| Dec'19 | Dec'18 | Dec'17 | Dec'16 | Dec'15 | Dec'14 | Dec'13 | Dec'12 | Dec'11 | Dec'10 |
|---|---|---|---|---|---|---|---|---|---|
Operating expenses: | |||||||||
Option Revenue | |||||||||
- | - | - | - | 2,556 | 1,271 | 1,266 | - | - | - |
Research and development | |||||||||
13,851 | 12,452 | 8,725 | 5,308 | 10,039 | 12,118 | 9,181 | 6,318 | 3,340 | 2,584 |
General and administrative | |||||||||
16,046 | 9,261 | 5,223 | 1,391 | 4,258 | 3,833 | 3,670 | 2,508 | 2,406 | 2,216 |
Total operating expenses | |||||||||
29,897 | 21,713 | 13,948 | 6,699 | - | - | - | - | - | - |
Loss from operations | |||||||||
-29,897 | -21,713 | -13,948 | -6,699 | -12,093 | -15,067 | -11,923 | -9,133 | -5,966 | -4,970 |
Other income, net: | |||||||||
Interest income (expense), net | |||||||||
- | - | - | - | 5 | 13 | - | - | - | - |
Interest income | |||||||||
471 | 412 | 14 | 0 | - | - | 14 | 0 | 0 | 1 |
Loss on extinguishment of debt | |||||||||
- | - | - | - | - | - | -2,518 | - | - | - |
Gain on derivative instruments | |||||||||
- | - | - | - | - | - | - | 552 | - | - |
Interest expense | |||||||||
- | - | - | - | - | - | 2,267 | 350 | 3 | 500 |
Interest and other expense | |||||||||
- | - | -245 | 0 | - | - | - | - | - | - |
Foreign currency transaction (loss) gain | |||||||||
8 | 20 | -16 | 0 | - | - | - | - | - | - |
Total other income, net | |||||||||
479 | 433 | - | - | - | - | - | - | - | - |
Depreciation and amortization | |||||||||
- | - | - | - | 351 | 387 | 335 | 303 | 210 | 168 |
Impairment loss | |||||||||
- | - | - | - | 0 | - | - | - | - | - |
Loss on disposal of asset | |||||||||
- | - | - | - | -1 | 0 | -2 | -3 | -9 | -0 |
Total other income, net | |||||||||
- | - | -246 | 0 | 68 | 2 | 37 | - | - | - |
Net loss | |||||||||
-29,417 | -21,280 | -14,194 | -6,699 | -12,019 | -15,052 | -16,656 | -8,930 | -5,968 | -5,469 |
Net loss per share - basic and diluted | |||||||||
-2.91 | -2.49 | -3.84 | -2.73 | -2.05 | -4.33 | -1.25 | -1.54 | -1.06 | -0.32 |
Weighted average common shares outstanding - basic and diluted | |||||||||
10,092 | 8,555 | 3,694 | 2,450 | 5,854 | 3,477 | 13,332 | 5,785 | 5,633 | - |
Weighted average shares outstanding | |||||||||
- | - | - | - | - | - | - | - | - | 17,071 |