| Dec'19 | Dec'18 | Dec'17 | Dec'16 | Dec'15 | Dec'14 | Dec'13 |
|---|---|---|---|---|---|---|
Cash flows from operating activities: | ||||||
Net loss | ||||||
-64,486 | -72,627 | -56,147 | - | - | - | - |
Net loss | ||||||
- | - | - | -113,747 | -47,453 | -25,404 | -5,276 |
Adjustments to reconcile net loss to net cash used in operating activities: | ||||||
Depreciation and amortization | ||||||
1,573 | 1,750 | 2,096 | 1,603 | 812 | 162 | 26 |
Stock-based compensation expense | ||||||
9,899 | 13,432 | 8,723 | 11,416 | 11,505 | 8,567 | 515 |
Amortization of debt issuance costs | ||||||
- | - | - | - | - | - | 20 |
Change in fair value of embedded derivative liability | ||||||
- | - | - | - | - | - | 18 |
Amortization of premium and discounts on marketable securities, net | ||||||
1,273 | -24 | -593 | - | -780 | - | - |
Accreted interest on BPI | ||||||
22 | 95 | - | - | - | - | - |
Change in fair value of warrant liabilities | ||||||
- | - | - | - | - | 759 | 92 |
Loss on extinguishment of related-party convertible notes | ||||||
- | - | - | - | - | -204 | -1,671 |
Impairment of goodwill and intangible assets | ||||||
- | 5,000 | - | 60,714 | - | - | - |
Non-cash interest expense | ||||||
- | - | - | - | - | 18 | 53 |
Non-cash research and development expense | ||||||
- | - | 60 | 8 | 218 | - | - |
Other | ||||||
-36 | 17 | -10 | - | -21 | - | - |
Non-cash collaboration acquisition costs associated with sale of Series A convertible preferred stock | ||||||
- | - | - | - | - | - | 812 |
Changes in operating assets and liabilities: | ||||||
Accounts receivable, net | ||||||
- | - | -886 | 437 | 6 | -8 | 7 |
Prepaid expenses and other current assets | ||||||
5,954 | 793 | 491 | -71 | 531 | 624 | 293 |
Deposit and other long-term assets | ||||||
- | 16 | - | - | 3 | -7 | - |
Operating lease right-of-use assets | ||||||
2,168 | - | - | - | - | - | - |
Deposit | ||||||
- | - | - | - | - | - | -144 |
Accounts payable | ||||||
-650 | -67 | 333 | -111 | -312 | -6 | 286 |
Accrued expenses and other current liabilities | ||||||
1,909 | 215 | 487 | -190 | 724 | 2,904 | 80 |
Restructuring liabilities | ||||||
- | - | -25 | -988 | 1,013 | - | - |
Deferred revenue | ||||||
- | -953 | -1,849 | - | - | - | - |
Deferred revenue | ||||||
- | - | - | 3,360 | -2,313 | 7,459 | - |
Deferred rent | ||||||
- | -1,243 | 97 | 65 | -207 | -298 | -8 |
Lease liability | ||||||
7,586 | - | - | - | - | - | - |
Deferred tax liability | ||||||
- | 1,250 | - | - | - | - | - |
Net cash used in operating activities | ||||||
-49,170 | -53,964 | -45,421 | - | - | - | - |
Cash flows from investing activities: | ||||||
Purchases of marketable securities | ||||||
197,343 | 78,726 | - | - | - | - | - |
Net cash used in operating activities | ||||||
- | - | - | -38,366 | -35,338 | -5,648 | -2,175 |
Purchases of marketable securities | ||||||
- | - | 209,787 | - | 88,427 | - | - |
Sales of marketable securities | ||||||
- | - | 1,003 | - | - | - | - |
Maturities of marketable securities | ||||||
148,517 | 148,979 | 87,596 | 37,738 | 49,850 | - | - |
Purchases of property and equipment | ||||||
19,247 | 809 | 1,016 | 2,412 | 2,992 | 943 | 91 |
Net cash provided by (used in) provided by investing activities | ||||||
-68,073 | 69,444 | -122,204 | - | - | - | - |
Cash flows from financing activities: | ||||||
Cash acquired in business acquisition | ||||||
- | - | - | 3,449 | - | - | - |
Net cash provided by (used in) investing activities | ||||||
- | - | - | 38,775 | -41,569 | -943 | -91 |
Proceeds from public offering of common stock, net | ||||||
- | - | - | - | - | 106,453 | - |
Proceeds from offering of common stock, net of issuance costs | ||||||
25,755 | 70,187 | 16,519 | - | 138,954 | - | - |
Proceeds from issuance of common stock through private placement | ||||||
134 | - | - | - | - | - | - |
Proceeds from issuance of related-party convertible notes | ||||||
- | - | - | - | - | 2,000 | 1,500 |
Repurchase of Series A convertible preferred stock | ||||||
- | - | - | - | - | 4,000 | - |
Proceeds from exercises of warrants | ||||||
- | - | - | - | - | 606 | - |
Proceeds from issuance of common stock pursuant to option exercises | ||||||
3,442 | 688 | 367 | 763 | 188 | 18 | - |
Taxes paid related to net share settlement of restricted stock units | ||||||
1,470 | 1,191 | 313 | 493 | 427 | - | - |
Proceeds from employee stock purchase plan | ||||||
442 | 340 | 175 | 186 | 145 | - | - |
Repayment of BPI loan | ||||||
112 | 175 | - | - | - | - | - |
Proceeds from a financing arrangement | ||||||
- | 100 | - | 100 | - | - | - |
Net cash provided by financing activities | ||||||
28,191 | 69,949 | 16,748 | - | - | - | - |
Effect of foreign currency exchange rate on cash and cash equivalents | ||||||
- | - | -774 | - | - | - | - |
Net increase (decrease) in cash and cash equivalents and restricted cash | ||||||
-89,052 | 85,429 | -151,651 | - | - | - | - |
Net cash provided by financing activities | ||||||
- | - | - | 556 | 138,860 | 165,442 | 2,480 |
Effect of foreign currency exchange rate on cash and cash equivalents | ||||||
- | - | - | -143 | -9 | -11 | -7 |
Net increase (decrease) in cash and cash equivalents | ||||||
- | - | - | 822 | 61,944 | 158,840 | 207 |
Supplemental schedule of noncash investing information | ||||||
Issuance of common stock and exchange of stock options for business acquisition | ||||||
- | - | - | 64,845 | - | - | - |
Fixed assets in accounts payable and current liabilities | ||||||
5,242 | 1,616 | 115 | 180 | 178 | - | - |
Conversion of related-party convertible notes payable to convertible preferred stock | ||||||
- | - | - | - | - | 2,000 | 2,059 |
Warrants issued in connection with issuance of Series B convertible preferred stock | ||||||
- | - | - | - | - | 266 | - |
Warrants issued in connection with financing and license agreements | ||||||
- | - | - | - | - | 42 | - |
Fixed assets in accounts payable and current liabilities | ||||||
- | - | - | - | - | 235 | - |
Deferred stock issuance costs | ||||||
- | - | - | - | - | 379 | 50 |