| Dec'19 | Dec'18 | Dec'17 | Dec'16 | Dec'15 | Dec'14 | Dec'13 | Dec'12 | Dec'11 |
|---|---|---|---|---|---|---|---|---|
Revenues: | ||||||||
Grant revenue | ||||||||
- | - | - | - | - | - | - | 34 | 34 |
Total revenue | ||||||||
117,912 | 94,387 | 43,011 | 69,892 | 59,119 | - | - | 25,106 | 21,837 |
Cost and expenses: | ||||||||
Cost of sales | ||||||||
1,317 | 1,397 | 0 | 0 | - | - | - | - | - |
Research and development | ||||||||
410,894 | 341,324 | 292,681 | 220,163 | 141,827 | 100,371 | 54,502 | 41,037 | 31,253 |
Selling, general and administrative | ||||||||
132,034 | 114,145 | 71,124 | 50,714 | 35,992 | 19,120 | 9,929 | 7,064 | 7,215 |
Total cost and expenses | ||||||||
544,245 | 456,866 | 363,805 | 270,877 | 177,819 | 119,491 | 64,431 | 48,101 | 38,468 |
Loss from operations | ||||||||
-426,333 | -362,479 | -320,794 | -200,985 | -118,700 | -54,133 | -38,883 | -22,995 | -16,631 |
Interest income, net | ||||||||
14,861 | 16,451 | 6,124 | 2,514 | 968 | 203 | 55 | 69 | 132 |
Loss before income taxes | ||||||||
- | - | - | - | - | -53,930 | -38,828 | -22,926 | -16,499 |
Benefit from income taxes | ||||||||
- | - | - | - | - | -426 | 579 | -2,824 | 7,207 |
Net loss | ||||||||
-411,472 | -346,028 | -314,670 | -198,471 | -117,732 | -53,504 | -39,407 | -20,102 | -23,706 |
Cumulative preferred stock dividends | ||||||||
- | - | - | - | - | - | 4,162 | 7,190 | 3,100 |
Net loss applicable to common stockholders | ||||||||
- | - | - | - | - | - | -43,569 | -27,292 | -26,806 |
Net loss per share – basic and diluted (in usd per share) | ||||||||
-6.86 | -6.03 | -6.75 | -5.07 | -3.15 | -1.59 | -2.83 | -8.02 | -8.90 |
Weighted-average number of common shares used in computing net loss per share – basic and diluted (in usd per share) | ||||||||
59,994 | 57,418 | 46,587 | 39,126 | 37,429 | 33,667 | 15,415 | 3,401 | 3,013 |
Product revenue, net | ||||||||
Total revenue | ||||||||
59,851 | 13,841 | 0 | 0 | - | - | - | - | - |
Collaboration revenue – related party | ||||||||
Total revenue | ||||||||
39,257 | 60,661 | 41,074 | 69,892 | 59,119 | 65,358 | 25,548 | 25,072 | 21,803 |
Collaboration revenue – other | ||||||||
Total revenue | ||||||||
8,262 | 12,670 | 0 | 0 | - | - | - | - | - |
Royalty revenue – related party | ||||||||
Total revenue | ||||||||
10,542 | 7,215 | 1,937 | 0 | 0 | - | - | - | - |