| Mar'20 | Dec'19 | Sep'19 | Jun'19 | Mar'19 | Dec'18 | Sep'18 | Jun'18 | Mar'18 | Dec'17 | Sep'17 | Jun'17 | Mar'17 | Dec'16 | Sep'16 | Jun'16 | Mar'16 | Dec'15 | Sep'15 | Jun'15 | Mar'15 | Dec'14 | Sep'14 | Jun'14 | Mar'14 | Dec'13 | Sep'13 | Jun'13 | Mar'13 | Sep'12 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Total revenues, net | |||||||||||||||||||||||||||||
20,341 | 24,657 | 18,544 | 15,835 | 10,852 | 14,456 | 7,302 | 2,423 | 0 | - | 0 | 0 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - |
Costs and expenses: | |||||||||||||||||||||||||||||
Cost of goods sold | |||||||||||||||||||||||||||||
6,092 | 1,684 | 2,063 | 705 | 381 | 377 | 205 | 59 | 0 | - | 0 | 0 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - |
Costs and expenses: | |||||||||||||||||||||||||||||
Selling, general and administrative | |||||||||||||||||||||||||||||
36,902 | 35,467 | 32,171 | 34,482 | 36,282 | 31,887 | 32,685 | 33,112 | 22,930 | 5,503 | 19,774 | 17,153 | 14,475 | 4,892 | 10,627 | 9,386 | 9,801 | 7,648 | 7,462 | 7,502 | 8,023 | 6,380 | 4,944 | 5,167 | 3,612 | 3,594 | 3,287 | 1,940 | 1,466 | 1,416 |
Pre-approval commercial manufacturing | |||||||||||||||||||||||||||||
2,114 | - | - | - | 4,457 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - |
Pre-approval commercial manufacturing | |||||||||||||||||||||||||||||
- | - | 5,841 | 5,819 | - | 7,625 | 7,248 | 6,779 | 4,893 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - |
Research and development | |||||||||||||||||||||||||||||
19,173 | 30,794 | 21,796 | 20,904 | 17,884 | 26,492 | 28,502 | 18,157 | 12,972 | 38,101 | 12,408 | 10,615 | 10,954 | 14,093 | 12,688 | 13,304 | 12,309 | 12,302 | 9,904 | 10,627 | 11,618 | 9,593 | 8,230 | 6,676 | 5,370 | 3,156 | 2,399 | 3,173 | 3,155 | 1,373 |
Total costs and expenses | |||||||||||||||||||||||||||||
64,281 | 74,595 | 61,871 | 61,910 | 59,004 | 66,381 | 68,640 | 58,107 | 40,795 | 60,314 | 32,182 | 27,768 | 25,429 | - | 23,315 | 22,690 | - | - | - | - | - | - | - | - | - | - | - | - | - | - |
Loss from operations | |||||||||||||||||||||||||||||
-43,940 | -49,938 | -43,327 | -46,075 | -48,152 | -51,925 | -61,338 | -55,684 | -40,795 | -60,314 | -32,182 | -27,768 | -25,429 | -28,757 | -23,315 | -22,690 | -22,110 | -19,950 | -17,366 | -18,129 | -19,641 | -15,973 | -13,174 | -11,843 | -8,982 | -6,750 | -5,686 | -5,113 | -4,621 | -2,789 |
Other (expense) income, net | |||||||||||||||||||||||||||||
-5,222 | -5,126 | -6,075 | -1,089 | 111 | 467 | -24,050 | 663 | 96 | -99 | -141 | -618 | -312 | -504 | -460 | -482 | -548 | -512 | -523 | -505 | 2,402 | -528 | 27 | 29 | 2,311 | -3,532 | -5,062 | -1,215 | 831 | -803 |
Loss before income taxes | |||||||||||||||||||||||||||||
-49,162 | -55,064 | -49,402 | -47,164 | -48,041 | -51,458 | -85,388 | -55,021 | -40,699 | -60,413 | -32,323 | -28,386 | -25,741 | -29,261 | -23,775 | -23,172 | -22,658 | -20,462 | -17,889 | -18,634 | -17,239 | - | -13,147 | -11,814 | - | - | - | - | - | - |
Income tax (benefit) expense | |||||||||||||||||||||||||||||
-33 | 0 | 0 | 0 | -90 | 0 | 0 | 3 | 0 | -1,900 | 49 | 47 | 46 | 61 | 39 | 47 | 46 | -85 | 72 | 152 | 0 | - | 0 | 0 | - | - | - | - | - | - |
Net loss | |||||||||||||||||||||||||||||
-49,129 | -55,064 | -49,402 | -47,164 | -47,951 | -51,458 | -85,388 | -55,024 | -40,699 | -58,513 | -32,372 | -28,433 | -25,787 | -29,322 | -23,814 | -23,219 | -22,704 | -20,377 | -17,961 | -18,786 | -17,239 | -16,501 | -13,147 | -11,814 | -6,671 | -10,282 | -10,748 | -6,328 | -3,790 | -3,592 |
Net loss attributable to common stockholdersbasic and diluted | |||||||||||||||||||||||||||||
- | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | -22,704 | - | -17,961 | -18,786 | -17,239 | -16,501 | -13,147 | -11,814 | -6,671 | -10,319 | -10,887 | -6,465 | -3,927 | -3,730 |
Net loss per common share—basic and diluted (in dollars per share) | |||||||||||||||||||||||||||||
-1.07 | -1.20 | -1.09 | -1.04 | -1.06 | -1.17 | -1.96 | -1.40 | -1.05 | -1.64 | -0.89 | -0.82 | -0.76 | -0.87 | -0.81 | -0.87 | -0.85 | -0.76 | -0.69 | -0.73 | -0.70 | -0.69 | -0.54 | -0.49 | -0.28 | 15.09 | -10.81 | -6.59 | -4.07 | -3.87 |
Weighted average number of common shares outstanding—basic and diluted (in shares) | |||||||||||||||||||||||||||||
45,792 | 45,592 | 45,448 | 45,397 | 45,270 | 45,194 | 43,657 | 39,204 | 38,598 | 36,526 | 36,210 | 34,783 | 33,777 | 33,665 | 29,380 | 26,773 | 26,723 | 26,618 | 26,061 | 25,841 | 24,602 | 24,410 | 24,325 | 23,893 | 23,717 | 16,869 | 1,006 | 981 | 965 | 964 |
Net loss | |||||||||||||||||||||||||||||
-49,129 | -55,064 | -49,402 | -47,164 | -47,951 | -51,458 | -85,388 | -55,024 | -40,699 | -58,513 | -32,372 | -28,433 | -25,787 | -29,322 | -23,814 | -23,219 | -22,704 | -20,377 | -17,961 | -18,786 | -17,239 | -16,501 | -13,147 | -11,814 | -6,671 | -10,282 | -10,748 | -6,328 | -3,790 | -3,592 |
Unrealized (loss) gain on available-for-sale investments | |||||||||||||||||||||||||||||
-28 | 66 | -158 | 0 | 0 | 1 | 8 | 148 | -129 | 70 | -17 | 24 | -37 | -55 | -3 | 58 | 111 | -147 | 9 | 17 | 49 | -98 | 4 | 8 | -21 | - | - | - | - | - |
Comprehensive loss | |||||||||||||||||||||||||||||
-49,157 | -54,998 | -49,560 | -47,164 | -47,951 | -51,457 | -85,380 | -54,876 | -40,828 | -58,443 | -32,389 | -28,409 | -25,824 | -29,377 | -23,817 | -23,161 | -22,593 | -20,524 | -17,952 | -18,769 | -17,190 | -16,599 | -13,143 | -11,806 | -6,692 | -10,282 | -10,748 | -6,328 | -3,790 | -3,592 |
Product revenues, net | |||||||||||||||||||||||||||||
Total revenues, net | |||||||||||||||||||||||||||||
20,341 | 24,657 | 18,544 | 15,835 | 10,852 | 14,456 | 7,302 | 2,423 | 0 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - |