| Mar'20 | Dec'19 | Sep'19 | Jun'19 | Mar'19 | Dec'18 | Sep'18 | Jun'18 | Mar'18 | Dec'17 | Sep'17 | Jun'17 | Mar'17 | Dec'16 | Sep'16 | Jun'16 | Mar'16 | Dec'15 | Sep'15 | Jun'15 | Mar'15 | Dec'14 | Sep'14 | Jun'14 | Mar'14 | Dec'13 | Sep'13 | Jun'13 | Mar'13 | Sep'12 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Total revenues, net | |||||||||||||||||||||||||||||
79,377 | 69,888 | 59,687 | 48,445 | 35,033 | 24,181 | 9,725 | 2,423 | 0 | - | 0 | 0 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - |
Costs and expenses: | |||||||||||||||||||||||||||||
Cost of goods sold | |||||||||||||||||||||||||||||
10,544 | 4,833 | 3,526 | 1,668 | 1,022 | 641 | 264 | 59 | 0 | - | 0 | 0 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - |
Costs and expenses: | |||||||||||||||||||||||||||||
Selling, general and administrative | |||||||||||||||||||||||||||||
139,022 | 138,402 | 134,822 | 135,336 | 133,966 | 120,614 | 94,230 | 81,319 | 65,360 | 56,905 | 56,294 | 47,147 | 39,380 | 34,706 | 37,462 | 34,297 | 32,413 | 30,635 | 29,367 | 26,849 | 24,514 | 20,103 | 17,317 | 15,660 | 12,433 | 10,287 | 8,109 | 0 | 0 | 0 |
Pre-approval commercial manufacturing | |||||||||||||||||||||||||||||
0 | - | - | - | 0 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - |
Pre-approval commercial manufacturing | |||||||||||||||||||||||||||||
- | - | 23,742 | 25,149 | - | 26,545 | 0 | 0 | 0 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - |
Research and development | |||||||||||||||||||||||||||||
92,667 | 91,378 | 87,076 | 93,782 | 91,035 | 86,123 | 97,732 | 81,638 | 74,096 | 72,078 | 48,070 | 48,350 | 51,039 | 52,394 | 50,603 | 47,819 | 45,142 | 44,451 | 41,742 | 40,068 | 36,117 | 29,869 | 23,432 | 17,601 | 14,098 | 11,883 | 10,100 | 0 | 0 | 0 |
Total costs and expenses | |||||||||||||||||||||||||||||
262,657 | 257,380 | 249,166 | 255,935 | 252,132 | 233,923 | 227,856 | 191,398 | 161,059 | 145,693 | 108,694 | 99,202 | 0 | - | 0 | 0 | - | - | - | - | - | - | - | - | - | - | - | - | - | - |
Loss from operations | |||||||||||||||||||||||||||||
-183,280 | -187,492 | -189,479 | -207,490 | -217,099 | -209,742 | -218,131 | -188,975 | -161,059 | -145,693 | -114,136 | -105,269 | -100,191 | -96,872 | -88,065 | -82,116 | -77,555 | -75,086 | -71,109 | -66,917 | -60,631 | -49,972 | -40,749 | -33,261 | -26,531 | -22,170 | -18,209 | 0 | 0 | 0 |
Other (expense) income, net | |||||||||||||||||||||||||||||
-17,512 | -12,179 | -6,586 | -24,561 | -22,809 | -22,824 | -23,390 | 519 | -762 | -1,170 | -1,575 | -1,894 | -1,758 | -1,994 | -2,002 | -2,065 | -2,088 | 862 | 846 | 1,396 | 1,930 | 1,839 | -1,165 | -6,254 | -7,498 | -8,978 | -6,249 | 0 | 0 | 0 |
Loss before income taxes | |||||||||||||||||||||||||||||
-200,792 | -199,671 | -196,065 | -232,051 | -239,908 | -232,566 | -241,521 | -188,456 | -161,821 | -146,863 | -115,711 | -107,163 | -101,949 | -98,866 | -90,067 | -84,181 | -79,643 | -74,224 | -66,909 | -60,834 | 0 | - | 0 | 0 | - | - | - | - | - | - |
Income tax (benefit) expense | |||||||||||||||||||||||||||||
-33 | -90 | -90 | -90 | -87 | 3 | -1,897 | -1,848 | -1,804 | -1,758 | 203 | 193 | 193 | 193 | 47 | 80 | 185 | 139 | 224 | 152 | 0 | - | 0 | 0 | - | - | - | - | - | - |
Net loss | |||||||||||||||||||||||||||||
-200,759 | -199,581 | -195,975 | -231,961 | -239,821 | -232,569 | -239,624 | -186,608 | -160,017 | -145,105 | -115,914 | -107,356 | -102,142 | -99,059 | -90,114 | -84,261 | -79,828 | -74,363 | -70,487 | -65,673 | -58,701 | -48,133 | -41,914 | -39,515 | -34,029 | -31,148 | -24,458 | 0 | 0 | 0 |
Net loss attributable to common stockholdersbasic and diluted | |||||||||||||||||||||||||||||
- | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | -79,828 | - | -70,487 | -65,673 | -58,701 | -48,133 | -41,951 | -39,691 | -34,342 | -31,598 | -25,009 | 0 | 0 | 0 |
Net loss per common share—basic and diluted (in dollars per share) | |||||||||||||||||||||||||||||
-1.07 | -1.20 | -1.09 | -1.04 | -1.06 | -1.17 | -1.96 | -1.40 | -1.05 | -1.64 | -0.89 | -0.82 | -0.76 | -0.87 | -0.81 | -0.87 | -0.85 | -0.76 | -0.69 | -0.73 | -0.70 | -0.69 | -0.54 | -0.49 | -0.28 | 15.09 | -10.81 | -6.59 | -4.07 | -3.87 |
Weighted average number of common shares outstanding—basic and diluted (in shares) | |||||||||||||||||||||||||||||
45,792 | 45,592 | 45,448 | 45,397 | 45,270 | 45,194 | 43,657 | 39,204 | 38,598 | 36,526 | 36,210 | 34,783 | 33,777 | 33,665 | 29,380 | 26,773 | 26,723 | 26,618 | 26,061 | 25,841 | 24,602 | 24,410 | 24,325 | 23,893 | 23,717 | 16,869 | 1,006 | 981 | 965 | 964 |
Net loss | |||||||||||||||||||||||||||||
-200,759 | -199,581 | -195,975 | -231,961 | -239,821 | -232,569 | -239,624 | -186,608 | -160,017 | -145,105 | -115,914 | -107,356 | -102,142 | -99,059 | -90,114 | -84,261 | -79,828 | -74,363 | -70,487 | -65,673 | -58,701 | -48,133 | -41,914 | -39,515 | -34,029 | -31,148 | -24,458 | 0 | 0 | 0 |
Unrealized (loss) gain on available-for-sale investments | |||||||||||||||||||||||||||||
-120 | -92 | -157 | 9 | 157 | 28 | 97 | 72 | -52 | 40 | -85 | -71 | -37 | 111 | 19 | 31 | -10 | -72 | -23 | -28 | -37 | -107 | 0 | 0 | 0 | - | - | - | - | - |
Comprehensive loss | |||||||||||||||||||||||||||||
-200,879 | -199,673 | -196,132 | -231,952 | -239,664 | -232,541 | -239,527 | -186,536 | -160,069 | -145,065 | -115,999 | -107,427 | -102,179 | -98,948 | -90,095 | -84,230 | -79,838 | -74,435 | -70,510 | -65,701 | -58,738 | -48,240 | -41,923 | -39,528 | -34,050 | -31,148 | -24,458 | 0 | 0 | 0 |
Product revenues, net | |||||||||||||||||||||||||||||
Total revenues, net | |||||||||||||||||||||||||||||
79,377 | 69,888 | 59,687 | 48,445 | 35,033 | 24,181 | 0 | 0 | 0 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - |