| Dec'19 | Dec'18 | Dec'17 | Dec'16 | Dec'15 | Dec'14 | |
|---|---|---|---|---|---|---|
Cash flows from operating activities: | ||||||
Net loss | ||||||
-161,354 | -132,738 | -68,523 | -48,079 | -20,563 | - | |
Net loss | ||||||
- | - | - | - | - | -8,517 | |
Adjustments to reconcile net loss to net cash used in operating activities: | ||||||
Depreciation and amortization | ||||||
6,409 | 1,879 | 402 | 120 | 90 | - | |
Depreciation expense | ||||||
- | - | - | - | - | 12 | |
Stock-based compensation expense | ||||||
16,177 | 20,055 | 14,430 | 6,104 | 891 | 27 | |
Change in fair value of contingent consideration | ||||||
734 | 1,272 | - | - | - | - | |
Goodwill impairment charge | ||||||
18,504 | - | - | - | - | - | |
Intangible asset impairment charge | ||||||
27,638 | - | - | - | - | - | |
Payment of Confluence development milestone | ||||||
- | 717 | - | - | - | - | |
Gain on sale of RHOFADE | ||||||
1,850 | - | - | - | - | - | |
Deferred taxes | ||||||
- | - | -1,837 | - | - | - | |
Write-down of equipment held for sale | ||||||
- | - | - | 216 | 289 | - | |
Non-cash charges related to Vixen acquisition | ||||||
- | - | - | 2,784 | - | - | |
Changes in operating assets and liabilities: | ||||||
Accounts receivable | ||||||
809 | 4,380 | - | - | - | - | |
Inventory | ||||||
-605 | -102 | - | - | - | - | |
Prepaid expenses and other assets | ||||||
-2,628 | 40 | 4,306 | 8 | 1,269 | 152 | |
Accounts payable | ||||||
-3,160 | 6,964 | 4,564 | 1,810 | -359 | 819 | |
Accrued expenses | ||||||
-1,967 | 6,792 | 607 | 2,450 | 552 | 175 | |
Net cash used in operating activities | ||||||
-96,445 | -100,811 | -54,663 | -34,603 | -20,369 | - | |
Cash flows from investing activities: | ||||||
Net cash used in operating activities | ||||||
- | - | - | - | - | -7,636 | |
Purchases of property and equipment | ||||||
1,613 | 1,356 | 1,235 | 232 | 507 | 417 | |
Acquisition of RHOFADE | ||||||
- | 67,122 | - | - | - | - | |
Disposition of RHOFADE | ||||||
34,186 | - | - | - | - | - | |
Acquisition of Confluence, net of cash acquired | ||||||
- | - | 9,647 | - | - | - | |
Purchases of marketable securities | ||||||
137,385 | 161,598 | 197,337 | 148,764 | 82,513 | 5,035 | |
Proceeds from sales and maturities of marketable securities | ||||||
210,491 | 239,443 | 152,527 | 87,093 | 6,069 | 3,673 | |
Net cash provided by (used in) investing activities | ||||||
105,679 | 9,367 | -55,692 | -61,903 | -76,951 | - | |
Cash flows from financing activities: | ||||||
Proceeds from debt financing, net of issuance costs | ||||||
- | 29,910 | - | - | - | - | |
Loan amount borrowed | ||||||
-30,000 | - | - | - | - | - | |
Payment of Confluence development milestone | ||||||
- | 1,783 | - | - | - | - | |
Finance lease payments | ||||||
523 | 648 | 78 | - | - | - | |
Net cash provided by investing activities | ||||||
- | - | - | - | - | -1,779 | |
Proceeds from issuance of convertible preferred stock, net of issuance costs | ||||||
- | - | - | - | 39,864 | 10,584 | |
Proceeds from the issuance of stock | ||||||
207 | 577 | 235 | 121 | - | - | |
Net cash (used in) provided by financing activities | ||||||
-30,316 | 128,261 | 100,386 | 116,826 | 96,414 | - | |
Net increase (decrease) in cash and cash equivalents | ||||||
-21,082 | 36,817 | -9,969 | 20,320 | - | - | |
Net cash provided by financing activities | ||||||
- | - | - | - | - | 10,584 | |
Net increase (decrease) in cash and cash equivalents | ||||||
- | - | - | - | -906 | 1,169 | |
Supplemental disclosure of non-cash investing and financing activities: | ||||||
Additions to property and equipment included in accounts payable | ||||||
124 | 161 | 274 | 11 | 2 | 91 | |
Fair value of stock issued in connection with Confluence development milestone | ||||||
- | 2,215 | - | - | - | - | |
Fair value of stock issued in connection with Confluence acquisition | ||||||
- | 2,131 | 9,675 | - | - | - | |
Property and equipment obtained pursuant to capital lease financing arrangements | ||||||
- | - | - | 2,355 | - | - | |
Offering costs included in accounts payable | ||||||
- | 210 | 20 | 250 | - | - | |
Operating lease asset recorded as a result of new accounting standard | ||||||
2,132 | - | - | - | - | - | |
Accretion of convertible preferred stock to redemption value | ||||||
- | - | - | - | 1,764 | 2,054 | |
Fair value of preferred stock purchased put option on date of issuance | ||||||
- | - | - | - | - | 1,039 | |
At The Market Offering | ||||||
Proceeds from issuance of common stock, net of issuance costs | ||||||
- | - | 19,311 | - | - | - | |
Follow On Public Offering | ||||||
Proceeds from issuance of common stock, net of issuance costs | ||||||
- | 100,205 | 80,918 | 98,158 | - | - | |
Private Placement | ||||||
Proceeds from issuance of common stock, net of issuance costs | ||||||
- | - | - | 18,547 | - | - | |