| Dec'19 | Dec'18 | Dec'17 | Dec'16 | Dec'15 | Dec'14 | Dec'13 | Dec'12 | Dec'11 | Dec'10 |
|---|---|---|---|---|---|---|---|---|---|
Research grants and contracts | |||||||||
- | - | - | 2,826 | - | - | - | - | - | - |
License revenue | |||||||||
- | - | - | 410 | - | - | - | - | - | - |
Total revenue | |||||||||
- | - | - | 3,236 | - | - | - | - | - | - |
Revenue | |||||||||
5,801 | 10,331 | 10,738 | - | - | - | - | - | - | - |
Contract revenue | |||||||||
- | - | - | - | 10,640 | 10,190 | 17,912 | 25,175 | 24,266 | 20,993 |
Operating expenses: | |||||||||
Research and development | |||||||||
17,765 | 18,459 | 18,406 | 7,221 | 5,133 | 9,319 | 15,290 | 19,509 | 21,219 | 20,875 |
General and administrative | |||||||||
8,500 | 9,765 | 8,457 | 7,106 | 6,222 | 10,911 | 13,279 | 11,628 | 14,311 | 18,015 |
Impairment charges | |||||||||
1,000 | 24,940 | 35,919 | - | - | - | - | - | - | - |
Restructuring expense | |||||||||
- | - | - | - | 2,546 | 0 | 0 | - | - | - |
Depreciation | |||||||||
- | - | - | - | 141 | 149 | 182 | 303 | 461 | - |
Depreciation and amortization (including $4,635,489 impairment charges in 2010) | |||||||||
- | - | - | - | - | - | - | - | - | 5,655 |
Total operating expenses | |||||||||
27,266 | 53,165 | 62,783 | 14,327 | 14,043 | 20,381 | 28,751 | 31,442 | 35,992 | 44,547 |
Loss from operations | |||||||||
-21,464 | -42,834 | -52,045 | -11,091 | -3,402 | -10,191 | -10,839 | -6,266 | -11,725 | -23,553 |
Other income (expense): | |||||||||
Changes in fair value of warrant liability, including loss on exchange | |||||||||
30 | -2,878 | 97 | - | - | - | - | - | - | - |
Gain on sale of assets held for sale | |||||||||
- | - | - | - | - | - | - | - | 781 | 0 |
Realization of cumulative translation adjustment | |||||||||
- | - | - | - | - | - | - | -1,227 | 0 | 0 |
Changes in fair value of embedded derivative | |||||||||
- | 184 | -7 | - | 299 | 508 | -444 | 591 | 7,144 | -5,457 |
Interest expense | |||||||||
2 | 297 | 162 | 38 | - | - | 366 | 324 | 54 | 5,936 |
Interest income (expense), net | |||||||||
- | - | - | - | -54 | -210 | - | - | - | - |
Realization of cumulative translation adjustment | |||||||||
- | - | - | - | 229 | 0 | 0 | -1,227 | 0 | 0 |
Interest income | |||||||||
843 | 226 | 47 | 1 | - | - | - | - | 16 | 6 |
Other income - litigation | |||||||||
- | - | - | - | 0 | 0 | - | - | - | - |
Other income, net | |||||||||
15 | 277 | 5 | 42 | 8 | -0 | -6 | 47 | 39 | 91 |
Total other income, net | |||||||||
886 | -2,486 | -18 | 4 | 23 | 297 | -817 | 1,541 | 7,928 | -11,295 |
Net loss before income tax benefit | |||||||||
-20,578 | -45,320 | -52,063 | -11,086 | - | - | - | - | - | - |
Loss before income taxes | |||||||||
- | - | - | - | -3,378 | -9,893 | -11,656 | -4,724 | -3,797 | -34,849 |
Income tax benefit | |||||||||
-58 | -6,149 | -5,638 | 0 | 61 | 61 | 61 | 195 | - | - |
Income tax (provision) benefit | |||||||||
- | - | - | - | - | - | - | - | 0 | 0 |
Net loss | |||||||||
-20,520 | -39,171 | -46,425 | -11,086 | -3,440 | -9,955 | -11,718 | -4,920 | -3,797 | -34,849 |
Other comprehensive loss — foreign currency translation adjustment | |||||||||
- | -463 | 2,997 | - | - | - | - | - | - | - |
Other comprehensive loss – unrealized loss on investments | |||||||||
20 | - | - | - | - | - | - | - | - | - |
Comprehensive loss | |||||||||
-20,500 | -39,634 | - | - | - | - | - | - | - | - |
Other comprehensive income (loss) - foreign currency translation adjustments | |||||||||
- | - | - | 6,805 | - | - | - | - | - | - |
Comprehensive loss | |||||||||
- | - | -43,427 | -17,892 | - | - | - | - | - | - |
Net loss | |||||||||
-20,520 | -39,171 | -46,425 | -11,086 | - | - | - | - | - | - |
Preferred stock accretion and other deemed dividends | |||||||||
452 | 3,307 | 4,930 | 368 | - | - | - | - | - | - |
Net loss attributed to common stockholders | |||||||||
-20,973 | -42,478 | -51,355 | -11,455 | - | - | - | - | - | - |
Weighted-average common shares outstanding, basic and diluted | |||||||||
13,124 | 2,802 | 431 | 6,911 | - | - | 50,659 | 48,323 | 47,331 | 32,309 |
Net loss per share attributed to common stockholders, basic and diluted | |||||||||
-1.60 | -15.16 | -118.91 | -1.66 | - | - | -0.23 | -0.10 | -0.08 | -1.08 |
Basic net income (loss) per share | |||||||||
- | - | - | - | -0.05 | -0.17 | - | - | - | - |
Diluted net income (loss) per share | |||||||||
- | - | - | - | -0.05 | -0.17 | - | - | - | - |
Weighted-average shares used in calculation of basic net income (loss) per share | |||||||||
- | - | - | - | 63,986 | 57,535 | - | - | - | - |
Weighted-average shares used in calculation of diluted net income (loss) per share | |||||||||
- | - | - | - | 63,986 | 57,535 | - | - | - | - |
Research Grants and Contracts [Member] | |||||||||
Total revenue | |||||||||
- | - | 10,696 | - | - | - | - | - | - | - |
License Revenue [Member] | |||||||||
Total revenue | |||||||||
- | - | 41 | - | - | - | - | - | - | - |