| Dec'19 | Dec'18 | Dec'17 | Dec'16 | Dec'15 | Dec'14 | Dec'13 | Dec'12 | Dec'11 |
|---|---|---|---|---|---|---|---|---|
Cash flows from operating activities: | ||||||||
Net loss | ||||||||
-53,240 | -47,149 | -51,508 | -43,157 | -24,399 | -33,353 | -23,426 | -33,363 | -20,101 |
Adjustments to reconcile net loss to net cash used in operating activities: | ||||||||
Non-cash royalty revenue related to royalty monetization | ||||||||
312 | 289 | 151 | 7 | 0 | 0 | - | - | - |
Non-cash interest (income) expense on liability related to royalty monetization | ||||||||
-1,337 | 10,341 | 10,721 | 9,382 | 2,428 | 0 | - | - | - |
Depreciation and amortization | ||||||||
1,668 | 575 | 1,744 | 2,052 | 1,984 | 866 | 593 | 605 | 513 |
Non-cash interest expense related to debt financing | ||||||||
712 | 613 | 1,265 | 877 | 897 | - | - | - | - |
Amortization of premium/discount on investments, net | ||||||||
- | - | - | - | - | -216 | -202 | -380 | -195 |
Non-cash interest expense related to debt financing | ||||||||
- | - | - | - | - | 553 | 442 | 647 | 1,619 |
Stock-based compensation | ||||||||
5,057 | 5,168 | 4,294 | 4,479 | 5,010 | 4,440 | 3,479 | 2,150 | 1,833 |
Revaluation of put option and PIPE warrant liabilities | ||||||||
- | - | - | -767 | -2,136 | -7,040 | 14,071 | 1,439 | -1,512 |
Loss on extinguishment of debt | ||||||||
- | - | - | - | - | - | -1,202 | - | - |
Loss on disposal and impairment of property and equipment | ||||||||
- | - | - | - | -573 | 0 | - | - | - |
Inventory impairment charge | ||||||||
951 | - | 369 | - | 0 | - | - | - | - |
Other | ||||||||
773 | 201 | 198 | -17 | -114 | - | - | -43 | - |
Revaluation of put option and PIPE warrant liabilities | ||||||||
- | - | - | -767 | -2,136 | - | - | - | -1,512 |
Changes in operating assets and liabilities: | ||||||||
Accounts receivable | ||||||||
383 | -1,484 | -4,300 | 2,547 | 3,286 | 0 | - | - | - |
Inventories | ||||||||
3,392 | -102 | -920 | 1,688 | 466 | 0 | - | - | - |
Prepaid expenses and other assets | ||||||||
465 | 850 | -175 | -975 | 783 | -137 | -1,132 | -429 | 434 |
Restricted cash | ||||||||
- | - | - | - | -72 | 0 | 45 | - | 0 |
Tax receivable | ||||||||
-352 | - | 703 | - | 0 | - | - | - | - |
Other assets | ||||||||
220 | - | - | - | - | - | - | - | - |
Accounts payable | ||||||||
-19 | 458 | 309 | -437 | -786 | 90 | 106 | 705 | 987 |
Accrued liabilities | ||||||||
1,141 | 922 | -1,301 | 639 | 325 | -126 | -760 | 2,029 | 1,788 |
Operating lease liabilities | ||||||||
-701 | - | - | - | - | - | - | - | - |
Deferred revenue | ||||||||
-219 | -362 | -361 | 989 | - | - | - | - | - |
Deferred revenue | ||||||||
- | - | - | - | 784 | -217 | 2,630 | - | - |
Deferred rent | ||||||||
- | 113 | 360 | -202 | -284 | -22 | -113 | 354 | -175 |
Net cash used in operating activities | ||||||||
- | - | - | - | - | -34,456 | -487 | -24,582 | - |
Net cash used in operating activities | ||||||||
-51,180 | -29,075 | -29,765 | -29,395 | -19,953 | - | - | - | -15,287 |
Cash flows from investing activities: | ||||||||
Purchase of property and equipment | ||||||||
3,470 | 819 | 2,405 | 3,720 | 1,456 | 5,505 | 3,287 | 826 | 2,019 |
Purchase of investments | ||||||||
100,068 | 30,558 | 7,565 | 996 | 7,266 | 17,430 | 28,009 | 27,167 | 39,367 |
Proceeds from sales of investments | ||||||||
- | - | - | - | - | - | - | - | -2,082 |
Proceeds from maturities of investments | ||||||||
66,975 | 20,500 | - | 6,525 | 16,925 | 17,159 | 24,376 | 42,948 | 9,725 |
Net cash (used in) provided by investing activities | ||||||||
- | - | - | - | - | -5,776 | -6,920 | 14,955 | - |
Net cash provided by investing activities | ||||||||
-36,563 | -10,877 | -9,970 | 1,809 | 8,203 | - | - | - | -29,579 |
Cash flows from financing activities: | ||||||||
Proceeds from sale of future royalties | ||||||||
- | - | - | - | 61,184 | 0 | - | - | - |
Proceeds from issuance of common stock in equity offerings, net of offering costs | ||||||||
- | - | - | - | - | - | 47,943 | 53,174 | 34,939 |
Proceeds from issuance of long-term debt | ||||||||
25,000 | - | - | - | - | 10,000 | 14,958 | - | 19,762 |
Payment of costs in connection with refinancing of long-term debt | ||||||||
190 | - | 204 | 205 | 215 | 0 | - | - | - |
Payment of long-term debt | ||||||||
3,470 | 7,718 | 3,514 | - | 4,534 | 0 | 16,345 | 3,655 | 5,297 |
Extinguishment of debt | ||||||||
8,864 | - | - | - | - | - | 437 | - | - |
Net proceeds from issuance of common stock through equity plans | ||||||||
- | - | - | - | - | 1,869 | 1,757 | 246 | 201 |
Net cash provided by financing activities | ||||||||
- | - | - | - | - | 11,869 | 47,876 | 49,765 | - |
Net proceeds from issuance of common stock in connection with equity financings | ||||||||
1,233 | 81,525 | 15,694 | - | 0 | - | - | - | - |
Net proceeds from issuance of common stock through equity plans | ||||||||
743 | 1,218 | 351 | 179 | 3,199 | - | - | - | - |
Net cash provided by (used in) financing activities | ||||||||
14,452 | 75,025 | 12,327 | -26 | 59,634 | - | - | - | 49,605 |
Net increase (decrease) in cash and cash equivalents | ||||||||
-73,291 | 35,073 | -27,408 | -27,612 | 47,884 | -28,363 | 40,469 | 40,138 | 4,739 |
SUPPLEMENTAL DISCLOSURES OF CASH FLOW INFORMATION: | ||||||||
Cash paid for interest | ||||||||
1,712 | 1,667 | 2,043 | 1,893 | 2,115 | - | - | - | - |
Cash paid for interest | ||||||||
- | - | - | - | - | 1,752 | 1,105 | 1,632 | 1,162 |
Income taxes (refunded) paid | ||||||||
-350 | 2 | 2 | -55 | 782 | 0 | - | - | - |
Conversion of convertible promissory notes into common stock | ||||||||
- | - | - | - | - | - | - | - | 8,137 |
Issuance of common stock upon cashless exercise of warrants | ||||||||
- | - | - | - | 2,544 | 546 | 8,428 | - | 536 |
Reclassification of warrant liability and call option liability to equity | ||||||||
- | - | - | - | - | - | - | - | 906 |
Issuance of warrants for common stock | ||||||||
- | - | - | - | - | - | 1,130 | 5,828 | 967 |
Modification of warrants for common stock | ||||||||
- | - | - | 45 | 100 | 0 | - | - | - |
Tenant improvement allowance receivable | ||||||||
- | - | - | - | - | 239 | - | - | - |
Contingent put option liability | ||||||||
- | - | - | - | - | - | 334 | - | 232 |
Purchases of property and equipment in accounts payable | ||||||||
- | 410 | 222 | 532 | 98 | 182 | - | - | - |
Leasehold paid with note payable | ||||||||
899 | - | - | - | - | - | - | - | - |
Transfer of tenant improvement allowance to sublease | ||||||||
242 | - | - | - | - | - | - | - | - |
Establishment of right-of-use asset due to the adoption of ASU 2016-02 | ||||||||
4,730 | - | - | - | - | - | - | - | - |
Purchases of property and equipment in Accrued liabilities | ||||||||
- | - | - | - | 0 | 23 | 725 | - | - |