| Dec'19 | Dec'18 | Dec'17 | Dec'16 | Dec'15 | Dec'14 | Dec'13 | Dec'12 | Dec'11 | Dec'10 | Dec'09 |
|---|---|---|---|---|---|---|---|---|---|---|
Revenues | ||||||||||
Collaborative revenue | ||||||||||
- | - | - | - | 61 | 120 | - | - | - | - | - |
Total revenues | ||||||||||
339,076 | 223,807 | 124,901 | 17,331 | 61 | 120 | 1,145 | 4,907 | 2,067 | 42,135 | 6,399 |
Operating expenses | ||||||||||
Cost of product sales | ||||||||||
11,344 | 12,377 | 9,077 | 3,075 | - | - | - | - | - | - | - |
License fees and royalties | ||||||||||
8,254 | 5,953 | 3,983 | 1,331 | 2,500 | - | - | - | - | - | - |
Research and development | ||||||||||
240,385 | 187,163 | 149,189 | 99,284 | 73,869 | 60,602 | 26,722 | 18,794 | 17,309 | 20,579 | 41,585 |
Selling, general and administrative | ||||||||||
325,638 | 265,758 | 255,062 | 186,456 | 88,304 | 32,748 | 12,720 | 6,999 | 7,610 | 6,462 | 10,282 |
Total operating expenses | ||||||||||
585,621 | 471,251 | 417,311 | 290,146 | 164,673 | 93,350 | 39,442 | 25,793 | 24,919 | 27,041 | 51,867 |
Loss from operations | ||||||||||
-246,545 | -247,444 | -292,410 | -272,815 | -164,612 | -93,230 | -38,297 | -20,886 | -22,852 | 15,094 | -45,468 |
Interest income, net | ||||||||||
11,165 | 5,348 | 4,126 | 2,763 | 499 | 755 | 349 | 37 | 87 | 45 | 323 |
Other expense | ||||||||||
997 | -1,840 | - | - | - | - | - | - | - | - | - |
Loss before income taxes | ||||||||||
-234,383 | -243,936 | -288,284 | -270,052 | -164,113 | -92,475 | -37,948 | - | - | - | - |
Income tax expense | ||||||||||
876 | 1,256 | 1,119 | 1,341 | 330 | - | - | - | - | - | - |
Net loss | ||||||||||
-235,259 | -245,192 | -289,403 | -271,393 | -164,443 | -92,475 | -37,948 | -20,849 | -22,765 | 15,139 | -45,145 |
Net loss per common share, basic and diluted | ||||||||||
-1.60 | -1.94 | -2.36 | -2.34 | -1.63 | -0.95 | -0.44 | -0.38 | -0.44 | - | - |
Weighted average common shares outstanding, basic and diluted | ||||||||||
147,199 | 126,583 | 122,600 | 115,858 | 100,630 | 97,248 | 85,715 | 55,116 | 52,183 | - | - |
Net income (loss) per common share, basic | ||||||||||
- | - | - | - | - | - | - | - | - | 0.39 | -1.20 |
Net income (loss) per common share, diluted | ||||||||||
- | - | - | - | - | - | - | - | - | 0.39 | -1.20 |
Weighted average common shares outstanding, basic | ||||||||||
- | - | - | - | - | - | - | - | - | 38,593 | 37,476 |
Weighted average common shares outstanding, diluted | ||||||||||
- | - | - | - | - | - | - | - | - | 38,720 | 37,476 |
Product [Member] | ||||||||||
Product sales, net | ||||||||||
- | - | - | 17,327 | - | - | - | - | - | - | - |
Product and Service, Other [Member] | ||||||||||
Product sales, net | ||||||||||
- | - | - | 4 | - | - | - | - | - | - | - |