| Dec'19 | Dec'18 | Dec'17 | Dec'16 | Dec'15 | Dec'14 | Dec'13 | Dec'12 | Dec'11 | Dec'10 | Dec'09 |
|---|---|---|---|---|---|---|---|---|---|---|
Collaboration revenue | ||||||||||
15,963 | 14,804 | 9,019 | 0 | - | - | - | - | - | - | - |
Collaboration revenue | ||||||||||
- | - | - | - | 0 | - | - | - | - | - | - |
Operating expenses: | ||||||||||
Research and development | ||||||||||
85,757 | 72,741 | 44,225 | 33,093 | 18,357 | 10,716 | 15,029 | 19,514 | 25,277 | 1,850 | 2,942 |
General and administrative | ||||||||||
32,919 | 34,798 | 17,021 | 12,185 | 11,297 | 13,239 | 4,575 | 5,341 | 8,724 | 2,915 | 397 |
Total operating expenses | ||||||||||
118,676 | 107,539 | 61,246 | - | - | - | - | - | - | - | - |
Total operating expenses | ||||||||||
- | - | - | 45,278 | 29,655 | 23,956 | 19,604 | - | - | - | - |
Loss from operations | ||||||||||
-102,713 | -92,735 | -52,227 | -45,278 | -29,655 | -23,956 | -19,604 | -24,855 | -34,002 | -4,766 | -3,340 |
Other income | ||||||||||
Interest and other income, net | ||||||||||
4,300 | 3,083 | 983 | 1,539 | 1,228 | 167 | 201 | - | - | - | - |
Other income (expense), net | ||||||||||
5 | - | -615 | - | - | - | - | - | - | - | - |
Loss on sale of marketable securities | ||||||||||
- | - | - | -1,140 | - | - | - | - | - | - | - |
Realized loss from marketable securities | ||||||||||
- | - | - | - | -27 | 0 | - | - | - | - | - |
Beneficial conversion feature | ||||||||||
- | - | - | - | - | - | - | 0 | 0 | 6,001 | - |
Amortization of debt discount and warrants | ||||||||||
- | - | - | - | - | - | - | 0 | 302 | 2,484 | 78 |
Interest expense | ||||||||||
- | - | - | - | - | - | - | 0 | 116 | 2,043 | - |
Total other income | ||||||||||
4,305 | 3,083 | 368 | 399 | 1,201 | 167 | 201 | 65 | -342 | -10,524 | -1,199 |
Loss before income taxes | ||||||||||
-98,408 | -89,652 | -51,859 | -44,879 | -28,453 | -23,788 | - | - | - | - | - |
Income tax benefit | ||||||||||
-774 | 1,099 | -9,050 | -618 | 0 | 0 | - | - | - | - | - |
Interest income | ||||||||||
- | - | - | - | - | - | - | 65 | 76 | 5 | 0 |
Interest Expense | ||||||||||
- | - | - | - | - | - | - | - | - | - | 1,120 |
Net loss | ||||||||||
-97,634 | -90,751 | -42,809 | -44,261 | -28,453 | -23,788 | -19,403 | -24,790 | -34,344 | -15,290 | -4,539 |
Other comprehensive (loss) income | ||||||||||
Unrealized loss recognized in accumulated other comprehensive loss before reclassification, net of tax benefit of $50,664, $31,844, $44,192 and $89,281, respectively | ||||||||||
146 | 45 | 209 | 221 | -848 | 0 | - | - | - | - | - |
Reclassification adjustment of unrealized loss included in net loss, net of tax expense of $56,139, $37,987, $56,139 and $221,358, respectively | ||||||||||
- | - | - | - | 27 | 0 | - | - | - | - | - |
Comprehensive loss | ||||||||||
-97,488 | -90,706 | -42,600 | -44,040 | -29,275 | -23,788 | - | - | - | - | - |
Net loss per share, basic and diluted | ||||||||||
-3.72 | -3.98 | -2.41 | -2.57 | -1.81 | -3.40 | -5.00 | -1.94 | -3.57 | -24.67 | -10.02 |
Weighted average common shares outstanding, basic and diluted | ||||||||||
26,258 | 22,801 | 17,750 | 17,226 | 15,702 | 6,998 | 3,878 | 12,726 | 9,613 | 619 | 445 |