| Mar'20 | Dec'19 | Sep'19 | Jun'19 | Mar'19 | Dec'18 | Sep'18 | Jun'18 | Mar'18 | Dec'17 | Sep'17 | Jun'17 | Mar'17 | Dec'16 | Sep'16 | Jun'16 | Mar'16 | Dec'15 | Sep'15 | Jun'15 | Mar'15 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Cash flows from operating activities: | ||||||||||||||||||||
Net loss | ||||||||||||||||||||
-9,353 | -5,433 | -8,701 | -6,763 | -7,581 | -9,870 | -7,437 | -14,057 | -12,001 | -11,858 | -12,472 | -12,090 | -17,160 | -15,740 | -12,762 | -14,052 | -15,034 | -14,990 | -17,107 | -10,892 | -14,257 |
Adjustments to reconcile net loss to net cash provided by (used in) operating activities: | ||||||||||||||||||||
Depreciation and amortization expense | ||||||||||||||||||||
1,077 | 1,045 | 1,056 | 1,071 | 1,065 | 1,107 | 1,062 | 1,005 | 948 | 971 | 950 | 905 | 843 | 819 | 791 | 809 | 734 | 728 | 692 | 651 | 548 |
Amortization of debt discount | ||||||||||||||||||||
- | - | - | - | - | - | - | - | - | - | - | - | - | 4 | 0 | 2 | 1 | 0 | 114 | 12 | 9 |
Stock-based compensation expense | ||||||||||||||||||||
766 | 658 | 73 | 958 | 1,148 | 1,142 | 960 | 911 | 873 | 1,899 | 1,408 | 1,449 | 1,292 | 1,834 | 1,359 | 1,187 | 944 | 1,013 | 748 | 758 | 1,088 |
Unrealized foreign exchange loss | ||||||||||||||||||||
-675 | 900 | -1,277 | 410 | -639 | -556 | -165 | -2,079 | 994 | - | - | - | - | - | - | - | - | - | - | - | - |
Non-cash lease expense | ||||||||||||||||||||
288 | 283 | 279 | 274 | 310 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - |
Provision for bad debts on trade receivables | ||||||||||||||||||||
23 | 48 | 77 | -19 | 0 | -56 | 6 | -2 | -20 | -20 | 9 | -33 | 29 | -55 | 53 | 190 | 0 | 188 | 7 | 122 | 42 |
Non-cash interest expense | ||||||||||||||||||||
175 | 198 | 8 | 191 | 26 | 43 | 27 | 28 | 27 | 27 | 27 | 32 | 14 | 0 | 0 | 0 | 0 | - | - | - | - |
Amortization/accretion on investments | ||||||||||||||||||||
0 | 0 | 0 | 0 | 4 | 35 | 34 | -18 | -33 | -43 | -42 | -42 | -75 | -86 | -101 | -128 | 0 | - | - | - | - |
Deferred tax | ||||||||||||||||||||
- | - | - | - | - | -36 | 16 | 0 | -17 | -5 | 42 | 0 | 0 | - | - | - | - | - | - | - | - |
Changes in operating assets and liabilities: | ||||||||||||||||||||
Accounts receivable | ||||||||||||||||||||
-2,881 | 638 | -695 | -1,761 | -252 | 1,524 | -345 | 124 | -1,331 | 581 | 740 | -1,217 | -1,594 | 781 | 814 | -267 | -1,332 | 6,794 | -2,762 | 1,361 | 714 |
Royalty receivable | ||||||||||||||||||||
-15 | -5 | 2 | 20 | 3 | -10,489 | 10,434 | 0 | 0 | - | - | - | - | - | - | - | - | - | - | - | - |
Inventories | ||||||||||||||||||||
-216 | 516 | 919 | 1,077 | 27 | -525 | 999 | 881 | -1,005 | -1,392 | -1,207 | 401 | -337 | -35 | -222 | 58 | 399 | 855 | 1,286 | 340 | 1,348 |
Prepaid expenses and other assets | ||||||||||||||||||||
-952 | 1,369 | -70 | 255 | 69 | -113 | -209 | -192 | -15 | -266 | -98 | -312 | -1,094 | 1,762 | 417 | -74 | -555 | 76 | 721 | -1,309 | 1,557 |
Accounts payable, accrued expenses and other liabilities | ||||||||||||||||||||
-1,883 | 639 | 1,540 | -894 | 330 | -866 | -2,233 | 1,252 | 802 | -38 | -665 | -1,380 | 677 | 3,329 | 1,577 | -4,163 | 694 | -273 | -1,700 | 1,361 | 2,581 |
Advance on research and development | ||||||||||||||||||||
-310 | - | - | - | -324 | - | - | - | 0 | - | - | - | - | - | - | - | - | - | - | - | - |
Deferred royalty revenue | ||||||||||||||||||||
- | - | - | - | - | - | - | - | - | - | - | -77 | -76 | - | -76 | -77 | -76 | -77 | -75 | 5,084 | 0 |
Other long-term liabilities | ||||||||||||||||||||
- | - | - | - | - | - | - | - | -2 | -1 | 201 | 290 | -3 | -2 | -1 | -33 | -20 | -20 | -6 | 24 | -49 |
Net cash used in operating activities | ||||||||||||||||||||
-4,478 | -4,339 | 9,513 | -3,774 | -4,238 | 2,079 | -9,676 | -9,579 | -8,000 | - | - | - | - | - | - | - | - | - | - | - | - |
Net cash used in operating activities | ||||||||||||||||||||
- | - | - | - | - | - | - | - | - | - | - | -9,734 | -11,284 | -12,292 | -9,839 | -15,732 | -11,269 | -20,951 | -12,081 | -7,761 | -13,657 |
Cash flows from investing activities: | ||||||||||||||||||||
Acquisition of property and equipment | ||||||||||||||||||||
1,477 | 824 | 804 | 541 | 757 | 1,113 | 604 | 1,042 | 1,300 | 1,119 | 1,082 | 1,576 | 1,456 | 872 | 2,101 | 890 | 3,298 | 977 | 689 | 1,562 | 1,415 |
(Increase) decrease in restricted cash | ||||||||||||||||||||
- | - | - | - | - | - | - | - | - | 0 | -300 | 0 | 462 | 0 | 0 | -300 | 0 | -120 | -3,608 | -53 | -56 |
Purchase of short term investment | ||||||||||||||||||||
- | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | 26,939 | - | - | - | 0 |
Purchase of investments | ||||||||||||||||||||
- | - | - | - | - | 7,981 | 5,253 | 10,952 | 3,244 | 7,989 | 2,515 | 6,917 | 13,570 | - | - | - | - | - | - | - | - |
Maturity of investments | ||||||||||||||||||||
0 | 0 | 0 | 0 | 7,250 | 16,020 | 7,500 | 12,700 | 10,895 | 9,000 | 6,500 | 7,000 | 9,625 | 20,550 | 11,000 | 5,500 | 0 | - | - | - | - |
Net cash (used in) provided by investing activities | ||||||||||||||||||||
-1,477 | -824 | -804 | -541 | 6,493 | 6,926 | 1,643 | 706 | 6,351 | - | - | - | - | - | - | - | - | - | - | - | - |
Net cash provided/(used) in investing activities | ||||||||||||||||||||
- | - | - | - | - | - | - | - | - | - | - | -1,493 | -5,863 | 11,623 | 6,703 | -23,514 | -30,237 | -857 | 2,919 | -1,509 | -1,359 |
Cash flows from financing activities: | ||||||||||||||||||||
Proceeds from exercise of common stock options | ||||||||||||||||||||
- | - | - | - | - | - | - | - | - | 6 | 87 | 82 | 1,933 | 1,874 | 552 | 836 | 825 | 245 | 172 | 263 | 126 |
Debt issuance costs | ||||||||||||||||||||
- | - | - | - | - | - | - | - | - | 0 | 0 | 137 | 297 | 0 | 0 | 0 | 0 | - | - | - | - |
Proceeds from issuance of debt | ||||||||||||||||||||
- | - | - | - | - | - | - | - | - | 0 | 0 | 15,000 | 15,000 | 0 | 0 | 0 | 0 | - | - | - | - |
Payments on long-term debt | ||||||||||||||||||||
- | - | - | - | - | - | - | - | - | - | - | - | - | 261 | 77 | 75 | 72 | 71 | 10,070 | 69 | 68 |
Net proceeds from issuance of common stock | ||||||||||||||||||||
1,141 | 1,999 | 0 | 3,000 | 0 | 944 | 500 | 0 | 21,324 | 0 | 0 | 1,023 | 0 | - | - | - | - | - | - | - | - |
Net cash provided by financing activities | ||||||||||||||||||||
1,141 | 2,062 | 114 | 6,351 | 0 | -14,281 | 500 | 112 | 21,324 | - | - | - | - | - | - | - | - | - | - | - | - |
Foreign exchange effect on cash and cash equivalents | ||||||||||||||||||||
-62 | 62 | -49 | 7 | -19 | -29 | 96 | -195 | 55 | - | - | - | - | - | - | - | - | - | - | - | - |
(Decrease) increase in cash, cash equivalents and restricted cash | ||||||||||||||||||||
-4,876 | -3,039 | 8,774 | 2,043 | 2,236 | -5,305 | -7,437 | -8,956 | 19,730 | - | - | - | - | - | - | - | - | - | - | - | - |
Net cash provided by financing activities | ||||||||||||||||||||
- | - | - | - | - | - | - | - | - | - | - | 15,968 | 16,636 | 1,613 | 475 | 761 | 753 | -31 | 133,928 | 610 | 58 |
Foreign exchange effect on cash and cash equivalents | ||||||||||||||||||||
- | - | - | - | - | - | - | - | - | -423 | -1,006 | -1,926 | -354 | 1,327 | -166 | -285 | 151 | -178 | -60 | 217 | -3 |
Decrease in cash and cash equivalents | ||||||||||||||||||||
- | - | - | - | - | - | - | - | - | -8,199 | -12,660 | 2,815 | -865 | 2,271 | -2,827 | -38,770 | -40,602 | -22,017 | 124,706 | -8,443 | -14,961 |
Supplemental information: | ||||||||||||||||||||
Cash paid for income taxes | ||||||||||||||||||||
- | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | 10 | - | - | - | 29 |
Cash paid for interest | ||||||||||||||||||||
346 | 351 | 347 | 1,094 | 331 | 950 | 653 | 636 | 598 | 589 | 492 | 61 | 307 | - | - | - | 8 | - | - | - | 242 |
Noncash Investing and Financing Items [Abstract] | ||||||||||||||||||||
Operating leases right-of-use assets obtained in exchange for lease obligations | ||||||||||||||||||||
0 | - | 0 | 0 | 6,988 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - |