynamic view of how the protein mediates membrane fusion.
Dimethyl sulfate mutational profiling with sequencing, combined with the newly developed DREEM algorithm, reveals that heterogeneity of RNA structure in HIV-1 regulates the use of splice sites and expression of viral genes.
New research demonstrates that an applied magnetic field will interact with the electronic structure of weakly magnetic, or diamagnetic, molecules to induce a magnetic-field effect that, to their knowledge, has never before been documented. With the experimen…