| Dec'19 | Dec'18 | Dec'17 | Dec'16 | Dec'15 | Dec'14 | Dec'13 | Dec'12 | Dec'11 | Dec'10 |
|---|---|---|---|---|---|---|---|---|---|
Revenue | |||||||||
Collaborations and contracts | |||||||||
- | - | - | 229 | 11,712 | 11,738 | 10,425 | 12,105 | 16,311 | - |
Licensing fees, milestone and royalty payments | |||||||||
- | - | - | 1,262 | 11,564 | 3,215 | 5,040 | 2,000 | 500 | - |
Revenue | |||||||||
6,011 | 5,945 | 10,700 | 1,491 | 23,276 | 14,953 | 15,465 | 14,105 | 16,811 | - |
Non-cash royalty revenue | |||||||||
1,656 | 0 | - | - | - | - | - | - | - | - |
Operating expenses | |||||||||
Non-cash royalty revenue | |||||||||
Research and development | |||||||||
57,601 | 57,934 | 62,676 | 61,253 | 51,505 | 38,713 | 21,458 | 18,043 | 20,131 | - |
General and administrative | |||||||||
17,727 | 16,002 | 16,129 | 39,438 | 26,438 | 8,683 | 5,546 | 8,141 | 6,386 | - |
Depreciation | |||||||||
2,028 | 2,181 | 2,027 | 1,092 | 589 | 529 | 613 | 866 | 986 | - |
Gain on disposition of financial instrument | |||||||||
- | - | - | 1,000 | 0 | 0 | - | - | - | - |
Warrant issuance costs (note 5) | |||||||||
- | - | - | - | - | - | - | 47 | 80 | - |
Fair Value, Option, Changes in Fair Value, Gain (Loss) | |||||||||
- | - | -22 | 530 | 3,341 | -10,383 | -3,530 | -3,822 | 579 | - |
Change in fair value of contingent consideration | |||||||||
-173 | -7,298 | 1,359 | 1,568 | 770 | 0 | 0 | - | - | - |
Site consolidation | |||||||||
156 | 4,797 | 0 | - | - | - | - | - | - | - |
Acquisition costs | |||||||||
- | - | - | 0 | 9,656 | 462 | 0 | - | - | - |
Impairment of Intangible Assets (Excluding Goodwill) | |||||||||
43,836 | 14,811 | 40,798 | 253,197 | 39,007 | 0 | 0 | - | - | - |
Impairment of goodwill | |||||||||
22,471 | 0 | - | 138,150 | 0 | 0 | - | - | - | - |
Licensing settlement payment (note 3(c)) | |||||||||
- | - | - | - | - | - | - | 65,000 | - | - |
Legal Fees | |||||||||
6,266 | 0 | - | - | - | - | - | 18,738 | - | - |
Total operating expenses | |||||||||
150,085 | 95,725 | 121,630 | 493,130 | 127,195 | 48,387 | 27,617 | 27,050 | 27,505 | - |
Total operating expenses | |||||||||
-144,074 | -89,780 | -110,930 | -491,639 | -103,919 | -33,434 | -12,152 | -12,945 | -10,693 | - |
Loss from operations | |||||||||
Interest income | |||||||||
2,111 | 3,047 | 1,538 | 1,391 | 674 | 853 | 540 | 138 | 126 | - |
Interest expense | |||||||||
2,108 | 226 | 261 | 0 | 0 | - | - | - | - | - |
Foreign exchange (losses) / gains | |||||||||
41 | -1,003 | 2,301 | 1,120 | 21,771 | 4,127 | 1,079 | 25 | -14 | - |
Other income - Net equity investment gain or loss | |||||||||
-22,522 | 19,322 | - | - | - | - | - | - | - | - |
Gain (Loss) on Investments | |||||||||
- | - | 0 | - | - | - | - | - | - | - |
Net equity investment loss | |||||||||
- | - | 0 | - | - | - | - | - | - | - |
Total other loss | |||||||||
-22,305 | 28,438 | 2,197 | 2,473 | 25,016 | -5,403 | -1,911 | - | - | - |
Loss before income taxes | |||||||||
-166,379 | -61,342 | - | - | - | - | - | - | - | - |
Loss before income taxes | |||||||||
- | - | -108,733 | -489,166 | -78,903 | -38,837 | -14,063 | - | - | - |
Income tax benefit | |||||||||
-12,656 | -4,282 | -24,320 | -105,002 | -16,185 | 0 | 0 | - | - | - |
Net Income (Loss) Attributable to Parent | |||||||||
-153,723 | -57,060 | -84,413 | -384,164 | -62,718 | -38,837 | -14,063 | 29,611 | -10,083 | - |
Items applicable to preferred shares: | |||||||||
Dividend accretion of convertible preferred shares | |||||||||
11,149 | 10,091 | 911 | 0 | 0 | - | - | - | - | - |
Net loss attributable to common shares | |||||||||
-164,872 | -67,151 | -85,324 | -384,164 | -62,718 | - | - | - | - | - |
Net loss attributable to common shareholders, per share | |||||||||
Basic (in USD per share) | |||||||||
- | - | -1.56 | -7.24 | -1.38 | -1.80 | -0.92 | 2.16 | -0.89 | - |
Diluted (in USD per share) | |||||||||
- | - | -1.56 | -7.24 | -1.38 | -1.80 | -0.92 | 2.07 | -0.89 | - |
Basic and dilutive (in USD per share) | |||||||||
-2.89 | -1.21 | - | - | - | - | - | - | - | - |
Net loss per common share | |||||||||
Weighted average number of common shares | |||||||||
Basic (in shares) | |||||||||
- | - | 54,723 | 53,074 | 45,462 | 21,603 | 15,302 | 13,727 | 11,318 | 10,332 |
Weighted Average Number of Shares Outstanding, Diluted | |||||||||
- | - | 54,723 | 53,074 | 45,462 | 21,603 | 15,302 | 14,320 | 11,318 | 10,332 |
Comprehensive income | |||||||||
Currency translation adjustment | |||||||||
-59 | 15 | 0 | 0 | -25,872 | -6,489 | -3,135 | 474 | -53 | - |
Comprehensive loss | |||||||||
-153,782 | -57,045 | -84,413 | -384,164 | -88,590 | -45,326 | -17,198 | 30,085 | -10,136 | - |
Collaboration And Contracts [Member] | |||||||||
Revenue | |||||||||
4,355 | 5,945 | - | - | - | - | - | - | - | - |
Royalty [Member] | |||||||||
Non Cash Royalty Revenue Related To Sale Of Future Royalties | |||||||||
-1,656 | - | - | - | - | - | - | - | - | - |
Common Shares | |||||||||
Preferred Stock Dividends and Other Adjustments | |||||||||
0 | 0 | - | - | - | - | - | - | - | - |
Net loss attributable to common shares | |||||||||
-164,872 | -67,151 | - | - | - | - | - | - | - | - |
Earnings Per Share, Basic and Diluted | |||||||||
-2.89 | -1.21 | - | - | - | - | - | - | - | - |
Weighted Average Number of Shares Outstanding, Basic and Diluted | |||||||||
57,093 | 55,304 | - | - | - | - | - | - | - | - |