| Dec'19 | Dec'18 | Dec'17 | Dec'16 | Dec'15 | Dec'14 | Dec'13 | Dec'12 | Dec'11 | Dec'10 | Dec'09 |
|---|---|---|---|---|---|---|---|---|---|---|
Revenues: | ||||||||||
Revenues | ||||||||||
28,795 | 5,409 | 7,579 | 2,515 | - | - | - | - | - | - | - |
Revenues | ||||||||||
- | - | - | - | 19,024 | 18,123 | 1,293 | 19,286 | 164,849 | 44,682 | 20,719 |
Operating expenses: | ||||||||||
Research and development | ||||||||||
17,958 | 20,652 | 25,179 | 23,703 | 12,875 | 38,254 | 68,468 | 91,358 | 101,735 | 86,345 | 51,792 |
General and administrative | ||||||||||
11,211 | 10,781 | 9,138 | 8,205 | 10,217 | 18,589 | 28,712 | 36,932 | 29,167 | 14,763 | 10,120 |
Settlement costs (Note 13) | ||||||||||
- | -667 | 2,073 | - | 4,000 | - | - | - | - | - | - |
Restructuring and lease exit | ||||||||||
- | - | - | - | 4,358 | 11,729 | 8,017 | 2,633 | - | - | - |
Operating expenses, total | ||||||||||
29,169 | 30,766 | 36,390 | 31,908 | 31,450 | 68,572 | 105,197 | 130,923 | 130,902 | 101,108 | 61,912 |
Loss from operations | ||||||||||
-374 | -25,357 | -28,811 | -29,393 | -12,426 | -50,449 | -103,904 | -111,637 | 33,947 | -56,426 | -41,193 |
Other income, net: | ||||||||||
Interest expense, net | ||||||||||
1,815 | 2,191 | 2,373 | 1,949 | 2,286 | 2,356 | 3,127 | 3,501 | 3,836 | 3,389 | 2,811 |
Change in fair value of PIPE Warrant liability | ||||||||||
-11,577 | -19,919 | 33,740 | -4,751 | - | - | - | - | - | - | - |
Other income | ||||||||||
- | 2,300 | - | -195 | -289 | 66 | -123 | 247 | 10 | 900 | -333 |
Interest income | ||||||||||
- | - | - | - | - | - | 125 | 497 | 527 | 126 | 144 |
Other income, net | ||||||||||
9,762 | 20,028 | -36,113 | 2,607 | -2,575 | -2,290 | -3,125 | -2,757 | -3,299 | -2,363 | -3,000 |
Net income (loss) before provision for income taxes | ||||||||||
9,388 | -5,329 | -64,924 | -26,786 | -15,001 | -52,739 | - | - | - | - | -44,193 |
Provision for income taxes | ||||||||||
0 | 0 | 101 | 101 | - | - | - | - | - | - | -100 |
Net income (loss) | ||||||||||
9,388 | -5,329 | -65,025 | -26,887 | -15,001 | -52,739 | -107,029 | -114,394 | 30,648 | -58,789 | -44,093 |
Net loss per share - basic and diluted | ||||||||||
- | - | - | - | -0.27 | -1.01 | -2.10 | -2.64 | - | - | - |
Weighted average number of common shares outstanding basic and diluted | ||||||||||
- | - | - | - | 55,701 | 52,289 | 50,928 | 43,374 | - | - | - |
Basic net income (loss) per share | ||||||||||
Net income (loss) per share | ||||||||||
0.61 | -0.44 | -6.14 | -0.39 | - | - | - | - | 0.77 | -2.30 | -27.43 |
Weighted average number of common shares outstanding | ||||||||||
15,331 | 12,059 | 10,593 | 69,268 | - | - | - | - | 39,715 | 25,582 | 1,607 |
Diluted net income (loss) per share | ||||||||||
Net income (loss) per share | ||||||||||
0.61 | -1.93 | -6.14 | -0.39 | - | - | - | - | 0.74 | -2.30 | -27.43 |
Weighted average number of common shares and dilutive common share equivalents outstanding | ||||||||||
15,376 | 13,073 | 10,593 | 69,268 | - | - | - | - | 41,473 | 25,582 | 1,607 |
Collaboration and Licensing Revenue | ||||||||||
Revenues | ||||||||||
27,934 | 4,947 | 7,560 | 2,515 | - | - | - | - | - | - | - |
Partnership Royalties | ||||||||||
Revenues | ||||||||||
861 | 462 | 19 | - | - | - | - | - | - | - | - |