| Dec'18 | Dec'17 | Dec'16 | Dec'15 | Dec'14 | Dec'13 | Dec'12 |
|---|---|---|---|---|---|---|
Revenues | ||||||
Total revenues | ||||||
8,728 | 11,175 | 41,773 | 26,061 | 19,970 | - | - |
Contract revenue | ||||||
- | - | - | - | - | 18,512 | 17,941 |
Operating expenses | ||||||
Cost of sales | ||||||
31 | - | - | - | - | - | - |
Research and development | ||||||
102,959 | 95,598 | 73,999 | 40,228 | 30,110 | 23,484 | 26,581 |
Selling, general and administrative | ||||||
71,385 | 41,903 | - | - | - | - | - |
Restructuring charges | ||||||
23,518 | - | - | - | - | - | - |
General and administrative | ||||||
- | - | 17,122 | 12,406 | 9,646 | 6,992 | 7,349 |
Total operating expenses | ||||||
197,893 | 137,501 | 91,121 | 52,634 | 39,756 | 30,476 | 33,930 |
Loss from operations | ||||||
-189,165 | -126,326 | -49,348 | -26,573 | -19,786 | -11,964 | -15,989 |
Interest expense | ||||||
2,112 | 2,855 | 2,320 | 699 | 397 | 1,331 | 2,427 |
Change in warrant and derivative liabilities | ||||||
9,053 | 1,928 | -19,859 | -19 | - | - | - |
Loss on debt extinguishment | ||||||
-819 | - | - | - | - | - | - |
Loss on settlement of contingently redeemable common stock | ||||||
-5,179 | - | - | - | - | - | - |
Other income, net | ||||||
1,710 | 1,635 | 300 | 198 | 7 | 183 | 51 |
Net loss | ||||||
-186,512 | -125,618 | -71,227 | -27,093 | -20,176 | -13,112 | -18,365 |
Net loss per common share: | ||||||
Basic | ||||||
-4.11 | -3.17 | - | - | - | - | - |
Diluted | ||||||
-4.25 | -3.17 | - | - | - | - | - |
Weighted-average shares used to calculate net loss per common share | ||||||
Basic | ||||||
45,384 | 39,645 | - | - | - | - | - |
Diluted | ||||||
46,027 | 39,645 | - | - | - | - | - |
Basic and diluted net loss per common share | ||||||
- | - | -3.00 | -1.49 | -1.42 | - | - |
Basic and diluted net loss per common share (in dollars per share) | ||||||
- | - | - | - | - | -33.83 | -52.77 |
Weighted-average common shares outstanding used to calculate basic and diluted net loss per common share | ||||||
- | - | 23,707 | 18,147 | 14,210 | 387 | 347 |
Product Revenue, Net | ||||||
Total revenues | ||||||
783 | - | - | - | - | - | - |
Contract Revenue | ||||||
Total revenues | ||||||
7,945 | 11,175 | - | - | - | - | - |