| Dec'19 | Dec'18 | Dec'17 | Dec'16 | Dec'15 | Dec'14 | Dec'13 | Dec'12 | Dec'11 | Dec'10 | Dec'09 |
|---|---|---|---|---|---|---|---|---|---|---|
Cash flows from operating activities: | ||||||||||
Net loss | ||||||||||
-33,226 | -95,304 | 68,271 | -41,276 | 41,798 | -85,469 | -42,925 | -3,228 | -8,774 | -8,975 | -11,439 |
Adjustments to reconcile net loss to net cash provided by operating activities: | ||||||||||
Depreciation and amortization | ||||||||||
2,486 | 7,430 | 4,883 | 14,489 | 13,132 | 14,141 | 3,062 | - | - | - | - |
Impairment of intangible asset | ||||||||||
0 | 66,087 | 0 | 0 | - | - | - | - | - | - | - |
Loss on disposal of property and equipment | ||||||||||
- | - | - | - | 0 | 4,952 | -14 | 37 | 11 | 68 | 0 |
Amortization of premiums on marketable securities | ||||||||||
-41 | -2,823 | -732 | -918 | -779 | 0 | 0 | - | - | - | - |
Remeasurement of acquisition liabilities and royalty agreements (Note 21) | ||||||||||
- | - | - | - | - | - | - | 18,834 | 0 | - | - |
Interest expenses on debt related to the royalty agreement including related party | ||||||||||
- | - | - | - | - | - | - | 0 | - | - | - |
Foreign exchange loss (gain) | ||||||||||
- | - | - | - | 8,969 | 6,252 | 0 | - | - | - | - |
Grants recognized in research and development expenses | ||||||||||
- | - | - | - | 1,498 | - | - | - | - | - | - |
Depreciation of property and equipment and intangible assets | ||||||||||
- | - | - | - | - | - | - | 3,183 | 3,346 | 4,696 | 5,917 |
Unrealized exchange gain | ||||||||||
- | - | - | - | - | - | - | 0 | - | - | - |
Gains on sales of marketable securities | ||||||||||
- | - | - | - | - | - | - | 6 | 41 | 74 | 153 |
Grants recognized in research and development expenses | ||||||||||
- | - | - | - | - | 589 | 676 | 975 | 3,227 | 884 | 2,522 |
Remeasurement of acquisition-related contingent consideration | ||||||||||
845 | -22,731 | -31,040 | 49,285 | 30,957 | 60,503 | 28,135 | - | - | - | - |
Remeasurement of financing-related contingent consideration | ||||||||||
378 | -1,899 | -2,071 | 6,548 | 4,883 | 3,319 | 1,990 | - | - | - | - |
Amortization of debt discount and debt issuance costs | ||||||||||
5,995 | 4,830 | 0 | 0 | - | - | - | - | - | - | - |
Changes in deferred tax | ||||||||||
6,334 | 19,152 | -3,556 | 4,000 | -69 | 2,113 | - | - | - | - | - |
Interest expense on debt related to the royalty agreements (Note 25) | ||||||||||
- | - | - | - | - | - | - | - | 0 | - | - |
Remeasurement of acquisition liabilities | ||||||||||
- | - | - | - | - | - | - | - | - | 0 | - |
Impairment of assets (Note 13) | ||||||||||
- | - | - | - | - | - | - | 7,170 | 0 | 0 | - |
Imputed interest on long-term debt | ||||||||||
- | - | - | - | - | - | 712 | 0 | - | - | - |
Change in deferred tax and income tax deferred charge | ||||||||||
- | - | - | - | - | - | -11,320 | -4,758 | 0 | 0 | - |
Stock-based compensation expense | ||||||||||
519 | 7,852 | 8,072 | 14,679 | 7,741 | 2,690 | 2,029 | 3,040 | 2,779 | 3,170 | 5,499 |
Loss on deconsolidation of subsidiary | ||||||||||
-1,750 | 0 | 0 | - | - | - | - | - | - | - | - |
Other adjustments | ||||||||||
-295 | 1,365 | -968 | -331 | - | - | - | - | - | - | - |
Net changes in assets and liabilities | ||||||||||
Accounts receivable | ||||||||||
-2,471 | -3,452 | -3,054 | 10,050 | 8,440 | -3,249 | 511 | -2,610 | 464 | -733 | 1,257 |
Inventories | ||||||||||
-1,155 | -711 | 2,899 | -1,831 | -3,036 | 3,112 | 2,186 | -176 | 917 | -152 | -909 |
Prepaid expenses and other current assets | ||||||||||
1,187 | -3,577 | 3,741 | -3,412 | 684 | 2,329 | -315 | -800 | -856 | -964 | 1,722 |
Research and development tax credit receivable | ||||||||||
1,014 | 2,545 | 3,141 | -397 | -2,975 | -13,210 | -665 | 6,642 | 3,938 | -837 | -4,064 |
Accounts payable & other current liabilities | ||||||||||
4,641 | -2,032 | 595 | -434 | -8,533 | 7,219 | 800 | -613 | -825 | -450 | 32 |
Deferred revenue | ||||||||||
-114 | -1,892 | -216 | -2,923 | - | - | - | - | - | - | - |
Deferred revenue | ||||||||||
- | - | - | - | 3,815 | -55 | -14 | -4,984 | 856 | -3,358 | 8,251 |
Accrued expenses | ||||||||||
357 | -10,640 | 13,187 | 6,764 | 3,376 | 452 | 1,211 | -742 | -491 | -723 | 453 |
Accrued income taxes | ||||||||||
-30 | -341 | -786 | 1,778 | -393 | 70 | - | - | - | - | - |
Earn-out payments for contingent consideration in excess of acquisition-date fair value | ||||||||||
10,988 | 19,468 | 31,636 | 20,252 | 0 | 0 | - | - | - | - | - |
Royalty payments for contingent consideration payable in excess of original fair value | ||||||||||
1,748 | 2,838 | 4,429 | 2,469 | 0 | 0 | - | - | - | - | - |
Other current liabilities | ||||||||||
- | - | - | - | - | - | - | -682 | 399 | -814 | -2,251 |
Other assets and liabilities | ||||||||||
4,027 | 2,001 | 4,761 | -535 | -249 | 10,599 | 1,977 | -1,383 | -129 | 663 | 2,088 |
Net cash used in operating activities | ||||||||||
-38,325 | -82,716 | 16,662 | 18,901 | 84,293 | -10,617 | -20,676 | -23,139 | -10,323 | -5,457 | 8,195 |
Purchases of property and equipment | ||||||||||
29 | 178 | 591 | 1,201 | 1,629 | 1,728 | 1,029 | 1,069 | 1,903 | 3,599 | 1,770 |
Proceeds from disposal of property and equipment | ||||||||||
154 | 0 | 0 | - | - | 13,242 | 1,007 | 67 | 185 | 131 | 0 |
Acquisitions of businesses, including cash acquired and other adjustments | ||||||||||
- | - | - | 628 | 0 | 0 | - | 1,771 | - | 0 | - |
Purchase of intangible assets | ||||||||||
0 | 20,000 | 53,111 | 0 | 0 | - | - | - | - | - | - |
Proceeds from sales of marketable securities | ||||||||||
63,246 | 359,507 | 189,009 | 71,546 | - | - | - | - | - | - | - |
Proceeds from sales of marketable securities | ||||||||||
- | - | - | - | 48,308 | 24,993 | 7,152 | 18,246 | 26,382 | 83,128 | 138,476 |
Purchases of marketable securities | ||||||||||
24,648 | 376,310 | 151,005 | 107,603 | 78,409 | 79,590 | 1,085 | 3,567 | 25,015 | 73,632 | 160,968 |
Net cash provided by investing activities | ||||||||||
38,723 | -36,981 | -15,698 | -36,630 | -31,730 | -43,083 | 6,045 | 15,448 | -351 | 6,028 | -24,262 |
Cash flows from financing activities: | ||||||||||
Proceeds from Issuance of Long-term Debt | ||||||||||
0 | 143,750 | 0 | 0 | - | - | 19,333 | 6,668 | 7,855 | 436 | 2,191 |
Payments for debt issuance costs | ||||||||||
0 | 6,190 | 0 | 0 | 747 | 355 | 475 | 0 | - | - | - |
Principal payments on capital lease obligations | ||||||||||
- | - | - | - | - | 161 | 77 | 97 | 96 | 35 | 67 |
Earn-out payments for related party contingent consideration | ||||||||||
0 | 645 | 1,246 | 6,892 | 24,526 | 1,357 | 907 | 0 | 0 | - | - |
Royalty payments for related party payable | ||||||||||
- | - | - | 1,225 | 3,371 | 206 | 0 | - | - | - | - |
Exercise of warrants | ||||||||||
0 | 2,911 | 0 | 0 | 2,814 | 0 | 0 | - | - | - | - |
Proceeds from issuance of ordinary shares | ||||||||||
118 | 577 | 404 | 440 | 6,990 | 132,260 | 400 | 607 | 296 | 704 | 291 |
Reimbursement of loans | ||||||||||
- | - | - | - | 4,911 | 34,186 | 0 | - | - | - | - |
Payments for debt issuance costs | ||||||||||
- | - | - | - | - | - | - | 223 | 1,910 | 1,879 | 3,999 |
Share repurchases | ||||||||||
0 | 27,637 | 22,361 | 0 | 0 | - | - | - | - | - | - |
Other financing activities, net | ||||||||||
-145 | -107 | -115 | -277 | - | - | - | - | - | - | - |
Net cash provided by financing activities | ||||||||||
-27 | 112,659 | -23,318 | -7,954 | -23,751 | 95,995 | 18,274 | 6,955 | 6,145 | -774 | -1,584 |
Effect of foreign currency exchange rate changes on cash and cash equivalents | ||||||||||
78 | -201 | -297 | - | - | - | - | - | - | - | - |
Effect of foreign currency exchange rate changes on cash and cash equivalents | ||||||||||
- | - | - | -166 | -3,508 | -9,171 | 251 | 22 | -199 | -329 | -654 |
Net change in cash and cash equivalents | ||||||||||
449 | -7,239 | -22,651 | - | - | - | - | - | - | - | - |
Net change in cash and cash equivalents | ||||||||||
- | - | - | -25,849 | 25,304 | 33,124 | 3,894 | -714 | -4,728 | -532 | -18,305 |
Supplemental disclosures of cash flow information: | ||||||||||
Interest paid | ||||||||||
6,469 | 3,359 | 1,050 | 788 | - | - | - | - | - | - | - |
Interest paid | ||||||||||
- | - | - | - | 4,738 | 4,431 | 1,701 | 118 | 73 | 24 | 100 |
Income taxes paid | ||||||||||
140 | 776 | 19,143 | 27,180 | 42,121 | 403 | 153 | 56 | 0 | 0 | 0 |
Income tax paid Grants recognized in research and development expenses and operating income | ||||||||||
- | - | - | - | - | - | 0 | - | - | - | - |
Capital lease obligations incurred | ||||||||||
- | - | - | - | - | - | - | 0 | 220 | 131 | 0 |
Fair value of assets acquired at acquisition date: | ||||||||||
- | - | - | - | - | - | - | 50,927 | 0 | 0 | - |
Liabilities assumed at acquisition date: | ||||||||||
- | - | - | - | - | - | - | 50,927 | 0 | 0 | - |