| Dec'19 | Dec'18 | Dec'17 | Dec'16 | Dec'15 | Dec'14 | Dec'13 | Dec'12 | Dec'11 | Dec'10 | Dec'09 |
|---|---|---|---|---|---|---|---|---|---|---|
Operating Activities: | ||||||||||
Net income (loss) | ||||||||||
397,555 | -29,399 | -92,732 | -22,896 | -107,979 | -60,508 | -19,435 | -85,477 | -109,224 | -124,534 | -153,204 |
Adjustments to reconcile net income (loss) to net cash provided by (used in) operating activities: | ||||||||||
(Income) loss from discontinued operations | ||||||||||
- | -830 | 3,122 | -10,596 | 2,728 | - | - | - | - | - | - |
Depreciation and amortization | ||||||||||
3,233 | 3,759 | 4,278 | 4,994 | 5,430 | 8,655 | 7,733 | 9,055 | 10,127 | 10,393 | 11,018 |
Deferred income taxes | ||||||||||
110,333 | -110,333 | - | - | - | - | - | - | - | - | -627 |
Non-cash collaboration revenue | ||||||||||
- | 1,500 | - | - | - | - | - | - | - | - | - |
Non-cash royalty revenue | ||||||||||
-3,744 | 3,315 | - | - | - | - | - | - | - | - | - |
Amortization of intangibles | ||||||||||
- | - | - | - | - | 506 | 469 | 691 | 997 | 2,159 | 3,508 |
Share-based compensation | ||||||||||
53,047 | 19,543 | 7,855 | 11,075 | 14,112 | 13,509 | 9,024 | 5,072 | 3,748 | 5,495 | 7,149 |
Gain from valuation of derivative liabilities | ||||||||||
- | - | - | - | 474 | 4,418 | 10,150 | -13,425 | 47 | 4,371 | 5,418 |
Litigation settlement expense, net | ||||||||||
- | - | 11,975 | - | - | - | - | - | - | - | - |
Gain on sale of available-for-sale securities | ||||||||||
- | - | - | - | - | 49,553 | 0 | 0 | - | - | - |
Amortization of short-term investment premium | ||||||||||
- | - | - | - | - | - | - | - | - | - | 69 |
Amortization of prepaid financing costs | ||||||||||
90 | 110 | 136 | 136 | 136 | 136 | 136 | 292 | 438 | 545 | 338 |
Amortization of original issue discounts, net of premiums, on available-for-sale investments | ||||||||||
5,628 | 664 | - | - | - | - | - | - | - | - | - |
Investment write-down | ||||||||||
- | - | - | - | - | - | - | - | 1,963 | 0 | 0 |
Loss on extinguishment of debt | ||||||||||
- | - | - | - | - | - | - | -6,338 | -10,514 | -12,354 | -2,479 |
Loss (gain) on disposal of property and equipment | ||||||||||
-112 | 791 | 379 | -1,270 | -1,007 | -172 | -49 | 31 | -18 | 14 | -313 |
Changes in operating assets and liabilities: | ||||||||||
Accounts receivable | ||||||||||
-3,432 | 2,760 | -10,787 | 12,246 | -781 | -6,407 | 4,473 | 5,260 | -2,878 | 1,931 | -430 |
Inventory | ||||||||||
- | - | - | - | - | -870 | 6,065 | 5,875 | 0 | 0 | - |
Prepaid expenses and other assets | ||||||||||
8,133 | 2,929 | -585 | -2,416 | 641 | 772 | 65 | 1,524 | -539 | -1,608 | 929 |
Payables and accrued liabilities | ||||||||||
12,347 | 10,871 | 1,803 | 2,410 | -2,092 | 13,240 | 19,572 | 276 | -1,117 | -5,644 | -28,765 |
Accrued litigation settlement | ||||||||||
- | -11,975 | - | - | - | - | - | - | - | - | - |
Deferred revenues | ||||||||||
-1,438 | -2,061 | -4,401 | -69,078 | -4,647 | -29,764 | 75,880 | 17,849 | -3,395 | 43,991 | 37 |
Deferred rent | ||||||||||
- | - | - | - | - | 122 | 125 | -103 | -187 | -152 | -129 |
Other long-term liabilities | ||||||||||
- | -1,265 | -577 | 30 | 101 | - | - | - | - | - | - |
Net cash provided by (used in) operating activities - continuing operations | ||||||||||
568,694 | -131,879 | -63,792 | -71,293 | -96,994 | -101,398 | - | -44,047 | - | - | - |
Net cash used in operating activities - discontinued operations | ||||||||||
- | -333 | -2,850 | 9,817 | -1,119 | - | - | - | - | - | - |
Net cash provided by (used in) operating activities | ||||||||||
568,694 | -132,212 | -66,642 | -61,476 | -98,113 | - | 72,800 | - | -78,257 | -52,315 | -155,925 |
Investing Activities: | ||||||||||
Proceeds from sale of available-for-sale securities | ||||||||||
- | - | - | - | - | 49,553 | 0 | 0 | - | - | - |
Purchases of available-for-sale investments | ||||||||||
1,469,220 | 364,539 | 112,615 | - | - | - | - | - | - | 1,231 | 20,433 |
Proceeds from sale and maturity of available-for-sale investments | ||||||||||
976,093 | 110,564 | - | - | - | - | - | - | - | - | - |
Deconsolidation of variable interest entity | ||||||||||
- | - | 406 | - | - | - | - | - | - | - | - |
Proceeds from sales/maturities of short-term investments, available-for-sale | ||||||||||
- | - | - | - | - | - | - | - | - | 21,664 | 36,696 |
Purchases of property and equipment | ||||||||||
4,819 | 692 | 113 | 814 | 1,119 | 8,905 | 9,164 | 1,777 | 619 | 4,211 | 5,331 |
Proceeds from sale of property and equipment | ||||||||||
- | - | 789 | 954 | 2,232 | 47 | 60 | 31 | 33 | 47 | - |
Proceeds from sale of equipment | ||||||||||
- | - | - | - | - | - | - | - | - | - | 263 |
Other non-current assets | ||||||||||
- | 11 | 5 | 654 | -609 | -209 | -439 | 425 | 86 | -48 | -170 |
Net cash used in investing activities - continuing operations | ||||||||||
-497,946 | -254,678 | -112,350 | -514 | 1,722 | 40,904 | - | -2,171 | - | - | - |
Net cash provided by (used in) investing activities - discontinued operations | ||||||||||
997 | 3,405 | -40 | -236 | -9,873 | - | - | - | - | - | - |
Net cash provided by (used in) investing activities | ||||||||||
-496,949 | -251,273 | -112,390 | -750 | -8,151 | - | -8,665 | - | -672 | 16,317 | 11,365 |
Financing Activities: | ||||||||||
Proceeds from issuance of note payable and related financial instruments to Deerfield | ||||||||||
- | - | - | - | - | - | - | - | - | - | 96,865 |
Proceeds from lease financing | ||||||||||
- | - | - | - | - | - | - | - | - | - | 15,000 |
Principal payments on lease financing obligations | ||||||||||
3,282 | 4,000 | 3,518 | 2,979 | 2,492 | 2,057 | 1,664 | 1,313 | 998 | 717 | 581 |
Proceeds from issuance of common stock, net | ||||||||||
13,147 | 389,031 | 248,805 | 370 | 103,628 | 5,225 | 3,315 | 151,218 | 17,977 | 120,466 | 65,368 |
Other financing activities | ||||||||||
- | - | - | 320 | - | - | - | - | - | - | - |
Proceeds from issuance of preferred stock | ||||||||||
- | - | - | - | - | - | - | 16,462 | 17,662 | 0 | 0 |
Net cash provided by (used in) financing activities | ||||||||||
- | - | - | - | - | 3,168 | - | 144,106 | - | - | - |
Net cash provided by financing activities | ||||||||||
9,865 | 385,031 | 245,287 | -2,289 | 101,136 | - | 1,651 | - | -14,158 | 89,749 | 166,652 |
Effect of exchange rate changes on cash | ||||||||||
-10 | 654 | 1,870 | -294 | -1,897 | -1,343 | 1 | 571 | 50 | 2,185 | -688 |
Net increase (decrease) in cash, cash equivalents and restricted cash | ||||||||||
81,600 | 2,200 | 68,125 | -64,809 | -7,025 | -58,669 | 65,787 | 98,459 | -93,037 | 55,936 | 21,404 |
Supplemental disclosure of cash flow information: | ||||||||||
Interest paid | ||||||||||
4,787 | 5,696 | 5,967 | 6,303 | 6,562 | 6,778 | 6,954 | 7,670 | 9,492 | 13,434 | 10,297 |
Supplemental disclosure of non-cash investing and financing information: | ||||||||||
Disposition of property and land upon lease expiration | ||||||||||
- | 3,944 | - | - | - | - | - | - | - | - | - |
Reduction in lease financing obligation from release of residual value upon lease expiration | ||||||||||
- | 5,039 | - | - | - | - | - | - | - | - | - |
Conversion of preferred stock into common stock | ||||||||||
- | - | - | - | - | - | - | 14,561 | 15,413 | 0 | 0 |
Deemed dividend related to beneficial conversion feature of convertible preferred stock | ||||||||||
- | - | - | - | - | - | - | 2,824 | 2,260 | 0 | 0 |
Retirement of treasury stock | ||||||||||
- | - | - | - | - | - | - | 23,070 | 0 | 0 | - |
Payable to Siegfried for acquisition of land and building | ||||||||||
- | - | - | - | - | - | - | 110 | 46 | 12 | 79 |