| Dec'19 | Dec'18 | Dec'17 | Dec'16 | Dec'15 | Dec'14 | Dec'13 | Dec'12 | Dec'11 | Dec'10 | Dec'09 |
|---|---|---|---|---|---|---|---|---|---|---|
Operating activities | ||||||||||
Net loss | ||||||||||
-108,897 | -101,252 | -65,782 | -55,144 | -43,019 | -45,189 | -30,108 | -39,081 | -56,948 | -33,853 | -13,451 |
Adjustments to reconcile net loss to net cash used in operating activities: | ||||||||||
Depreciation and amortization | ||||||||||
724 | 770 | 704 | 483 | 180 | 177 | 304 | 628 | 886 | 2,267 | 1,613 |
Loss (gain) on disposal of property and equipment | ||||||||||
- | -7 | 12 | -17 | 0 | -27 | 47 | - | - | - | - |
Stock-based compensation expense | ||||||||||
17,719 | 9,396 | 12,621 | 8,487 | 9,705 | 10,177 | 4,368 | 4,167 | 4,772 | 6,302 | 5,525 |
Amortization of debt issuance costs | ||||||||||
1,278 | 885 | 876 | 558 | 439 | 439 | 439 | 439 | 356 | - | - |
Amortization of premium/discount on investments | ||||||||||
117 | 110 | 157 | 523 | 570 | 150 | - | - | - | - | - |
Change in fair value of foreign currency derivative | ||||||||||
-347 | -1,049 | -966 | 811 | -564 | 5,487 | 5,294 | -749 | -4,000 | - | - |
Deferred revenue | ||||||||||
1,899 | -7,079 | -1,722 | -1,631 | 1,199 | 4,429 | -1,103 | -9,577 | -1,552 | -2,497 | -2,565 |
Changes in operating assets and liabilities: | ||||||||||
Receivables | ||||||||||
17,853 | -1,824 | -2,651 | 2,525 | -3,247 | 7,375 | -2,447 | -1,269 | -24,396 | -3,495 | 21,740 |
Inventory | ||||||||||
-1,649 | 1,649 | -500 | -1,112 | 929 | 683 | 0 | -263 | -635 | -5,383 | 6,281 |
Prepaid expenses and other assets | ||||||||||
1,364 | 866 | -951 | -3,702 | -637 | 2,093 | 620 | 623 | -626 | -51 | -81 |
Deferred collaboration expense | ||||||||||
- | - | - | -71 | 102 | -59 | -5,133 | -2,301 | -1,309 | 220 | -377 |
Accounts payable and accrued expenses | ||||||||||
11,741 | 4,487 | 3,842 | -10,524 | 13,676 | 4,656 | -2,049 | 2,068 | -10,731 | -9,483 | 20,223 |
Interest payable | ||||||||||
3,056 | -247 | 3,105 | 2,244 | 717 | 2,162 | - | - | - | - | - |
Net cash used in operating activities | ||||||||||
-89,584 | -92,565 | -41,143 | -53,438 | -13,116 | -38,551 | -26,530 | -37,397 | -32,251 | -28,555 | -16,218 |
Investing activities | ||||||||||
Acquisition of property and equipment | ||||||||||
343 | 366 | 328 | 5,277 | 5,122 | 106 | 30 | 113 | 55 | 325 | 604 |
Proceeds from sale of property and equipment | ||||||||||
- | - | 12 | 4 | 0 | 0 | 50 | - | - | - | - |
Change in restricted cash | ||||||||||
- | - | - | - | 1,462 | -1 | -157 | -317 | - | - | 625 |
Purchases of investments | ||||||||||
3,018 | 62,614 | 107,787 | 14,106 | 53,830 | 73,875 | 23,974 | 16,153 | 45,500 | 55,909 | 54,103 |
Sales and maturities of investments | ||||||||||
81,295 | 67,748 | 43,461 | 42,652 | 42,410 | 34,000 | 20,330 | 40,833 | 56,873 | 56,455 | 42,437 |
Net cash provided by investing activities | ||||||||||
77,934 | 4,768 | -64,642 | 23,273 | -18,004 | -39,980 | -3,467 | 24,884 | 11,318 | 221 | -12,895 |
Financing activities | ||||||||||
Proceeds from senior credit facility | ||||||||||
19,477 | 10,353 | - | 22,658 | 0 | 0 | - | - | - | - | - |
Sale of common stock, net | ||||||||||
58,500 | 53,400 | 134,000 | - | 0 | 106,600 | 23,633 | 17,805 | 1,027 | - | 45,740 |
Sale of pre-funded warrants | ||||||||||
19,882 | - | - | - | - | - | - | - | - | - | - |
Net proceeds from common stock issued under stock-based compensation plans | ||||||||||
1,239 | 2,852 | 1,581 | 317 | 5,479 | 5,307 | 1,333 | 534 | 278 | 553 | 2,117 |
Payment of senior credit facility | ||||||||||
- | 4,025 | - | - | - | - | - | - | - | - | - |
(Decrease) increase in lease financing obligation | ||||||||||
- | -76 | 122 | 329 | 0 | 0 | 124 | 321 | 300 | 283 | 194 |
Receipt of foreign currency derivative collateral | ||||||||||
- | - | - | - | - | - | 5,180 | -1,700 | -3,480 | - | - |
Purchases of treasury stock | ||||||||||
- | - | - | - | - | - | - | - | 61 | 5 | 155 |
Issuance of non-recourse notes payable, net | ||||||||||
- | - | - | - | - | - | - | - | 25,691 | - | - |
Net cash provided by financing activities | ||||||||||
99,098 | 62,504 | 135,703 | 23,304 | 5,479 | 111,907 | 30,270 | 16,960 | 23,755 | 831 | 47,896 |
Increase (decrease) in cash, cash equivalents and restricted cash | ||||||||||
87,448 | -25,293 | 29,918 | -6,861 | -25,641 | 33,376 | 273 | 4,447 | 2,822 | -27,503 | 18,783 |