| Dec'19 | Dec'18 | Dec'17 | Dec'16 | Dec'15 | ||
|---|---|---|---|---|---|---|
Cash flows from operating activities: | ||||||
Net loss | ||||||
-47,339 | -35,648 | -21,650 | -24,507 | - | ||
Net loss | ||||||
- | - | - | - | -14,247 | ||
Adjustments to reconcile net loss to net cash used in operating activities: | ||||||
Stock-based compensation expense | ||||||
2,989 | 2,049 | 517 | 251 | 207 | ||
Depreciation expense | ||||||
163 | 78 | 73 | 46 | 98 | ||
Non-cash interest expense | ||||||
8 | 161 | 351 | 204 | 167 | ||
Non-cash lease expense | ||||||
486 | - | - | - | - | ||
Amortization of premium on investments | ||||||
- | - | 33 | 153 | - | ||
Loss on extinguishment of debt | ||||||
- | -617 | - | - | - | ||
Loss on disposal of equipment | ||||||
- | - | - | - | -7 | ||
Change in fair value of warrant liability | ||||||
- | - | 257 | 132 | 36 | ||
Changes in assets and liabilities: | ||||||
Prepaid expenses and other current assets | ||||||
202 | 1,287 | 984 | -343 | 639 | ||
Other assets | ||||||
-123 | 34 | 89 | - | - | ||
Accounts payable | ||||||
972 | 441 | 199 | -525 | 1,001 | ||
Accrued expenses | ||||||
-301 | 1,764 | 228 | - | - | ||
Accrued expenses | ||||||
- | - | - | 689 | 219 | ||
Operating lease liabilities | ||||||
-531 | - | - | - | - | ||
Other liabilities | ||||||
- | 20 | - | -180 | -24 | ||
Net cash used in operating activities | ||||||
-43,632 | -31,839 | -21,065 | -23,394 | - | ||
Cash flows from investing activities: | ||||||
Net cash used in operating activities | ||||||
- | - | - | - | -13,175 | ||
Purchases of property and equipment | ||||||
122 | 318 | 57 | 102 | - | ||
Purchases of investments | ||||||
- | - | 1,247 | 53,210 | - | ||
Maturities of investments | ||||||
- | - | 24,721 | 29,550 | - | ||
Sale of property and equipment | ||||||
- | - | - | - | 5 | ||
Net cash used in investing activities | ||||||
-122 | -318 | 23,417 | -23,762 | 5 | ||
Cash flows from financing activities: | ||||||
Proceeds from (payments of issuance costs) the issuance of common stock, net of issuance costs | ||||||
12,035 | -309 | 67,197 | - | - | ||
Proceeds from exercise of stock options | ||||||
36 | 139 | 28 | 19 | 7 | ||
Proceeds from issuance of stock through ESPP | ||||||
76 | 34 | - | - | - | ||
Proceeds from loan payable | ||||||
- | 10,000 | - | 10,000 | 3,250 | ||
Repayment of loan payable | ||||||
- | 10,492 | 333 | 6,256 | 744 | ||
Debt issuance costs paid | ||||||
- | 33 | - | 368 | - | ||
Other | ||||||
-29 | -33 | - | - | - | ||
Net cash (used in) provided by financing activities | ||||||
12,118 | -694 | 66,892 | 3,395 | - | ||
Net decrease in cash and cash equivalents | ||||||
-31,636 | -32,851 | 69,244 | -43,761 | - | ||
Supplemental disclosures: | ||||||
Cash paid for interest | ||||||
543 | 906 | 452 | - | - | ||
Net cash (used in) provided by financing activities | ||||||
- | - | - | - | 55,295 | ||
Net (decrease) increase in cash and cash equivalents | ||||||
- | - | - | - | 42,125 | ||
Cash paid for interest | ||||||
- | - | - | 472 | 193 | ||
Property and equipment purchases included in accounts payable | ||||||
- | 72 | 11 | 38 | 9 | ||
Right-of-use assets obtained in exchange of operating lease obligations | ||||||
992 | - | - | - | - | ||
Issuance costs included in accounts payable and accrued expenses | ||||||
45 | - | 199 | - | - | ||
Issuance of warrants in connection with loan payable | ||||||
- | - | - | 67 | 7 | ||
Accretion of convertible preferred stock to redemption value | ||||||
- | - | 58 | 69 | 37 | ||