| Dec'19 | Dec'18 | Dec'17 | Dec'16 | Dec'15 | ||
|---|---|---|---|---|---|---|
CASH FLOWS FROM OPERATING ACTIVITIES | ||||||
Net loss | ||||||
-78,254 | -44,348 | -27,236 | -21,698 | - | ||
Net loss | ||||||
- | - | - | - | -11,295 | ||
Adjustments to reconcile net loss to net cash used in operating activities: | ||||||
Depreciation and amortization | ||||||
418 | 293 | 249 | 132 | 89 | ||
Purchase net discount on marketable securities | ||||||
-504 | -907 | -9 | 146 | 5 | ||
Net accretion of discount on marketable securities | ||||||
818 | 593 | -75 | - | - | ||
Net (accretion of discount) amortization of premium on marketable securities | ||||||
- | - | - | -101 | - | ||
Amortization of premium on marketable securities | ||||||
- | - | - | - | 2 | ||
Stock-based compensation | ||||||
4,876 | 4,280 | 2,492 | 1,221 | 767 | ||
Research and development services settled with stock | ||||||
- | 107 | 15 | 110 | 812 | ||
Non-cash operating lease expense | ||||||
483 | - | - | - | - | ||
Other, net | ||||||
5 | 40 | 21 | 10 | 19 | ||
Changes in operating assets and liabilities: | ||||||
Accounts receivable - grant | ||||||
- | -3,078 | 1,863 | -482 | 1,697 | ||
Prepaid expenses and other assets | ||||||
346 | 261 | 114 | 924 | 586 | ||
Accounts payable | ||||||
2,583 | 239 | 164 | -8 | -169 | ||
Deferred revenue | ||||||
- | -20 | -51 | 71 | - | ||
Operating lease liabilities | ||||||
-258 | - | - | - | - | ||
Accrued and other liabilities | ||||||
5,125 | 4,165 | 1,666 | 1,829 | 1,119 | ||
Net cash used in operating activities | ||||||
-65,692 | -32,193 | -24,615 | -18,840 | - | ||
CASH FLOWS FROM INVESTING ACTIVITIES | ||||||
Net cash used in operating activities | ||||||
- | - | - | - | -10,982 | ||
Purchases of property and equipment | ||||||
1,492 | 422 | 619 | 212 | 208 | ||
Purchases of marketable securities | ||||||
91,926 | 62,179 | 64,115 | - | - | ||
Proceeds from maturities of marketable securities | ||||||
91,679 | 47,370 | 42,205 | - | - | ||
Purchases of marketable securities | ||||||
- | - | - | 20,390 | 3,766 | ||
Proceeds from maturities of marketable securities | ||||||
- | - | - | 8,446 | - | ||
Decrease in restricted cash | ||||||
- | - | - | -80 | 40 | ||
Net cash provided by investing activities | ||||||
-1,739 | -15,231 | -22,529 | -12,076 | - | ||
CASH FLOWS FROM FINANCING ACTIVITIES | ||||||
Proceeds from issuance of common stock and pre-funded warrants in public offering, net of offering costs | ||||||
64,298 | 54,048 | 11,380 | - | - | ||
Proceeds from issuance of common stock in public and at-the-market offerings, net of offering costs | ||||||
- | - | - | 49,294 | - | ||
Net cash used in investing activities | ||||||
- | - | - | - | -4,014 | ||
Proceeds from issuance of convertible preferred stock, net of offering costs | ||||||
- | - | - | - | 43,679 | ||
Proceeds from issuance of common stock in public offering, net of offering costs | ||||||
- | - | - | - | -2,028 | ||
Proceeds from employee stock plan purchases and stock option exercises | ||||||
1,450 | 3,020 | 833 | 76 | 23 | ||
Principal payments on finance lease obligation | ||||||
25 | - | - | - | - | ||
Net cash provided by financing activities | ||||||
65,723 | 57,068 | 12,213 | 49,370 | - | ||
NET (DECREASE) INCREASE IN CASH, CASH EQUIVALENTS, AND RESTRICTED CASH | ||||||
-1,708 | 9,644 | -34,931 | 18,454 | - | ||
CASH, CASH EQUIVALENTS, AND RESTRICTED CASH | ||||||
Net cash provided by financing activities | ||||||
- | - | - | - | 41,674 | ||
NET INCREASE (DECREASE) IN CASH AND CASH EQUIVALENTS | ||||||
- | - | - | - | 26,678 | ||
Supplemental Disclosure of Non-Cash Investing and Financing Information: | ||||||
Leased assets obtained in exchange for lease obligations | ||||||
5,294 | - | - | - | - | ||
Unpaid amounts related to purchase of property and equipment | ||||||
356 | 92 | 57 | 172 | - | ||
Deemed dividend to Series A convertible preferred stockholders upon conversion from an LLC to corporation | ||||||
- | - | - | - | 228 | ||
Convertible preferred stock issued for research and development services to be performed | ||||||
- | - | - | - | 232 | ||
Series A Convertible Preferred Stock | ||||||
Conversion of convertible preferred stock to common stock upon initial public offering | ||||||
- | - | - | 13,573 | - | ||
Series B Convertible Preferred Stock | ||||||
Conversion of convertible preferred stock to common stock upon initial public offering | ||||||
- | - | - | 44,738 | - | ||