| Dec'19 | Dec'18 | Dec'17 | Dec'16 | Dec'15 | Dec'14 | Dec'13 | Dec'12 | Dec'11 |
|---|---|---|---|---|---|---|---|---|
Total revenues, net | ||||||||
69,888 | 24,181 | 0 | 0 | - | - | - | - | - |
Costs and expenses: | ||||||||
Cost of goods sold | ||||||||
4,833 | 641 | 0 | 0 | - | - | - | - | - |
Costs and expenses: | ||||||||
Selling, general and administrative | ||||||||
138,402 | 120,614 | 56,905 | 34,706 | 30,635 | 20,103 | 10,287 | 5,020 | 3,521 |
Pre-approval commercial manufacturing | ||||||||
22,767 | 26,545 | 16,710 | 9,772 | - | - | - | - | - |
Research and development | ||||||||
91,378 | 86,123 | 72,078 | 52,394 | 44,451 | 29,869 | 11,883 | 9,273 | 10,695 |
Total costs and expenses | ||||||||
257,380 | 233,923 | 145,693 | 96,872 | 75,086 | - | - | - | - |
Loss from operations | ||||||||
-187,492 | -209,742 | -145,693 | -96,872 | -75,086 | -49,972 | -22,170 | -14,293 | -14,216 |
Other (expense) income, net | ||||||||
-12,179 | -22,824 | -1,170 | -1,994 | 862 | 1,839 | -8,978 | -685 | 1,249 |
Loss before income taxes | ||||||||
-199,671 | -232,566 | -146,863 | -98,866 | -74,224 | -48,133 | -31,148 | - | - |
Income tax (benefit) expense | ||||||||
-90 | 3 | -1,758 | 193 | 139 | 0 | 0 | - | - |
Net loss | ||||||||
-199,581 | -232,569 | -145,105 | -99,059 | -74,363 | -48,133 | -31,148 | -14,978 | -12,967 |
Net loss attributable to common stockholdersbasic and diluted | ||||||||
- | - | - | - | - | -48,133 | -31,598 | -15,643 | -13,419 |
Net loss per common share—basic and diluted (in dollars per share) | ||||||||
-4.39 | -5.58 | -4.11 | -3.40 | -2.88 | -2.00 | -6.38 | -16.39 | -14.50 |
Weighted average number of common shares outstanding—basic and diluted (in shares) | ||||||||
45,427 | 41,663 | 35,324 | 29,135 | 25,781 | 24,086 | 4,955 | 954 | 925 |
Net loss | ||||||||
-199,581 | -232,569 | -145,105 | -99,059 | -74,363 | -48,133 | -31,148 | -14,978 | -12,967 |
Unrealized (loss) gain on available-for-sale investments | ||||||||
-92 | 28 | 40 | 111 | -72 | -107 | 0 | 0 | - |
Comprehensive loss | ||||||||
-199,673 | -232,541 | -145,065 | -98,948 | -74,435 | -48,240 | -31,148 | -14,978 | -12,967 |
Product revenues, net | ||||||||
Total revenues, net | ||||||||
69,888 | 24,181 | 0 | 0 | - | - | - | - | - |