| Dec'19 | Dec'18 | Dec'17 | Dec'16 | Dec'15 | Dec'14 | Dec'13 | Dec'12 | Dec'11 | Dec'10 | Dec'09 |
|---|---|---|---|---|---|---|---|---|---|---|
Operating Activities | ||||||||||
Net (loss) income | ||||||||||
-217,201 | 36,908 | -102,496 | -88,720 | -75,738 | 131,762 | 43,313 | -29,781 | 70,726 | 3,896 | -22,008 |
Adjustments to reconcile net income (loss) to net cash provided by (used in) operating activities | ||||||||||
Gain (Loss) on sale of assets | ||||||||||
0 | 0 | 17,064 | 0 | - | - | - | - | - | - | - |
Intraperiod tax allocations | ||||||||||
-5,767 | 0 | 0 | - | - | - | - | - | - | - | - |
Change in fair value of contingent consideration | ||||||||||
- | - | - | 1,637 | -1,584 | 2,791 | 909 | - | - | - | - |
Deferred income tax benefit | ||||||||||
- | - | - | 23,632 | -41,354 | 87,378 | -103,202 | - | - | - | - |
Loss on extinguishment of convertible notes | ||||||||||
26,385 | 0 | -5,938 | -5,777 | - | - | - | - | - | - | - |
Non-cash interest expense on PDL liability | ||||||||||
- | - | - | - | - | 14,646 | 4,488 | - | - | - | - |
Non-cash PDL royalty revenue | ||||||||||
- | - | - | - | - | 242,808 | 18,104 | - | - | - | - |
Depreciation and amortization | ||||||||||
102,946 | 106,426 | 105,502 | 109,375 | 85,737 | 12,025 | 6,161 | 2,561 | 399 | 520 | 808 |
Amortization of Debt Issuance Costs and Discounts | ||||||||||
23,764 | 21,877 | 19,415 | 17,673 | 15,629 | 4,200 | - | - | - | - | - |
Recurring fair value measurement of assets and liabilities | ||||||||||
1,715 | 391 | 8,024 | - | - | - | - | - | - | - | - |
Loss on impairment of intangible asset | ||||||||||
189,790 | 0 | 0 | - | - | - | - | - | - | - | - |
Provision for inventory obsolescence | ||||||||||
- | - | - | 1,179 | 224 | - | 347 | 584 | - | - | - |
Allowance for inventory obsolescence | ||||||||||
- | - | - | - | - | - | - | - | -809 | 337 | - |
Loss (gain) on disposal of equipment | ||||||||||
-10,076 | -669 | 271 | 0 | -38 | -19 | - | -28 | - | - | 0 |
Stock-based compensation | ||||||||||
10,596 | 12,585 | 13,016 | 17,172 | 14,228 | 8,930 | 6,109 | 5,070 | 3,869 | 2,031 | 2,656 |
Provision for inventory and other assets | ||||||||||
5,304 | 598 | 2,673 | - | - | - | - | - | - | - | - |
Acquired in-process research and development | ||||||||||
0 | 0 | 24,900 | 0 | 25,000 | - | - | - | - | - | - |
Excess tax benefit from stock-based compensation | ||||||||||
- | - | - | - | - | 3,190 | -347 | - | - | - | - |
Other | ||||||||||
327 | -1,023 | -240 | -611 | -358 | -288 | - | - | - | - | - |
Changes in assets and liabilities: | ||||||||||
Accounts receivable | ||||||||||
5,533 | -35,271 | -30,107 | 30,902 | 44,117 | 15,453 | 7,838 | -807 | -1,673 | 1,316 | 1,259 |
Receivables from collaborative partners | ||||||||||
- | - | - | - | -508 | -10,170 | 726 | 1,943 | 7,881 | 98 | - |
Inventories | ||||||||||
316 | -9,048 | 1,873 | 3,718 | -9,329 | -1,689 | -4,266 | 2,346 | 3,016 | -658 | -283 |
Prepaid and other assets | ||||||||||
-40,769 | 56,136 | 5,114 | 2,464 | -6,085 | 2,190 | -1,540 | 1,509 | 4,031 | 145 | -4,219 |
Income taxes receivable | ||||||||||
- | - | - | -6,359 | 2,332 | 4,030 | - | - | - | - | - |
Accounts payable and other accrued liabilities | ||||||||||
-15,146 | -33,610 | -6,436 | 5,862 | 59,019 | -4,579 | 7,348 | 5,661 | 7,811 | 3,075 | 2,485 |
Accrued rebates, returns and discounts | ||||||||||
-16,816 | -60,069 | 4,292 | 10,478 | 85,348 | 17,143 | 3,485 | - | - | - | - |
Interest payable | ||||||||||
-3,270 | -1,576 | -2,705 | -2,747 | 15,992 | 2,683 | - | - | - | - | - |
Accrued compensation | ||||||||||
- | - | - | - | - | - | 2,063 | 1,780 | 597 | 234 | -197 |
Income taxes payable | ||||||||||
-294 | -126 | 67 | 59 | - | -61,875 | 62,222 | - | - | - | - |
Deferred revenue | ||||||||||
- | - | - | - | - | -15,516 | -3,273 | -12,136 | -11,708 | -11,492 | 14,851 |
Amortization of investments | ||||||||||
- | - | - | - | - | - | -783 | -331 | -21 | 81 | - |
Gain on bargain purchase | ||||||||||
- | - | - | - | - | - | 484 | 92 | - | - | - |
Net cash (used in) provided by operating activities | ||||||||||
90,475 | 72,497 | 62,167 | 71,263 | 152,370 | -55,917 | 9,754 | -30,985 | 57,651 | -2,381 | 1,838 |
Investing Activities | ||||||||||
Purchases of property and equipment | ||||||||||
1,481 | 5,507 | 666 | 2,860 | 1,715 | 599 | 1,812 | 6,880 | 698 | 179 | 629 |
Investment in convertible instrument | ||||||||||
0 | 3,000 | 0 | 0 | - | - | - | - | - | - | - |
Acquisition of a business | ||||||||||
- | - | - | - | 1,050,011 | - | 52,725 | 26,435 | - | - | - |
Acquisition of in-process research and development | ||||||||||
- | - | - | - | 25,000 | - | - | - | - | - | - |
Proceeds from disposal of property and equipment | ||||||||||
0 | 145 | 280 | 0 | - | - | - | - | - | - | - |
Acquisition of patents | ||||||||||
- | - | - | - | - | - | 150 | - | - | - | - |
Purchases of marketable securities | ||||||||||
12,065 | 0 | 8,277 | 68,818 | 116,209 | 73,754 | 37,746 | 38,462 | 195,162 | 71,325 | 144,567 |
Proceeds from sale of other assets | ||||||||||
0 | 80 | 66,557 | 115,207 | - | - | - | - | - | - | - |
Maturities of marketable securities | ||||||||||
4,209 | 0 | 0 | - | 84,884 | 27,046 | 53,056 | 61,405 | 58,495 | 64,531 | 96,396 |
Sales of marketable securities | ||||||||||
7,856 | 1,200 | 0 | 2,007 | - | - | 1,341 | 43,704 | 75,177 | 7,485 | 52,926 |
Proceeds from sale of future royalties and milestones to PDL | ||||||||||
- | - | - | - | - | - | 240,500 | - | - | - | - |
Principal payments on long-term debt | ||||||||||
- | - | - | - | - | - | - | - | 2,244 | 3,843 | 3,312 |
Net cash provided by (used in) investing activities | ||||||||||
-1,481 | -7,082 | 57,894 | 45,536 | -1,108,051 | -47,307 | -38,036 | 33,332 | -62,188 | 512 | 4,126 |
Financing Activities | ||||||||||
Proceeds from issuance of Convertible debt | ||||||||||
- | - | - | - | - | 345,000 | - | - | - | - | - |
Convertible debt issuance costs | ||||||||||
- | - | - | - | - | 10,775 | - | - | - | - | - |
Proceeds from issuance of Senior Notes | ||||||||||
- | - | - | - | 562,063 | - | - | - | - | - | - |
Payment of contingent consideration liability | ||||||||||
0 | 184 | 1,673 | 1,783 | 1,041 | - | - | - | - | - | - |
Senior Notes issuance costs | ||||||||||
- | - | - | - | 511 | - | - | - | - | - | - |
Repayment of Senior Notes | ||||||||||
120,000 | 82,500 | 110,000 | 100,000 | - | - | - | - | - | - | - |
Payment for Debt Extinguishment or Debt Prepayment Cost | ||||||||||
30,000 | 0 | 7,400 | 5,000 | - | - | - | - | - | - | - |
Fees for modification of Senior Notes | ||||||||||
3,249 | 0 | 0 | - | - | - | - | - | - | - | - |
Excess tax benefit from stock-based compensation | ||||||||||
- | - | - | - | - | 3,190 | -347 | - | - | - | - |
Convertible notes issuance costs | ||||||||||
4,268 | 0 | 0 | - | - | - | - | - | - | - | - |
Proceeds from issuance of common stock | ||||||||||
251 | 2,020 | 8,940 | 9,951 | 10,398 | 9,803 | 3,727 | 2,686 | 8,298 | 1,417 | 2,042 |
Shares withheld for payment of employee's withholding tax liability | ||||||||||
570 | 686 | 753 | 3,342 | 2,812 | - | - | - | - | - | - |
Net cash used in financing activities | ||||||||||
-157,836 | -81,350 | -110,886 | -100,174 | 568,097 | 347,218 | 243,880 | 2,686 | 6,054 | -2,426 | -1,270 |
Net increase (decrease) in cash and cash equivalents | ||||||||||
-68,842 | -15,935 | 9,175 | 16,625 | -387,584 | 243,994 | 215,598 | 5,033 | 1,517 | -4,295 | 4,694 |
Supplemental Disclosure of Cash Flow Information | ||||||||||
Net cash paid for income taxes | ||||||||||
4,401 | 6,472 | 121 | - | -4,048 | 58,318 | 45 | 144 | - | - | -6 |
Net cash received for income taxes | ||||||||||
- | - | - | 14,425 | - | - | - | - | 421 | 5 | - |
Cash paid for interest | ||||||||||
37,788 | 48,440 | 55,542 | 71,093 | 39,511 | - | - | - | 133 | 512 | 935 |
Non-cash consideration for in-process research and development | ||||||||||
0 | 0 | 19,900 | 0 | 29,900 | - | - | - | - | - | - |
Accrued research and development | ||||||||||
0 | 0 | 5,000 | 0 | - | - | - | - | - | - | - |
Capital expenditures incurred but not yet paid | ||||||||||
500 | 212 | 0 | 402 | - | - | - | - | - | - | - |