| Dec'19 | Dec'18 | Dec'17 | Dec'16 | Dec'15 | Dec'14 | Dec'13 |
|---|---|---|---|---|---|---|
Revenue: | ||||||
Total revenue | ||||||
17,258 | 15,087 | 17,239 | 50,681 | - | - | - |
Collaboration and license revenue | ||||||
- | - | - | - | 71,689 | 13,038 | - |
Grant revenue | ||||||
- | - | - | - | 1,290 | 351 | 828 |
Total revenue | ||||||
- | - | - | - | 72,979 | 13,389 | 828 |
Operating expenses: | ||||||
Research and development | ||||||
67,045 | 75,836 | 89,382 | 87,718 | 58,649 | 23,513 | 10,687 |
General and administrative | ||||||
34,795 | 36,035 | 33,751 | 34,277 | 27,805 | 8,994 | 4,677 |
Loss on impairment of intangible assets | ||||||
5,006 | 3,992 | - | - | - | - | - |
Amortization of intangible assets | ||||||
554 | 584 | 559 | 549 | 89 | 0 | 0 |
Total operating expenses | ||||||
107,400 | 116,447 | 123,692 | 122,544 | 86,543 | 32,507 | 15,364 |
Loss from operations | ||||||
-90,142 | -101,360 | -106,453 | -71,863 | -13,564 | -19,118 | -14,536 |
Loss from remeasurement of fair value of warrants | ||||||
- | - | - | - | 26,077 | 566 | 162 |
Interest income | ||||||
5,451 | 5,284 | 3,444 | 2,219 | 494 | - | - |
Gain on extinguishment of convertible promissory notes | ||||||
- | - | - | - | - | 3,553 | - |
Interest income, net | ||||||
- | - | - | - | - | -2,395 | -1,371 |
Other expense, net | ||||||
-93 | -64 | -218 | -40 | -161 | 1,512 | 15 |
Loss before income tax | ||||||
-84,784 | -96,140 | -103,227 | -69,684 | -39,308 | -17,014 | -16,054 |
Income tax benefit | ||||||
-2,412 | -783 | -11,364 | 21,464 | -99 | - | - |
Net loss | ||||||
-82,372 | -95,357 | -91,863 | -91,148 | -39,209 | -17,014 | -16,054 |
Net loss per common share, basic and diluted | ||||||
-1.03 | -1.21 | -1.26 | -1.40 | -0.88 | -53.06 | -55.80 |
Shares used in computing net loss per common share, basic and diluted | ||||||
80,110 | 78,812 | 72,901 | 65,200 | 44,706 | 320 | 287 |
Collaboration and license revenue | ||||||
Total revenue | ||||||
17,258 | 15,087 | 17,109 | 50,593 | - | - | - |
Grant revenue | ||||||
Total revenue | ||||||
- | - | 130 | 88 | - | - | - |