| Mar'20 | Dec'19 | Sep'19 | Jun'19 | Mar'19 | Dec'18 | Sep'18 | Jun'18 | Mar'18 | Dec'17 | Sep'17 | Jun'17 | Mar'17 | Dec'16 | Sep'16 | Jun'16 | Mar'16 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
CASH FLOWS FROM OPERATING ACTIVITIES: | ||||||||||||||||
Net Income (Loss) Attributable to Parent | ||||||||||||||||
-83,520 | -97,336 | -94,067 | -78,992 | -68,648 | -61,656 | -51,523 | -44,655 | -33,721 | -30,070 | -27,787 | -19,812 | -14,806 | -4,259 | 0 | 0 | 0 |
Adjustments to reconcile net loss to net cash used in operating activities: | ||||||||||||||||
Depreciation and amortization | ||||||||||||||||
539 | 514 | 480 | 436 | 376 | 315 | 256 | 211 | 198 | 183 | 194 | 206 | 215 | 233 | 0 | 0 | 0 |
Stock-based compensation | ||||||||||||||||
12,519 | 12,411 | 12,275 | 11,663 | 10,568 | 9,961 | 8,472 | 6,882 | 5,772 | 4,378 | 3,534 | 2,847 | 1,704 | 1,160 | 0 | 0 | 0 |
Fair Value Adjustment of Warrants | ||||||||||||||||
- | - | - | - | - | - | - | - | - | 1,366 | 2,457 | 2,504 | 2,501 | 756 | 0 | 0 | 0 |
Accretion/amortization of investments, net | ||||||||||||||||
1,613 | 2,633 | 3,127 | 2,904 | 2,178 | 1,233 | 0 | 0 | 0 | - | - | - | - | - | - | - | - |
(Income) loss from investments | ||||||||||||||||
- | - | - | - | - | - | - | - | - | - | - | - | 0 | - | - | - | - |
Non-cash interest expense | ||||||||||||||||
-512 | -676 | -668 | -661 | -654 | -646 | -640 | -633 | -625 | -619 | -485 | -358 | -233 | -105 | 0 | 0 | 0 |
Income taxes | ||||||||||||||||
- | - | - | - | - | - | - | - | - | - | - | - | - | -139 | 0 | 0 | 0 |
Changes in operating assets and liabilities: | ||||||||||||||||
Receivable from collaborative partners | ||||||||||||||||
5,000 | 0 | 0 | 0 | 0 | - | - | - | - | -1,225 | -860 | -980 | -1,191 | -1 | 0 | 0 | 0 |
Australian tax incentive receivable | ||||||||||||||||
- | - | - | - | - | -1,427 | -1,313 | -5,485 | -3,355 | -2,517 | -1,807 | 3,039 | 4,965 | 4,118 | 0 | 0 | 0 |
Prepaid expenses and other assets | ||||||||||||||||
-3,626 | -2,178 | 1,860 | 2,567 | 6,791 | 5,188 | 1,707 | 581 | 1,354 | 1,885 | 2,149 | 3,197 | 906 | 1,079 | 0 | 0 | 0 |
Accounts payable and other liabilities | ||||||||||||||||
4,233 | 14,499 | 14,317 | 17,646 | 12,317 | 7,083 | 7,083 | 2,215 | 1,378 | 2,218 | 1,913 | 2,652 | 3,026 | 1,251 | 0 | 0 | 0 |
Deferred revenue | ||||||||||||||||
- | - | - | - | - | - | - | - | - | - | - | - | - | -2,942 | 0 | 0 | 0 |
Net cash used in operating activities | ||||||||||||||||
-68,530 | -69,517 | -66,002 | -58,766 | -52,127 | -48,506 | -41,026 | -30,054 | -23,819 | -19,438 | -20,198 | -19,383 | -15,071 | -9,030 | 0 | 0 | 0 |
CASH FLOWS FROM INVESTING ACTIVITIES: | ||||||||||||||||
Acquisition of investments | ||||||||||||||||
246,065 | 251,815 | 398,591 | 389,439 | 395,097 | 347,537 | 304,199 | 291,963 | 296,108 | 290,905 | 110,701 | 89,353 | 27,000 | 0 | 0 | 0 | 0 |
Sales and maturities of investments | ||||||||||||||||
379,302 | 384,051 | 360,744 | 316,385 | 261,168 | 206,149 | 175,822 | 138,168 | 82,718 | 48,137 | 0 | 0 | 0 | - | - | - | - |
Purchases of property and equipment | ||||||||||||||||
712 | 805 | 907 | 948 | 1,011 | 1,063 | 981 | 673 | 437 | 290 | 167 | 154 | 100 | 50 | 0 | 0 | 0 |
Net cash provided by investing activities | ||||||||||||||||
132,525 | 131,431 | -38,754 | -74,002 | -134,940 | -142,451 | -129,358 | -154,468 | -213,827 | -243,058 | -90,002 | -89,507 | -27,100 | -50 | 0 | 0 | 0 |
CASH FLOWS FROM FINANCING ACTIVITIES: | ||||||||||||||||
Proceeds from Issuance of Common Stock | ||||||||||||||||
- | - | - | - | - | - | - | - | - | 292,537 | 80,213 | 80,213 | 80,213 | 0 | 0 | 0 | 0 |
Proceeds from issuance of common stock, upon the exercise of stock options | ||||||||||||||||
2,462 | 3,000 | 1,974 | 2,189 | 3,371 | 2,869 | 2,303 | 1,945 | 696 | 979 | 829 | 525 | 377 | 31 | 0 | 0 | 0 |
Proceeds from issuance of common stock, upon the exercise of warrants | ||||||||||||||||
- | - | - | - | - | 76 | 76 | 77 | 76 | 536 | 536 | 535 | 535 | 0 | 0 | 0 | 0 |
Payments on notes payable | ||||||||||||||||
7,000 | 7,500 | 7,500 | 7,500 | 7,500 | 6,875 | 5,000 | 3,125 | 1,250 | 0 | 0 | 0 | 0 | - | - | - | - |
Payments for repurchase of common stock | ||||||||||||||||
- | - | - | - | - | - | - | - | - | - | - | - | - | 1 | 0 | 0 | 0 |
Payments for offering costs, net | ||||||||||||||||
- | - | - | - | - | - | - | 0 | 0 | - | - | 1,962 | 1,263 | 1,147 | 0 | 0 | 0 |
Net cash used in financing activities | ||||||||||||||||
-4,531 | -4,493 | -5,754 | 222,263 | 223,446 | 223,364 | 437,123 | 210,827 | 210,366 | 292,453 | 89,735 | 89,056 | 89,607 | 8,628 | 0 | 0 | 0 |
Net decrease in cash, cash equivalents, and restricted cash | ||||||||||||||||
59,464 | 57,421 | -110,510 | 89,495 | 36,379 | 32,407 | 266,739 | 26,305 | -27,280 | 29,957 | -20,465 | -19,834 | 47,436 | -452 | 0 | 0 | 0 |
SUPPLEMENTAL DISCLOSURE OF CASH FLOW INFORMATION | ||||||||||||||||
Interest paid | ||||||||||||||||
256 | 424 | 592 | 759 | 918 | 1,043 | 1,162 | 1,205 | 1,108 | 1,089 | 855 | 649 | 545 | 354 | 0 | 0 | 0 |
Non-cash investing and financing activities: | ||||||||||||||||
Amounts accrued for property and equipment | ||||||||||||||||
-106 | 41 | 81 | -21 | 385 | 159 | 339 | 376 | 146 | 191 | 116 | 113 | 149 | 104 | 0 | 0 | 0 |
Amounts accrued for offering costs | ||||||||||||||||
- | - | - | - | - | - | - | - | - | - | - | - | 1,879 | 849 | 0 | 0 | 0 |
Reclassification of warrants to equity | ||||||||||||||||
- | - | - | - | - | - | - | - | - | 4,607 | 4,607 | 4,607 | 4,607 | 0 | 0 | 0 | 0 |