| Mar'20 | Dec'19 | Sep'19 | Jun'19 | Mar'19 | Dec'18 | Sep'18 | Jun'18 | Mar'18 | Dec'17 | Sep'17 | Jun'17 | Mar'17 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
Cash flows from operating activities: | ||||||||||||
Net loss | ||||||||||||
-172,937 | -149,264 | -106,167 | -211,070 | -62,304 | -54,750 | -61,441 | -39,269 | -85,462 | -27,082 | -42,915 | -38,440 | -18,753 |
Adjustments to reconcile net loss to net cash used in operating activities: | ||||||||||||
Non-cash share-based compensation expense | ||||||||||||
16,879 | 20,117 | 9,971 | 17,554 | 7,330 | 4,487 | 3,742 | 5,608 | 3,088 | 2,434 | 6,256 | 2,663 | 1,886 |
Non-cash interest expense on mandatorily redeemable preferred shares | ||||||||||||
5,561 | 4,378 | 4,378 | 3,955 | 0 | - | - | - | - | - | - | - | - |
Non-cash interest expense on liability related to sale of future royalties | ||||||||||||
8,425 | 7,308 | 7,308 | 5,147 | 6,817 | 5,592 | 5,633 | 501 | 0 | - | - | - | - |
Non-cash interest expense | ||||||||||||
- | - | - | - | - | - | - | - | - | 0 | 215 | 289 | 280 |
Change in fair value of derivative liability | ||||||||||||
5,781 | 895 | 1,717 | 1,263 | 0 | - | - | - | - | 0 | 0 | -223 | -289 |
Change in fair value of warrant liability | ||||||||||||
- | - | - | - | - | 0 | 0 | 0 | 1,182 | -2,268 | 2,426 | 2,629 | 454 |
Change in fair value of contingent equity liability | ||||||||||||
- | - | - | - | - | - | - | - | - | 0 | 0 | 9,707 | 3,375 |
Loss from equity method investment | ||||||||||||
-1,380 | -1,768 | -1,993 | -1,415 | -900 | -742 | -697 | -641 | -728 | -681 | -638 | -348 | -218 |
Other non-cash items | ||||||||||||
-476 | -209 | -166 | -138 | -133 | -178 | -38 | -36 | -17 | -14 | -34 | -20 | 4 |
Changes in operating assets and liabilities: | ||||||||||||
Trade receivables, net | ||||||||||||
4,337 | - | - | - | 0 | - | - | - | - | - | - | - | - |
Inventories | ||||||||||||
3,609 | - | - | - | 0 | - | - | - | - | - | - | - | - |
Prepaid expenses and other current assets | ||||||||||||
25,733 | 4,958 | -2,017 | -1,353 | 1,876 | -6,705 | 4,645 | -317 | 5,270 | 1,448 | -554 | 3,356 | 480 |
Other assets | ||||||||||||
-20 | -108 | 327 | -16 | 29 | -53 | 21 | 11 | 0 | - | - | - | - |
Accounts payable | ||||||||||||
14,475 | 2,509 | -1,307 | 4,659 | -2,542 | 5,453 | 631 | -4,918 | 4,224 | -4,003 | 4,707 | 615 | 2,656 |
Accrued expenses and other current liabilities | ||||||||||||
2,860 | 16,458 | 4,477 | 15,684 | 6,701 | -1,824 | 1,878 | 3,670 | -27 | -9,030 | 6,674 | 706 | 2,991 |
Other long-term liabilities | ||||||||||||
37 | 25 | 0 | -1 | -1,999 | -52 | 672 | -31 | -13 | -33 | 56 | 0 | 6 |
Net cash used in operating activities | ||||||||||||
-150,722 | -100,447 | -70,128 | -159,887 | -46,869 | -33,416 | -48,736 | -33,456 | -81,533 | -40,767 | -21,346 | -25,050 | -7,652 |
Purchases of property and equipment | ||||||||||||
1,016 | 897 | 189 | 410 | 1,038 | 1,531 | 1,133 | 1,144 | 357 | 288 | 204 | 28 | 21 |
Purchase of equity method investment | ||||||||||||
- | - | - | - | - | 5,000 | 0 | 0 | 1,375 | 3,628 | 0 | 1,375 | 1,624 |
Payments for leasehold improvements | ||||||||||||
1,600 | - | - | - | 0 | - | - | - | - | - | - | - | - |
Payments for intangible assets | ||||||||||||
20,750 | - | - | - | 0 | - | - | - | - | - | - | - | - |
Net cash used in investing activities | ||||||||||||
-23,366 | -2,147 | -189 | -410 | -1,038 | -6,531 | -1,133 | -1,144 | -1,732 | -3,916 | -204 | -1,403 | -1,645 |
Proceeds from issuance of common shares | ||||||||||||
283,333 | 0 | 21,221 | 282,000 | 0 | 135,125 | 0 | 0 | 55,000 | - | - | - | - |
Payments of issuance costs | ||||||||||||
340 | 0 | 633 | 517 | 0 | - | - | - | - | 29 | 1,986 | 1,004 | 2,049 |
Proceeds from issuance of Series A preferred shares | ||||||||||||
- | - | - | - | - | - | - | - | - | - | 0 | 0 | 40,000 |
Proceeds from exercise of stock options | ||||||||||||
2,607 | 2,747 | 1,564 | 148 | 1,065 | 886 | 602 | 833 | 1,003 | - | - | - | - |
Net cash provided by financing activities | ||||||||||||
285,600 | 2,747 | 22,152 | 408,629 | 1,065 | 136,011 | 602 | 147,846 | 56,003 | 397 | -6,986 | 178,397 | 37,951 |
Net increase in cash and restricted cash | ||||||||||||
111,512 | -99,847 | -48,165 | 248,332 | -46,842 | 96,064 | -49,267 | 113,246 | -27,262 | -44,286 | -28,536 | 151,944 | 28,654 |
Supplemental disclosure of cash flow information: | ||||||||||||
Cash paid for interest | ||||||||||||
0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 24 | 73 | 25 |
Cash paid for income taxes | ||||||||||||
0 | -12 | 407 | 20 | 408 | 60 | 250 | -57 | 80 | - | - | - | - |
Supplemental disclosure of non-cash investing and financing activities: | ||||||||||||
Deferred offering costs included in accounts payable | ||||||||||||
160 | - | -633 | 633 | 0 | - | 0 | -2,610 | 2,987 | - | -1,986 | 500 | 1,515 |
Intangible asset costs included in accounts payable | ||||||||||||
20,750 | - | - | - | 0 | - | - | - | - | - | - | - | - |
Deferred offering costs included in accounts payable and accrued expenses | ||||||||||||
- | - | - | - | - | - | - | - | - | - | - | - | 65 |
Beneficial conversion feature on Series A preferred shares | ||||||||||||
- | - | - | - | - | - | - | - | - | 0 | 0 | 0 | -12,006 |
Accretion of beneficial conversion feature on Series A preferred shares | ||||||||||||
- | - | - | - | - | - | - | - | - | 0 | 0 | 8,006 | 4,000 |
Issuance of Series A preferred shares as payment of offering costs | ||||||||||||
- | - | - | - | - | - | - | - | - | 0 | 0 | 0 | 1,242 |
Issuance of common shares as payment of equity investment | ||||||||||||
- | - | - | - | - | - | - | - | - | 0 | 0 | 0 | 352 |