| Dec'18 | Dec'17 | Dec'16 | Dec'15 | Dec'14 | Dec'13 | Dec'12 | Dec'11 | Dec'10 | Dec'09 |
|---|---|---|---|---|---|---|---|---|---|
Cash flows from operating activities | |||||||||
Net loss | |||||||||
-70,272 | -85,236 | -61,706 | -5,030 | -69,008 | -58,947 | -47,127 | -44,206 | -25,481 | -25,932 |
Adjustments to reconcile net loss to net cash used in operating activities: | |||||||||
Depreciation and amortization | |||||||||
1,158 | 1,126 | 955 | 694 | 489 | 399 | 408 | 327 | 615 | 987 |
Non-cash stock-based compensation | |||||||||
9,380 | 10,573 | 11,006 | 10,072 | 7,273 | 5,920 | 3,932 | 2,989 | 2,263 | 1,940 |
Premium on purchases of marketable securities | |||||||||
59 | 1,094 | 565 | 2,486 | 947 | 3,387 | - | - | - | - |
Amortization of (discount) premium on marketable securities | |||||||||
641 | -1,079 | -985 | - | - | - | - | - | - | - |
Noncash interest expense | |||||||||
- | - | - | - | - | - | - | 9 | 52 | 70 |
Loss on disposal of fixed assets | |||||||||
-49 | - | -8 | -2 | 2 | - | -1 | 111 | -6 | - |
Premium on purchases of marketable securities | |||||||||
- | - | - | - | - | - | 755 | 574 | -406 | - |
Amortization of premium on marketable securities | |||||||||
- | - | - | 2,002 | 1,959 | 2,360 | 444 | 478 | 325 | 125 |
Changes in operating assets and liabilities: | |||||||||
Accounts and other receivables | |||||||||
290 | -15,196 | 14,750 | 411 | -385 | - | - | - | - | - |
Accounts and other receivables | |||||||||
- | - | - | - | - | 203 | 174 | -143 | 181 | 65 |
Prepaid expenses and other assets | |||||||||
242 | 313 | 721 | 837 | -575 | 104 | 757 | -739 | 1,348 | -490 |
Accounts payable | |||||||||
-2,940 | -1,577 | 2,693 | -2,285 | 1,827 | 315 | -519 | 2,123 | 395 | -267 |
Accrued expenses | |||||||||
1,911 | 834 | -3,707 | 3,856 | 1,925 | 11 | 502 | 1,947 | -537 | 338 |
Other long-term liabilities | |||||||||
-66 | -66 | 149 | - | - | - | - | - | - | - |
Deferred revenue | |||||||||
- | - | - | - | - | - | -2,489 | - | - | - |
Net cash used in operating activities | |||||||||
- | - | - | 5,577 | -55,524 | -53,636 | -46,534 | - | - | - |
Net cash used in operating activities | |||||||||
-62,012 | -59,478 | -65,653 | - | - | - | - | -36,136 | -24,297 | -22,314 |
Cash flows from investing activities | |||||||||
Purchases of fixed assets | |||||||||
515 | 626 | 2,508 | 704 | 947 | 408 | 656 | 732 | 169 | 42 |
Release of restriction on cash | |||||||||
- | - | - | - | - | - | - | - | - | -53 |
Purchases of marketable securities | |||||||||
223,060 | 345,490 | 499,115 | 692,525 | 79,338 | 168,117 | 79,759 | 79,706 | 39,294 | 7,339 |
Maturities of marketable securities | |||||||||
289,891 | 372,091 | 562,292 | 394,575 | 123,625 | 103,491 | 85,050 | - | - | - |
Maturities of marketable securities | |||||||||
- | - | - | - | - | - | - | 45,774 | 9,550 | 31,396 |
Net cash provided by (used in) investing activities | |||||||||
- | - | - | -298,654 | 43,340 | -65,034 | 4,635 | - | - | - |
Net cash provided by investing activities | |||||||||
66,316 | 25,975 | 60,669 | - | - | - | - | -34,664 | -29,913 | 24,068 |
Cash flows from financing activities | |||||||||
Proceeds from issuance of common stock, net of issuance costs | |||||||||
- | - | - | - | - | - | 41,660 | 60,947 | 72,562 | - |
Proceeds from exercise of stock options | |||||||||
2,053 | 39 | 108 | 3,730 | 4,067 | 555 | 2,378 | 570 | 77 | 6 |
Proceeds from exercise of warrants | |||||||||
- | - | - | - | 5,251 | - | - | - | - | - |
Proceeds from sale of common stock under Employee Stock Purchase Plan | |||||||||
146 | 225 | 214 | 290 | 241 | 185 | 197 | 146 | 99 | 102 |
Payment of deferred financing costs | |||||||||
- | 175 | - | - | - | - | 247 | 18 | - | - |
Borrowings of debt | |||||||||
- | - | 444 | 229 | 440 | - | 609 | 438 | - | - |
Repayments of debt | |||||||||
170 | 351 | 246 | 248 | 313 | 350 | 282 | - | - | - |
Repayments of debt | |||||||||
- | - | - | - | - | - | - | 546 | 2,867 | 3,035 |
Net cash provided by (used in) financing activities | |||||||||
- | - | - | 301,138 | 52,391 | 133,601 | 44,315 | - | - | - |
Payment of deferred financing costs | |||||||||
- | - | - | - | - | - | - | - | - | 175 |
Net cash provided by financing activities | |||||||||
2,029 | -262 | 520 | - | - | - | - | 61,537 | 69,871 | -3,102 |
Net decrease in cash and cash equivalents | |||||||||
6,333 | -33,765 | -4,464 | - | - | - | - | - | - | - |
Net decrease in cash and cash equivalents | |||||||||
- | - | - | 8,061 | 40,207 | 14,931 | 2,416 | -9,263 | 15,661 | -1,348 |
Supplemental disclosure of cash flow information | |||||||||
Cash paid for interest | |||||||||
37 | 52 | 46 | - | - | - | - | - | - | - |
Supplemental disclosure of non-cash activities | |||||||||
Cash paid for interest | |||||||||
- | - | - | 50 | 35 | 46 | 60 | 33 | 207 | 468 |
Cashless exercise of warrants | |||||||||
- | 8,750 | - | 53 | 2,848 | 47 | 14,106 | - | - | - |
Purchases of fixed assets in accounts payable and accrued expenses | |||||||||
49 | 36 | 199 | - | - | - | - | - | - | - |
Cashless exercise of warrants | |||||||||
- | - | - | - | - | - | - | 43 | - | - |
Issuance of common stock for Standby Equity Distribution Agreement commitment fee | |||||||||
- | - | - | - | - | - | - | - | - | 300 |