| Dec'19 | Dec'18 | Dec'17 | Dec'16 | Dec'15 | Dec'14 | Dec'13 | Dec'12 |
|---|---|---|---|---|---|---|---|
Collaboration and license revenue | |||||||
250 | 1,612 | 1,849 | - | - | - | - | - |
Collaboration and license revenue | |||||||
- | - | - | 1,455 | 2,319 | 572 | - | - |
Government grant revenue | |||||||
- | - | - | - | - | - | 480 | 30 |
Total revenue | |||||||
- | - | - | - | - | - | 480 | 30 |
Operating expenses: | |||||||
Research and development | |||||||
40,419 | 50,133 | 39,839 | 31,670 | 25,462 | 16,976 | 2,151 | 1,310 |
General and administrative | |||||||
28,376 | 24,560 | 20,857 | 24,355 | 22,107 | 7,998 | 1,783 | 536 |
Impairment of goodwill and intangible assets | |||||||
- | 5,000 | - | 60,714 | - | - | - | - |
Restructuring charges | |||||||
- | - | - | - | 2,573 | - | - | - |
Total operating expenses | |||||||
68,795 | 79,693 | 60,696 | 116,739 | 50,142 | 24,974 | 3,934 | 1,846 |
Operating loss | |||||||
-68,545 | -78,081 | -58,847 | -115,284 | -47,823 | -24,402 | -3,454 | -1,816 |
Other income: | |||||||
Interest expense | |||||||
- | - | - | - | - | 18 | 73 | 8 |
Other income, net | |||||||
- | - | 2,700 | 762 | 370 | -21 | -4 | -6 |
Change in fair value of embedded derivative | |||||||
- | - | - | - | - | - | 18 | 6 |
Change in fair value of warrant liabilities | |||||||
- | - | - | - | - | 759 | 92 | -13 |
Loss on extinguishment of related-party convertible notes | |||||||
- | - | - | - | - | -204 | -1,671 | - |
Other income, net | |||||||
4,059 | 4,204 | - | 762 | 370 | -1,002 | -1,822 | 5 |
Net loss before income taxes | |||||||
-64,486 | -73,877 | -56,147 | -114,522 | -47,453 | -25,404 | - | - |
Income tax benefit | |||||||
0 | -1,250 | 0 | -775 | 0 | 0 | - | - |
Net loss | |||||||
-64,486 | -72,627 | -56,147 | - | - | -25,404 | -5,276 | -1,811 |
Deemed dividend | |||||||
- | - | - | - | - | 3,230 | - | - |
Net loss attributable to common stockholders | |||||||
- | - | - | -113,747 | -47,453 | -28,634 | -5,276 | -1,811 |
Other comprehensive income: | |||||||
Net unrealized gain on marketable securities | |||||||
33 | 168 | -182 | 6 | -6 | - | - | - |
Foreign currency translation adjustment | |||||||
41 | -4 | -774 | -2 | -15 | -17 | 19 | 8 |
Comprehensive loss | |||||||
-64,412 | -72,463 | -57,103 | -113,743 | -47,474 | -25,421 | -5,257 | -1,803 |
Net loss per share - basic and diluted | |||||||
-1.01 | -1.18 | -1.29 | -3.14 | -1.86 | -2.46 | -1.44 | -0.50 |
Weighted-average common shares outstanding-basic and diluted | |||||||
64,102 | 61,375 | 43,661 | 36,246 | 25,479 | 11,651 | 3,673 | 3,643 |