| Dec'18 | Dec'17 | Dec'16 | Dec'15 | Dec'14 | ||
|---|---|---|---|---|---|---|
Cash flows from operating activities: | ||||||
Net loss | ||||||
-128,821 | -90,238 | -59,668 | -26,458 | -10,819 | ||
Adjustments to reconcile net loss to net cash used in operating activities: | ||||||
Amortization of discount on investments | ||||||
- | - | - | - | 0 | ||
Depreciation and amortization | ||||||
5,595 | 3,398 | 1,630 | 166 | 35 | ||
Stock-based compensation | ||||||
16,495 | 6,880 | 2,004 | 1,291 | 515 | ||
Deferred income taxes | ||||||
0 | -2,246 | 0 | 0 | - | ||
Accretion of discount on marketable securities | ||||||
1,861 | 350 | -51 | -660 | - | ||
Accretion of asset retirement obligation | ||||||
50 | 34 | 106 | 136 | 0 | ||
Business Combination, Contingent Consideration Arrangements, Change in Amount of Contingent Consideration, Liability | ||||||
-2,298 | 263 | 102 | 131 | 0 | ||
Other | ||||||
-555 | -337 | -71 | 0 | 9 | ||
Changes in operating assets and liabilities: | ||||||
Restricted cash | ||||||
- | - | - | 3,610 | 0 | ||
Prepaid expenses and other current assets | ||||||
2,150 | 675 | -1,085 | 3,188 | 300 | ||
Other assets | ||||||
3,260 | 2,012 | -27 | 195 | 36 | ||
Accounts payable | ||||||
4,081 | 686 | -671 | 628 | 857 | ||
Accrued liabilities | ||||||
2,017 | -1,579 | 4,815 | 2,634 | 1,683 | ||
Deferred rent | ||||||
-1,619 | -937 | -1,522 | -290 | -5 | ||
Net cash used in operating activities | ||||||
-107,978 | -84,565 | -48,926 | -27,515 | -8,069 | ||
Cash acquired from acquisition | ||||||
- | - | - | 142 | 0 | ||
Purchases of property and equipment | ||||||
11,609 | 7,551 | 16,651 | 1,686 | 125 | ||
Proceeds from sales of property and equipment | ||||||
0 | 0 | 16 | 0 | 0 | ||
Proceeds from maturities of marketable securities | ||||||
208,586 | 126,828 | 58,624 | 32,792 | 0 | ||
Purchases of marketable securities | ||||||
382,025 | 152,713 | 104,037 | 40,124 | 16,539 | ||
Net cash used in investing activities | ||||||
-185,048 | -33,436 | -62,048 | -8,876 | -16,664 | ||
Proceeds from exercise of stock options and ESPP purchases | ||||||
4,049 | 828 | 157 | 70 | 0 | ||
Proceeds from issuance of common stock, net of issuance costs | ||||||
394,413 | 119,725 | 75,208 | 0 | 0 | ||
Net cash provided by financing activities | ||||||
398,462 | 120,553 | 75,365 | 62,850 | 57,386 | ||
Net (decrease) increase in cash, cash equivalents and restricted cash | ||||||
105,436 | 2,552 | -35,609 | 26,459 | 32,653 | ||
Noncash investing and financing activities: | ||||||
Change in accounts payable and accrued liabilities related to property and equipment purchases | ||||||
2,407 | 1,239 | 927 | 1,140 | 65 | ||
Issuance of common stock warrant related to debt financing facility | ||||||
0 | 83 | 0 | 0 | - | ||
Conversion of redeemable convertible preferred stock to common stock at closing of initial public offering | ||||||
0 | 0 | 135,750 | 0 | 0 | ||
Deferred financing costs for follow-on offering | ||||||
136 | 0 | 2,333 | 0 | 0 | ||
Preferred stock issuance costs | ||||||
- | - | - | 140 | -120 | ||
Issuance of common stock in exchange for license | ||||||
- | - | - | 128 | 0 | ||