| Dec'18 | Dec'17 | Dec'16 | Dec'15 | Dec'14 | Dec'13 | Dec'12 | Dec'11 | Dec'10 | Dec'09 |
|---|---|---|---|---|---|---|---|---|---|
Revenue: | |||||||||
Research and development revenue | |||||||||
25,764 | - | 4,709 | 11,239 | 11,254 | 15,914 | 36,414 | 47,310 | 29,221 | 25,198 |
Costs and expenses: | |||||||||
Research and development | |||||||||
28,710 | 19,468 | 20,042 | 15,561 | 22,271 | 27,555 | 33,966 | 45,011 | 47,034 | 49,495 |
General and administrative | |||||||||
10,753 | 7,551 | 7,563 | 9,830 | 12,154 | 12,836 | 13,852 | 13,373 | 13,477 | 13,317 |
Restructuring and other costs | |||||||||
- | - | - | - | 1,099 | 650 | 0 | - | - | - |
Total costs and expenses | |||||||||
39,463 | 27,019 | 27,605 | 25,391 | 35,524 | 41,041 | 47,818 | 58,384 | 60,511 | 62,812 |
Loss from operations | |||||||||
-13,699 | -27,019 | -22,896 | -14,152 | -24,270 | -25,127 | -11,404 | -11,074 | -31,290 | -37,614 |
Interest income | |||||||||
1,435 | 238 | 178 | 101 | 272 | 502 | 445 | 317 | 619 | 1,089 |
Interest expense | |||||||||
1,666 | 1,520 | - | - | 35 | 32 | 26 | 25 | 274 | 655 |
Other income (expense) | |||||||||
-1,552 | -902 | - | 277 | 642 | 57 | 113 | 20 | 266 | 1,594 |
Loss before income taxes | |||||||||
-15,482 | -29,203 | -22,718 | -13,774 | -23,391 | -24,600 | -10,872 | -10,762 | -30,679 | -35,586 |
Provision for income taxes | |||||||||
0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | -550 | 550 |
Net loss | |||||||||
-15,482 | -29,203 | -22,718 | -13,774 | -23,391 | -24,600 | -10,872 | -10,762 | -30,129 | -36,136 |
Unrealized gain (loss) on marketable securities | |||||||||
-79 | -18 | -1 | 13 | -77 | -35 | 108 | 1 | -62 | - |
Comprehensive loss | |||||||||
-15,561 | -29,221 | -22,719 | -13,761 | -23,468 | -24,635 | -10,764 | -10,761 | -30,191 | - |
Basic and diluted net income (loss) per share: | |||||||||
Weighted average common shares used in calculating: | |||||||||
Net loss per share (in dollars per share) | |||||||||
-0.16 | -0.39 | -0.33 | -0.22 | -0.37 | -0.39 | -0.18 | 0.20 | -0.68 | -0.82 |
Weighted average basic and diluted common shares outstanding (in shares) | |||||||||
99,035 | 74,813 | 69,714 | 62,808 | 62,627 | 62 | 59 | 52,778 | 44,529 | 44,169 |