| Dec'19 | Dec'18 | Dec'17 | Dec'16 | Dec'15 | Dec'14 | Dec'13 | Dec'12 | Dec'11 | Dec'10 |
|---|---|---|---|---|---|---|---|---|---|
Revenue: | |||||||||
Collaboration and license revenue from related party | |||||||||
35,952 | 42,875 | 82,497 | 11,435 | - | - | 6,060 | 5,419 | 31,673 | 34,861 |
Grant revenue | |||||||||
176 | 0 | 0 | 500 | - | - | - | - | - | - |
Total revenue | |||||||||
36,128 | 42,875 | 82,497 | 11,935 | - | - | - | - | - | - |
Operating expenses: | |||||||||
Research and development | |||||||||
70,276 | 62,736 | 49,495 | 37,945 | 33,183 | 33,815 | 33,541 | 34,569 | 28,359 | 33,527 |
General and administrative | |||||||||
24,155 | 20,409 | 16,509 | 14,710 | 14,506 | 13,584 | 11,634 | 10,480 | 7,615 | 7,292 |
Total operating expenses | |||||||||
94,431 | 83,145 | 66,004 | 52,655 | 47,689 | 47,399 | 45,175 | 45,049 | 35,974 | 40,819 |
Loss from operations | |||||||||
-58,303 | -40,270 | 16,493 | -40,720 | -47,689 | -47,399 | -39,115 | -39,630 | -4,301 | -5,958 |
Other income (expense): | |||||||||
Interest income | |||||||||
4,963 | 3,528 | 1,370 | 757 | 384 | 494 | 501 | 533 | 402 | 436 |
Interest expense | |||||||||
2,149 | 1,224 | 4 | - | - | 24 | 59 | 794 | 734 | 81 |
Other income | |||||||||
- | - | - | - | - | - | - | - | 16 | 2,434 |
Total other income, net | |||||||||
2,814 | 2,304 | 1,366 | 757 | 384 | 470 | 442 | -261 | -316 | - |
Loss before provision for income taxes | |||||||||
- | - | - | - | - | - | - | - | - | -3,169 |
Income tax benefit | |||||||||
- | - | - | - | - | - | - | - | - | -73 |
Net loss | |||||||||
-55,489 | -37,966 | 17,859 | -39,963 | -47,305 | -46,929 | -38,673 | -39,891 | -4,617 | -3,096 |
Net (loss) income per common share | |||||||||
Basic | |||||||||
-0.98 | -0.76 | 0.37 | -0.86 | -1.08 | - | - | - | - | - |
Diluted | |||||||||
-0.98 | -0.76 | 0.36 | -0.86 | -1.08 | - | - | - | - | - |
Shares used to compute net (loss) income per common share | |||||||||
Basic | |||||||||
56,898 | 49,814 | 48,413 | 46,432 | 43 | - | - | - | - | - |
Diluted | |||||||||
56,898 | 49,814 | 49,615 | 46,432 | 43 | - | - | - | - | - |
Basic and diluted net loss per common share | |||||||||
- | - | - | - | - | -1.08 | -0.95 | -1.13 | -1.10 | -0.76 |
Shares used to compute basic and diluted net loss per common share | |||||||||
- | - | - | - | - | 43 | 40 | 35,407 | 4 | 4,081 |