| Dec'19 | Dec'18 | Dec'17 | Dec'16 | Dec'15 | Dec'14 | Dec'13 | Dec'12 | Dec'11 | Dec'10 | Dec'09 | Dec'08 |
|---|---|---|---|---|---|---|---|---|---|---|---|
Revenue from Contract with Customer [Abstract] | |||||||||||
Revenues: | |||||||||||
Revenues | |||||||||||
327,751 | 474,002 | 495,769 | 432,487 | - | - | - | - | - | - | - | - |
Product sales, net | |||||||||||
- | - | - | - | 341,816 | 109,998 | 71,692 | 58,287 | - | - | 16,482 | 751 |
Service revenues, net | |||||||||||
- | - | - | - | 24,132 | 0 | - | - | - | - | - | - |
License fee, collaboration and other revenues | |||||||||||
- | - | - | - | 52,328 | 14,386 | 9,164 | 26,475 | 8,321 | 6,132 | 516 | 959 |
U.S. Feraheme product sales, net | |||||||||||
- | - | - | - | - | - | - | - | 52,097 | 59,339 | - | - |
Other product sales and royalties | |||||||||||
- | - | - | - | - | - | - | 616 | 831 | 774 | - | - |
Royalties | |||||||||||
- | - | - | - | - | - | - | - | - | - | 180 | 228 |
Total revenues | |||||||||||
- | - | - | - | 418,276 | 124,384 | 80,856 | 85,378 | 61,249 | 66,245 | 17,178 | 1,938 |
Costs and expenses: | |||||||||||
Cost of product sales | |||||||||||
107,193 | 215,892 | 161,349 | 96,314 | - | - | - | - | - | - | - | - |
Cost of product sales | |||||||||||
- | - | - | - | 78,509 | 20,306 | 11,960 | 14,220 | 10,531 | 7,606 | 1,013 | 292 |
Cost of services | |||||||||||
- | - | - | - | 9,992 | 0 | - | - | - | - | - | - |
Research and development expenses | |||||||||||
64,853 | 44,846 | 75,017 | 65,561 | 42,878 | 24,160 | 20,564 | 33,296 | 58,140 | 54,462 | 36,273 | 31,716 |
Acquired in-process research and development | |||||||||||
74,856 | 32,500 | 65,845 | 0 | 0 | - | - | - | - | - | - | - |
Selling, general and administrative expenses | |||||||||||
286,600 | 227,810 | 178,151 | 169,468 | 160,309 | 72,254 | 59,167 | 53,071 | 68,863 | 84,939 | 77,829 | 49,536 |
Impairment of assets | |||||||||||
232,300 | 0 | 319,246 | - | - | - | - | - | - | - | - | - |
Impairment of Intangible Assets, Finite-lived | |||||||||||
- | - | - | 15,724 | 0 | 0 | - | - | - | - | - | - |
Acquisition-related costs | |||||||||||
- | - | - | - | 11,232 | 9,478 | 782 | - | - | - | - | - |
Restructuring expenses | |||||||||||
7,420 | 0 | 0 | 341 | 4,136 | 2,023 | - | 2,215 | 3,508 | 2,224 | - | - |
Total costs and expenses | |||||||||||
773,258 | 521,048 | 799,608 | 347,408 | 307,056 | 128,221 | 92,473 | 102,802 | 141,042 | 149,231 | 115,115 | 81,544 |
Operating loss | |||||||||||
-445,507 | -47,046 | -303,839 | 85,079 | 111,220 | -3,837 | -11,617 | -17,424 | - | - | - | - |
Other income (expense): | |||||||||||
Interest expense | |||||||||||
25,709 | 51,971 | 68,382 | 73,153 | 53,251 | 14,697 | - | - | - | - | - | - |
Gain (Loss) on Extinguishment of Debt | |||||||||||
0 | -35,922 | -10,926 | 0 | -10,449 | 0 | - | - | - | - | - | - |
Interest and dividend income | |||||||||||
4,285 | 5,328 | 2,810 | 3,149 | 1,512 | 975 | 1,051 | 1,286 | 1,747 | 1,741 | 3,154 | 9,139 |
Other income | |||||||||||
428 | -74 | -70 | 189 | -9,188 | 217 | 964 | - | - | - | - | - |
Total other (expense) income | |||||||||||
- | - | - | - | - | -13,505 | 2,015 | - | - | - | - | - |
Gains (losses) on investments, net | |||||||||||
- | - | - | - | - | - | - | -1,466 | -193 | 408 | 942 | -3,024 |
Fair value adjustment of settlement rights | |||||||||||
- | - | - | - | - | - | - | - | - | -788 | -778 | 1,566 |
Total other expense, net | |||||||||||
-20,996 | -82,639 | -76,568 | -69,815 | -71,376 | - | - | -180 | 1,554 | 1,361 | 3,318 | 7,681 |
Loss from continuing operations before income taxes | |||||||||||
-466,503 | -129,685 | -380,407 | 15,264 | 39,844 | -17,342 | -9,602 | -17,604 | -78,239 | -81,625 | -94,619 | -71,925 |
Income tax expense (benefit) | |||||||||||
-47 | 39,700 | -175,300 | 13,200 | 7,065 | -153,159 | - | -854 | -1,170 | -472 | -1,268 | -278 |
Income (Loss) from Continuing Operations, Net of Tax, Attributable to Parent | |||||||||||
-466,456 | -169,339 | -205,153 | 2,093 | - | - | - | - | - | - | - | - |
Discontinued Operations and Disposal Groups [Abstract] | |||||||||||
Discontinued Operation, Income (Loss) from Discontinued Operation, before Income Tax | |||||||||||
0 | 18,873 | 10,313 | -6,209 | - | - | - | - | - | - | - | - |
Gain on sale of CBR business | |||||||||||
0 | 87,076 | 0 | 0 | - | - | - | - | - | - | - | - |
Income tax expense | |||||||||||
0 | 2,371 | 4,388 | -1,633 | - | - | - | - | - | - | - | - |
Income (Loss) from Discontinued Operations, Net of Tax, Attributable to Parent | |||||||||||
0 | 103,578 | 5,925 | -4,576 | - | - | - | - | - | - | - | - |
Net loss | |||||||||||
-466,456 | -65,761 | -199,228 | -2,483 | 32,779 | 135,817 | -9,602 | -16,750 | -77,069 | -81,153 | -93,351 | -71,647 |
Basic and diluted earnings per share: | |||||||||||
(Loss) income from continuing operations (in dollars per share) | |||||||||||
- | - | - | 0.06 | - | - | - | - | - | - | - | - |
Income (Loss) from Discontinued Operations and Disposal of Discontinued Operations, Net of Tax, Per Basic Share | |||||||||||
- | - | - | -0.13 | - | - | - | - | - | - | - | - |
Total (in dollars per share) | |||||||||||
- | - | - | -0.07 | 1.04 | 6.06 | -0.44 | -0.78 | - | - | - | -4.22 |
(Loss) income from continuing operations (in dollars per share) | |||||||||||
- | - | - | 0.06 | - | - | - | - | - | - | - | - |
Income (loss) from discontinued operations (in dollars per share) | |||||||||||
- | - | - | -0.13 | - | - | - | - | - | - | - | - |
Total (in dollars per share) | |||||||||||
- | - | - | -0.07 | 0.93 | 5.45 | -0.44 | -0.78 | - | - | - | -4.22 |
Loss from continuing operations (in dollars per share) | |||||||||||
-13.71 | -4.92 | -5.88 | - | - | - | - | - | -3.64 | -3.90 | -5.46 | - |
Income (Loss) from Discontinued Operations and Disposal of Discontinued Operations, Net of Tax, Per Basic and Diluted Share | |||||||||||
0.00 | 3.01 | 0.17 | - | - | - | - | - | - | - | - | - |
Basic and diluted net loss per share (in dollars per share) | |||||||||||
-13.71 | -1.91 | -5.71 | - | - | - | - | - | - | - | - | - |
Weighted Average Number of Shares Outstanding, Basic | |||||||||||
34,030 | 34,394 | 34,907 | 34,346 | 31,471 | 22,416 | 21,703 | - | - | - | 17,109 | 16,993 |
Weighted average shares outstanding used to compute net loss per share (basic and diluted) (in shares) | |||||||||||
- | - | - | - | - | - | - | 21,392 | 21,189 | 20,806 | - | - |
Weighted Average Number of Shares Outstanding, Diluted | |||||||||||
- | - | - | 34,833 | 35,308 | 25,225 | 21,703 | 21,392 | - | - | 17,109 | 16,993 |
Product Sales | |||||||||||
Revenues | |||||||||||
311,190 | 473,852 | 495,645 | 432,170 | - | - | - | - | - | - | - | - |
Collaboration revenue | |||||||||||
Revenue from Contract with Customer, Excluding Assessed Tax | |||||||||||
16,400 | 0 | 0 | - | - | - | - | - | - | - | - | - |
Other revenues | |||||||||||
Revenues | |||||||||||
161 | 150 | 124 | 317 | - | - | - | - | - | - | - | - |