| Dec'18 | Dec'17 | Dec'16 | Dec'15 | Dec'14 | Dec'13 | Dec'12 | Dec'11 | Dec'10 | Dec'09 |
|---|---|---|---|---|---|---|---|---|---|
Revenue | |||||||||
- | - | 15,000 | 66,122 | - | - | 2,607 | 247 | 2,436 | -294 |
Operating expenses | |||||||||
Research and development | |||||||||
50,118 | 63,607 | 56,843 | 56,553 | 53,515 | 46,736 | 38,999 | 35,441 | 20,529 | 18,419 |
General and administrative | |||||||||
23,896 | 25,969 | 23,022 | 24,676 | 15,911 | 12,741 | 10,901 | 9,153 | 7,205 | 6,553 |
Restructuring charges (Note 4) | |||||||||
1,900 | - | - | - | - | - | - | - | - | 274 |
Total operating expenses | |||||||||
75,914 | 89,576 | 79,865 | 81,229 | 69,426 | 59,477 | 49,900 | 44,594 | 27,734 | 25,246 |
Loss from operations | |||||||||
-75,914 | -89,576 | -64,865 | -15,107 | -69,426 | -59,477 | -47,293 | -44,347 | -25,298 | -25,540 |
Other income (expense) | |||||||||
Interest income | |||||||||
5,678 | 4,390 | 3,227 | 1,188 | 455 | 582 | 234 | - | - | 172 |
Interest income | |||||||||
- | - | - | - | - | - | - | 186 | - | - |
Interest income | |||||||||
- | - | - | - | - | - | - | - | 101 | - |
Interest expense | |||||||||
36 | 50 | 68 | 55 | 37 | 52 | 68 | 45 | 284 | 564 |
Other income | |||||||||
- | - | - | 8,944 | - | - | - | - | - | - |
Net loss | |||||||||
-70,272 | -85,236 | -61,706 | -5,030 | -69,008 | -58,947 | -47,127 | -44,206 | -25,481 | -25,932 |
Basic and diluted net loss per share (Note 5) | |||||||||
-0.51 | -0.62 | -0.45 | -0.04 | -0.70 | -0.63 | -0.64 | -0.69 | -0.57 | -0.98 |
Unrealized income (loss) on marketable securities | |||||||||
190 | -540 | 196 | - | - | - | - | - | - | - |
Unrealized income (loss) on marketable securities | |||||||||
- | - | - | -33 | -18 | -13 | 39 | - | - | - |
Unrealized (loss) gain on marketable securities | |||||||||
- | - | - | - | - | - | - | -22 | 2 | - |
Total other comprehensive income (loss) | |||||||||
190 | -540 | 196 | -33 | -18 | -13 | 39 | -22 | 2 | - |
Total comprehensive loss (Note 9) | |||||||||
-70,082 | -85,776 | -61,510 | -5,063 | -69,026 | -58,960 | -47,088 | -44,228 | -25,479 | - |
Weighted average number of shares used in computing basic and diluted net loss per share | |||||||||
138,418 | 137,180 | 136,667 | 125,592 | 98,367 | 93,983 | 73,965 | 64,248 | 45,079 | - |
Weighted average shares used in computing basic and diluted net loss per share attributable to common stockholders | |||||||||
- | - | - | - | - | - | - | - | - | 26,537 |