| Dec'19 | Dec'18 | Dec'17 | Dec'16 | Dec'15 | Dec'14 | Dec'13 |
|---|---|---|---|---|---|---|
Cash flows from operating activities: | ||||||
Net income (loss) | ||||||
-112,477 | -98,036 | -91,779 | -69,241 | -48,548 | -83,965 | -7,969 |
Adjustments to reconcile net loss to net cash used in operating activities: | ||||||
Adjustments to reconcile net loss to net cash used in operating activities: | ||||||
Share-based compensation | ||||||
7,338 | 13,824 | 13,569 | 12,337 | 8,409 | 911 | 391 |
Depreciation and amortization expense | ||||||
7,175 | 6,698 | - | - | - | - | - |
Loss on extinguishment of debt | ||||||
- | - | -1,786 | 0 | 0 | - | - |
(Gain)/Loss on disposal of property and equipment | ||||||
- | - | 11 | -10 | -42 | 0 | 0 |
Change in fair value of warrant and private placement option liabilities | ||||||
19,192 | 0 | - | - | - | - | - |
Impairment of intangible assets | ||||||
2,064 | 0 | - | - | - | - | - |
Depreciation and amortization expense | ||||||
- | - | 3,564 | 2,306 | 1,199 | 667 | 587 |
Amortization of discount on investment securities, net | ||||||
30 | -94 | -302 | -539 | -573 | 0 | 0 |
Amortization of right-of-use assets | ||||||
1,331 | 0 | - | - | - | - | - |
Accretion of lease liability | ||||||
-804 | 276 | 102 | 119 | 94 | 89 | - |
Amortization of lease liability | ||||||
- | - | - | - | - | - | -95 |
Amortization of deferred issuance costs | ||||||
885 | 886 | 774 | 422 | 0 | 0 | - |
Loss on disposition of fixed assets | ||||||
-6 | -10 | - | - | - | - | - |
Warrant and private placement option issuance costs | ||||||
3,047 | 0 | - | - | - | - | - |
Loss on disposition of investment securities | ||||||
- | - | - | 0 | -33 | 0 | 0 |
Interest expense converted into preferred stock | ||||||
- | - | - | - | - | - | 3 |
Change in fair value of warrant liability | ||||||
- | - | - | - | - | 24,371 | 0 |
Changes in operating assets and liabilities: | ||||||
Changes in operating assets and liabilities: | ||||||
Accounts receivable, interest and other receivables | ||||||
-606 | 589 | -14 | -106 | 142 | -448 | 745 |
Prepaid expenses and other assets | ||||||
1,096 | -1,070 | 930 | -885 | 1,067 | 1,068 | -592 |
Other assets | ||||||
- | - | 95 | -47 | 185 | -339 | 287 |
Accounts payable | ||||||
-1,131 | 460 | -512 | 931 | 897 | 659 | -1 |
Accrued liabilities and other | ||||||
-2,300 | 2,197 | -3,667 | 1,336 | 2,778 | 225 | 698 |
Deferred revenue | ||||||
-2,983 | -1,120 | 4,103 | - | - | - | - |
Deferred revenue | ||||||
- | - | - | 0 | -13 | 13 | -1,039 |
Deferred rent | ||||||
- | - | - | 0 | 859 | 5 | 14 |
Deferred manufacturing costs | ||||||
- | - | - | 0 | -467 | 176 | 239 |
Net cash used in operating activities | ||||||
-77,569 | -74,782 | -72,984 | -50,441 | -35,726 | -57,308 | -7,612 |
Cash flows from investing activities: | ||||||
Purchases of investment securities | ||||||
- | - | 54,895 | 33,276 | 101,649 | 0 | 0 |
Cash flows from investing activities: | ||||||
Purchases of investment securities | ||||||
0 | 59,335 | - | - | - | - | - |
Proceeds from sale of investment securities | ||||||
49,379 | 71,362 | 63,737 | 42,548 | 20,617 | 0 | 0 |
Proceeds on disposition of equipment | ||||||
- | - | 39 | 0 | 0 | - | - |
Purchases of property and equipment | ||||||
522 | 1,617 | 12,134 | 7,220 | 5,421 | 804 | 366 |
Net cash (used in) provided by investing activities | ||||||
48,857 | 10,410 | -3,253 | 2,052 | -86,453 | -804 | -366 |
Cash flows from financing activities: | ||||||
Proceeds from issuance of stock from employee stock purchase plan | ||||||
98 | 205 | - | - | - | - | - |
Proceeds from debt | ||||||
- | - | 45,000 | 20,000 | 0 | 386 | - |
Payment on debt | ||||||
- | - | 32,688 | 0 | 0 | 1,187 | - |
Proceeds from issuance of common stock, net | ||||||
- | - | 64,860 | 0 | 0 | 160,609 | 0 |
Proceeds from issuance of common stock in a public offering, net | ||||||
8,977 | 64,860 | - | - | - | - | - |
Proceeds from issuance of redeemable convertible preferred stock in a public offering, net | ||||||
22,944 | 0 | - | - | - | - | - |
Proceeds from issuance of warrants in a public offering, net | ||||||
30,888 | 0 | - | - | - | - | - |
Proceeds received from private placement option, net | ||||||
11,152 | 0 | - | - | - | - | - |
Proceeds from issuance of stock from employee stock purchase plan | ||||||
- | - | 293 | 369 | 347 | 0 | - |
Proceeds from exercise of stock options | ||||||
76 | 3,300 | 1,486 | 773 | 482 | 0 | 0 |
Proceeds from notes payable | ||||||
- | - | - | - | - | - | 3,500 |
Payments of Debt Issuance Costs | ||||||
- | - | 150 | 199 | 0 | 0 | - |
Payment on financing lease obligations | ||||||
47 | 31 | 23 | 15 | 4 | 0 | 0 |
Payment of issuance costs on common stock | ||||||
0 | 195 | 292 | 0 | 7 | 14,242 | 0 |
Proceeds from issuance of preferred stock | ||||||
- | - | - | - | - | 62,320 | 13,671 |
Payment of issuance costs on preferred stock | ||||||
- | - | - | - | - | 3,524 | 7 |
Proceeds from exercise of preferred warrants | ||||||
- | - | - | - | - | 39,145 | 0 |
Proceeds from exercise of common warrants | ||||||
- | - | - | - | - | 249 | 0 |
Payment for repurchase of common stock | ||||||
- | - | - | - | - | 5,056 | 0 |
Payment of preferred dividends | ||||||
- | - | - | - | - | 155 | 0 |
Proceeds from line of credit or notes payable or debt | ||||||
- | - | - | - | - | - | 550 |
Payments on line of credit | ||||||
- | - | - | - | - | - | 200 |
Net cash (used in) provided by financing activities | ||||||
74,088 | 68,109 | 78,486 | 20,928 | 818 | 238,546 | 17,514 |
Effect of exchange rate changes on cash | ||||||
-228 | -98 | - | - | - | - | - |
EFFECT OF EXCHANGE RATE CHANGES ON CASH | ||||||
- | - | 0 | - | - | - | - |
Net change in cash, cash equivalents, and restricted cash | ||||||
45,148 | 3,639 | 2,249 | - | - | - | - |
NET CHANGE IN CASH, CASH EQUIVALENTS AND RESTRICTED CASH | ||||||
- | - | - | -27,461 | -121,361 | 180,434 | - |
NET CHANGE IN CASH AND CASH EQUIVALENTS | ||||||
- | - | - | - | - | - | 9,536 |
Supplemental cash flow information: | ||||||
Cash paid during the period for interest | ||||||
3,201 | 3,025 | 2,951 | - | - | - | - |
Interest paid | ||||||
- | - | - | 1,136 | 0 | 1,767 | 47 |
Non-cash investing and financing activities: | ||||||
Non-cash investing and financing activities: | ||||||
Purchases of property and equipment in accounts payables and accrued liabilities | ||||||
0 | 27 | 872 | 3,533 | 139 | 0 | 0 |
Financing leases incurred for equipment | ||||||
167 | 0 | - | - | - | - | - |
Conversion of redeemable preferred stock into common stock | ||||||
1,476 | 0 | - | - | - | - | - |
Reclassification of property and equipment, net to assets held for sale | ||||||
12,039 | 0 | - | - | - | - | - |
Leasehold improvements paid by landlord | ||||||
- | - | - | 1,139 | 0 | 0 | - |
Accrued debt issuance costs | ||||||
- | - | 3,045 | 1,390 | 0 | 0 | - |
Capital lease obligations incurred for equipment | ||||||
- | - | 23 | 46 | 135 | 0 | 0 |
Conversion of notes payable into preferred stock | ||||||
- | - | - | - | - | - | 3,500 |
Preferred stock dividends paid in common stock | ||||||
- | - | - | - | - | 3,196 | 0 |
Dividends accreted on preferred stock | ||||||
- | - | - | - | - | 1,432 | 1,094 |