| Dec'19 | Dec'18 | Dec'17 | Dec'16 | Dec'15 | Dec'14 | |
|---|---|---|---|---|---|---|
Operating expenses: | ||||||
Research and development | ||||||
53,647 | 23,495 | 19,957 | 21,199 | 6,776 | 4,279 | |
General and administrative | ||||||
13,598 | 9,351 | 7,206 | 6,343 | 2,419 | 1,392 | |
Total operating expenses | ||||||
67,245 | 32,846 | 27,164 | 27,543 | 9,196 | 5,672 | |
Loss from operations | ||||||
-67,245 | -32,846 | -27,164 | -27,543 | -9,196 | -5,672 | |
Interest and amortization of debt discount (expense) | ||||||
-1,239 | -1,127 | -1,340 | -132 | -736 | 2,233 | |
Tax credit | ||||||
139 | 217 | 207 | 474 | - | 184 | |
Change in fair value of warrant liabilities | ||||||
- | -2,791 | 646 | - | 108 | 57 | |
Change in fair value of embedded derivative liabilities | ||||||
- | - | - | - | 274 | 182 | |
Loss on extinguishment of debt | ||||||
- | - | - | - | -2,444 | -2,870 | |
Net loss | ||||||
-68,345 | -30,965 | -28,943 | -27,201 | -12,210 | -6,000 | |
Net loss per common share, basic and diluted | ||||||
-2.01 | -1.15 | -1.27 | -1.42 | -1.02 | -0.66 | |
Weighted average common shares outstanding, basic and diluted | ||||||
34,020 | 26,883 | 22,764 | 19,150 | 11,945 | 9,099 | |