| Mar'20 | Dec'19 | Sep'19 | Jun'19 | Mar'19 | Dec'18 | Sep'18 | Jun'18 | Mar'18 | Dec'17 | Sep'17 | Jun'17 | Mar'17 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
Cash flows from operating activities: | ||||||||||||
Net loss | ||||||||||||
-639,438 | -528,805 | -434,291 | -389,565 | -217,764 | -240,922 | -213,254 | -194,728 | -193,899 | -127,190 | 0 | 0 | 0 |
Adjustments to reconcile net loss to net cash used in operating activities: | ||||||||||||
Non-cash share-based compensation expense | ||||||||||||
64,521 | 54,972 | 39,342 | 33,113 | 21,167 | 16,925 | 14,872 | 17,386 | 14,441 | 13,239 | 0 | 0 | 0 |
Non-cash interest expense on mandatorily redeemable preferred shares | ||||||||||||
18,272 | 12,711 | 0 | 0 | 0 | - | - | - | - | - | - | - | - |
Non-cash interest expense on liability related to sale of future royalties | ||||||||||||
28,188 | 26,580 | 24,864 | 23,189 | 18,543 | 11,726 | 0 | 0 | 0 | - | - | - | - |
Non-cash interest expense | ||||||||||||
- | - | - | - | - | - | - | - | - | 784 | 0 | 0 | 0 |
Change in fair value of derivative liability | ||||||||||||
9,656 | 3,875 | 0 | 0 | 0 | - | - | - | - | -512 | 0 | 0 | 0 |
Change in fair value of warrant liability | ||||||||||||
- | - | - | - | - | 1,182 | -1,086 | 1,340 | 3,969 | 3,241 | 0 | 0 | 0 |
Change in fair value of contingent equity liability | ||||||||||||
- | - | - | - | - | - | - | - | - | 13,082 | 0 | 0 | 0 |
Loss from equity method investment | ||||||||||||
-6,556 | -6,076 | -5,050 | -3,754 | -2,980 | -2,808 | -2,747 | -2,688 | -2,395 | -1,885 | 0 | 0 | 0 |
Other non-cash items | ||||||||||||
-989 | -646 | -615 | -487 | -385 | -269 | -105 | -101 | -85 | -64 | 0 | 0 | 0 |
Changes in operating assets and liabilities: | ||||||||||||
Trade receivables, net | ||||||||||||
0 | - | - | - | 0 | - | - | - | - | - | - | - | - |
Inventories | ||||||||||||
0 | - | - | - | 0 | - | - | - | - | - | - | - | - |
Prepaid expenses and other current assets | ||||||||||||
27,321 | 3,464 | -8,199 | -1,537 | -501 | 2,893 | 11,046 | 5,847 | 9,520 | 4,730 | 0 | 0 | 0 |
Other assets | ||||||||||||
183 | 232 | 287 | -19 | 8 | -21 | 0 | 0 | 0 | - | - | - | - |
Accounts payable | ||||||||||||
20,336 | 3,319 | 6,263 | 8,201 | -1,376 | 5,390 | -4,066 | 10 | 5,543 | 3,975 | 0 | 0 | 0 |
Accrued expenses and other current liabilities | ||||||||||||
39,479 | 43,320 | 25,038 | 22,439 | 10,425 | 3,697 | -3,509 | 1,287 | -1,677 | 1,341 | 0 | 0 | 0 |
Other long-term liabilities | ||||||||||||
61 | -1,975 | -2,052 | -1,380 | -1,410 | 576 | 595 | -21 | 10 | 29 | 0 | 0 | 0 |
Net cash used in operating activities | ||||||||||||
-481,184 | -377,331 | -310,300 | -288,908 | -162,477 | -197,141 | -204,492 | -177,102 | -168,696 | -94,815 | 0 | 0 | 0 |
Purchases of property and equipment | ||||||||||||
2,512 | 2,534 | 3,168 | 4,112 | 4,846 | 4,165 | 2,922 | 1,993 | 877 | 541 | 0 | 0 | 0 |
Purchase of equity method investment | ||||||||||||
- | - | - | - | - | 6,375 | 5,003 | 5,003 | 6,378 | 6,627 | 0 | 0 | 0 |
Payments for leasehold improvements | ||||||||||||
0 | - | - | - | 0 | - | - | - | - | - | - | - | - |
Payments for intangible assets | ||||||||||||
0 | - | - | - | 0 | - | - | - | - | - | - | - | - |
Net cash used in investing activities | ||||||||||||
-26,112 | -3,784 | -8,168 | -9,112 | -9,846 | -10,540 | -7,925 | -6,996 | -7,255 | -7,168 | 0 | 0 | 0 |
Proceeds from issuance of common shares | ||||||||||||
586,554 | 303,221 | 438,346 | 417,125 | 135,125 | 190,125 | 0 | 0 | 0 | - | - | - | - |
Payments of issuance costs | ||||||||||||
1,490 | 1,150 | 0 | 0 | 0 | - | - | - | - | 5,068 | 0 | 0 | 0 |
Proceeds from issuance of Series A preferred shares | ||||||||||||
- | - | - | - | - | - | - | - | - | - | 0 | 0 | 0 |
Proceeds from exercise of stock options | ||||||||||||
7,066 | 5,524 | 3,663 | 2,701 | 3,386 | 3,324 | 0 | 0 | 0 | - | - | - | - |
Net cash provided by financing activities | ||||||||||||
719,128 | 434,593 | 567,857 | 546,307 | 285,524 | 340,462 | 204,848 | 197,260 | 227,811 | 209,759 | 0 | 0 | 0 |
Net increase in cash and restricted cash | ||||||||||||
211,832 | 53,478 | 249,389 | 248,287 | 113,201 | 132,781 | -7,569 | 13,162 | 51,860 | 107,776 | 0 | 0 | 0 |
Supplemental disclosure of cash flow information: | ||||||||||||
Cash paid for interest | ||||||||||||
0 | 0 | 0 | 0 | 0 | 0 | 0 | 24 | 97 | 122 | 0 | 0 | 0 |
Cash paid for income taxes | ||||||||||||
415 | 823 | 895 | 738 | 661 | 333 | 0 | 0 | 0 | - | - | - | - |
Supplemental disclosure of non-cash investing and financing activities: | ||||||||||||
Deferred offering costs included in accounts payable | ||||||||||||
0 | - | 0 | 0 | 0 | - | 0 | 0 | 0 | - | 0 | 0 | 0 |
Intangible asset costs included in accounts payable | ||||||||||||
0 | - | - | - | 0 | - | - | - | - | - | - | - | - |
Deferred offering costs included in accounts payable and accrued expenses | ||||||||||||
- | - | - | - | - | - | - | - | - | - | - | - | 0 |
Beneficial conversion feature on Series A preferred shares | ||||||||||||
- | - | - | - | - | - | - | - | - | -12,006 | 0 | 0 | 0 |
Accretion of beneficial conversion feature on Series A preferred shares | ||||||||||||
- | - | - | - | - | - | - | - | - | 12,006 | 0 | 0 | 0 |
Issuance of Series A preferred shares as payment of offering costs | ||||||||||||
- | - | - | - | - | - | - | - | - | 1,242 | 0 | 0 | 0 |
Issuance of common shares as payment of equity investment | ||||||||||||
- | - | - | - | - | - | - | - | - | 352 | 0 | 0 | 0 |