| Dec'19 | Dec'18 | Dec'17 | Dec'16 | Dec'15 | Dec'14 | Dec'13 | Dec'12 | Dec'11 | Dec'10 | Dec'09 |
|---|---|---|---|---|---|---|---|---|---|---|
License and collaboration revenue | ||||||||||
- | 6 | 1,018 | - | - | - | - | - | - | - | - |
Contract revenue | ||||||||||
- | - | - | 399 | 1,750 | 1,813 | 523 | - | - | - | - |
License fees and milestones from collaborations | ||||||||||
- | - | - | - | - | - | - | 57,420 | 96,979 | 83,380 | 18,934 |
Collaboration research and development | ||||||||||
- | - | - | - | - | - | - | - | - | - | 5,246 |
Product sales, net | ||||||||||
- | - | - | - | - | - | - | - | - | - | 473 |
Grant and other revenue | ||||||||||
- | - | - | - | - | - | - | 440 | 658 | 2,333 | 409 |
Net operating revenues | ||||||||||
- | - | - | - | - | - | - | 57,860 | 97,637 | 85,713 | 25,062 |
Operating expenses: | ||||||||||
Reductions in force (including stock-based compensation of $98 in 2012) | ||||||||||
- | - | - | - | - | - | - | 3,718 | - | - | - |
License fees | ||||||||||
- | - | - | - | - | - | - | - | - | - | 16,350 |
Cost of product sales | ||||||||||
- | - | - | - | - | - | - | - | - | - | 691 |
Total operating expenses | ||||||||||
57,277 | 33,828 | 22,840 | 20,817 | 15,552 | 9,322 | 10,643 | 65,998 | 107,382 | 72,598 | 65,387 |
Research and development | ||||||||||
43,859 | 21,474 | 12,847 | 11,555 | 5,958 | 5,267 | 6,557 | 49,087 | 95,215 | 64,546 | 40,179 |
General and administrative | ||||||||||
13,418 | 12,354 | 9,993 | 9,262 | 9,594 | 4,055 | 4,086 | 13,193 | 12,167 | 8,052 | 8,167 |
Loss from operations | ||||||||||
-57,277 | -33,822 | -21,822 | -20,418 | -13,802 | -7,509 | -10,120 | -8,138 | -9,745 | 13,115 | -40,325 |
Interest and other income, net | ||||||||||
2,099 | 3,767 | 261 | 3,473 | 518 | 896 | 154 | - | - | - | - |
Interest income | ||||||||||
- | - | - | - | - | - | - | 1,070 | 1,348 | - | - |
Gain (loss) on sale of property and equipment | ||||||||||
- | - | - | - | - | - | - | 55 | - | - | - |
Interest income | ||||||||||
- | - | - | - | - | - | - | - | - | 1,463 | 1,050 |
Interest expense | ||||||||||
- | - | - | - | 1,478 | - | - | 86 | 132 | 153 | 217 |
Total other income (expense) | ||||||||||
- | - | - | - | - | - | - | 1,039 | 1,216 | 1,310 | 833 |
Loss before taxes | ||||||||||
- | - | - | - | - | - | - | -7,099 | -8,529 | 14,425 | -39,492 |
Income tax expense | ||||||||||
- | - | - | - | - | - | - | -101 | 0 | 3,526 | -88 |
Net loss | ||||||||||
-55,178 | -30,055 | -21,561 | -16,945 | -14,762 | -6,613 | -9,966 | -6,998 | -8,529 | 10,899 | -39,404 |
Deemed dividend for convertible preferred stock beneficial conversion feature | ||||||||||
- | - | 3,951 | - | - | - | - | - | - | - | - |
Net loss attributable to common stockholders | ||||||||||
- | - | -25,512 | -16,945 | - | - | - | - | - | - | - |
Net loss per share attributable to common stockholders, basic and diluted | ||||||||||
-4.60 | -2.68 | -7.45 | -21.75 | -49.99 | -17.99 | -27.29 | -0.21 | -0.27 | - | - |
Shares used to compute net loss per share attributable to common stockholders, basic and diluted | ||||||||||
12,004 | 11,213 | 3,423 | 779 | 295 | 367 | 365 | 33,476 | 31,637 | - | - |
Basic net (loss) income per share | ||||||||||
- | - | - | - | - | - | - | - | - | 0.38 | -1.54 |
Diluted net (loss) income per share | ||||||||||
- | - | - | - | - | - | - | - | - | 0.36 | -1.54 |
Weighted average common shares outstanding - basic | ||||||||||
- | - | - | - | - | - | - | - | - | 28,543 | 25,636 |
Weighted average common shares outstanding - diluted | ||||||||||
- | - | - | - | - | - | - | - | - | 30,150 | 25,636 |
Net loss | ||||||||||
-55,178 | -30,055 | -21,561 | -16,945 | - | - | - | -6,998 | -8,529 | 10,899 | -39,404 |
Unrealized (loss) gain on available-for-sale securities, net | ||||||||||
- | - | - | - | - | - | - | 165 | -189 | 225 | - |
Comprehensive loss | ||||||||||
- | - | - | - | - | - | - | -6,833 | -8,718 | 11,124 | - |