| Dec'19 | Dec'18 | Dec'17 | Dec'16 | Dec'15 | Dec'14 | Dec'13 | Dec'12 | Dec'11 | Dec'10 | Dec'09 |
|---|---|---|---|---|---|---|---|---|---|---|
Revenues: | ||||||||||
Revenues | ||||||||||
48,835 | 20,653 | 25,186 | 26,353 | 48,257 | 13,608 | 17,331 | 26,293 | 19,643 | 62,381 | 74,590 |
Expenses | ||||||||||
Cost of product sales | ||||||||||
3,726 | - | 1,142 | 2,297 | 1,368 | 1 | 0 | - | - | 86 | 4,544 |
Research and development | ||||||||||
107,068 | 84,888 | 66,962 | 61,008 | 72,758 | 51,796 | 41,943 | 49,160 | 57,249 | 83,900 | 73,661 |
Selling, general and administrative | ||||||||||
37,121 | 29,514 | 13,933 | 11,253 | 13,047 | 7,461 | 6,007 | 9,130 | 11,981 | 11,718 | 10,122 |
Royalty | ||||||||||
375 | 471 | 560 | 402 | 528 | 121 | 98 | 132 | - | - | - |
Restructuring | ||||||||||
- | - | - | - | - | - | - | 1,759 | - | 1,034 | - |
Total operating expenses | ||||||||||
148,290 | 114,873 | 82,597 | 74,960 | 87,701 | 59,379 | 48,048 | 60,181 | 69,230 | 96,738 | 88,327 |
Loss from operations | ||||||||||
-99,455 | -94,220 | -57,411 | -48,607 | -39,444 | -45,771 | -30,717 | -33,888 | -49,587 | -34,357 | -13,737 |
Interest and other income | ||||||||||
1,933 | 2,252 | 1,015 | 793 | 535 | 93 | 93 | 222 | 413 | 504 | 286 |
Interest expense | ||||||||||
11,892 | 9,176 | 8,565 | 6,487 | 5,200 | 4,998 | 4,778 | 4,666 | 3,774 | - | - |
(Loss) gain on foreign currency derivative | ||||||||||
517 | -108 | -821 | -843 | 1,090 | 5,487 | 5,294 | -749 | -4,000 | - | - |
Net loss | ||||||||||
-108,897 | -101,252 | -65,782 | -55,144 | -43,019 | -45,189 | -30,108 | -39,081 | -56,948 | -33,853 | -13,451 |
Weighted average shares outstanding (in Shares) | ||||||||||
- | - | - | - | - | - | - | 49,474 | 45,144 | 44,564 | - |
Unrealized (loss) gain on available for sale investments | ||||||||||
336 | -54 | -231 | 194 | -76 | -134 | -23 | -13 | -65 | 131 | - |
Net comprehensive loss | ||||||||||
-108,561 | -101,306 | -66,013 | -54,950 | -43,095 | -45,323 | -30,131 | -39,094 | -57,013 | -33,722 | - |
Basic and diluted net loss per common share (in dollars per share) | ||||||||||
-0.94 | -0.98 | -0.78 | -0.75 | -0.59 | -0.68 | -0.55 | -0.79 | -1.26 | -0.76 | -0.35 |
Weighted average shares outstanding (in shares) | ||||||||||
115,600 | 103,185 | 84,451 | 73,699 | 72,901 | 66,773 | 55,216 | - | - | - | - |
Product [Member] | ||||||||||
Revenues | ||||||||||
17,533 | - | 1,501 | 2,269 | 6,291 | 33 | 0 | - | - | 325 | 22,923 |
Royalty [Member] | ||||||||||
Revenues | ||||||||||
6,303 | 6,101 | 10,543 | 9,682 | 2,386 | 3,025 | 2,562 | 3,317 | 0 | - | - |
Collaborative and Other Research and Development [Member] | ||||||||||
Revenues | ||||||||||
24,999 | 14,552 | 13,142 | 14,402 | 39,580 | 10,550 | 14,769 | 22,976 | 19,643 | 62,056 | 51,667 |