| Mar'20 | Dec'19 | Sep'19 | Jun'19 | Mar'19 | Dec'18 | Sep'18 | Jun'18 | Mar'18 | Dec'17 | Sep'17 | Jun'17 | Mar'17 | Dec'16 | Sep'16 | Jun'16 | Mar'16 | Dec'15 | Sep'15 | Jun'15 | Mar'15 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Cash flows from operating activities: | ||||||||||||||||||||
Net loss | ||||||||||||||||||||
-30,250 | -28,478 | -32,915 | -31,651 | -38,945 | -43,365 | -45,353 | -50,388 | -48,421 | -53,580 | -57,462 | -57,752 | -59,714 | -57,588 | -56,838 | -61,183 | -58,023 | -57,246 | 0 | 0 | 0 |
Adjustments to reconcile net loss to net cash provided by (used in) operating activities: | ||||||||||||||||||||
Depreciation and amortization expense | ||||||||||||||||||||
4,249 | 4,237 | 4,299 | 4,305 | 4,239 | 4,122 | 3,986 | 3,874 | 3,774 | 3,669 | 3,517 | 3,358 | 3,262 | 3,153 | 3,062 | 2,963 | 2,805 | 2,619 | 0 | 0 | 0 |
Amortization of debt discount | ||||||||||||||||||||
- | - | - | - | - | - | - | - | - | - | - | - | - | 7 | 3 | 117 | 127 | 135 | 0 | 0 | 0 |
Stock-based compensation expense | ||||||||||||||||||||
2,455 | 2,837 | 3,321 | 4,208 | 4,161 | 3,886 | 4,643 | 5,091 | 5,629 | 6,048 | 5,983 | 5,934 | 5,672 | 5,324 | 4,503 | 3,892 | 3,463 | 3,607 | 0 | 0 | 0 |
Unrealized foreign exchange loss | ||||||||||||||||||||
-642 | -606 | -2,062 | -950 | -3,439 | -1,806 | 0 | 0 | 0 | - | - | - | - | - | - | - | - | - | - | - | - |
Non-cash lease expense | ||||||||||||||||||||
1,124 | 1,146 | 0 | 0 | 0 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - |
Provision for bad debts on trade receivables | ||||||||||||||||||||
129 | 106 | 2 | -69 | -52 | -72 | -36 | -33 | -64 | -15 | -50 | -6 | 217 | 188 | 431 | 385 | 317 | 359 | 0 | 0 | 0 |
Non-cash interest expense | ||||||||||||||||||||
572 | 423 | 268 | 287 | 124 | 125 | 109 | 109 | 113 | 100 | 73 | 46 | 14 | 0 | 0 | 0 | 0 | - | - | - | - |
Amortization/accretion on investments | ||||||||||||||||||||
0 | 4 | 39 | 73 | 55 | 18 | -60 | -136 | -160 | -202 | -245 | -304 | -390 | -315 | 0 | 0 | 0 | - | - | - | - |
Deferred tax | ||||||||||||||||||||
- | - | - | - | - | -37 | -6 | 20 | 20 | 37 | 0 | 0 | 0 | - | - | - | - | - | - | - | - |
Changes in operating assets and liabilities: | ||||||||||||||||||||
Accounts receivable | ||||||||||||||||||||
-4,699 | -2,070 | -1,184 | -834 | 1,051 | -28 | -971 | 114 | -1,227 | -1,490 | -1,290 | -1,216 | -266 | -4 | 6,009 | 2,433 | 4,061 | 6,107 | 0 | 0 | 0 |
Royalty receivable | ||||||||||||||||||||
2 | 20 | -10,464 | -32 | -52 | -55 | 0 | 0 | 0 | - | - | - | - | - | - | - | - | - | - | - | - |
Inventories | ||||||||||||||||||||
2,296 | 2,539 | 1,498 | 1,578 | 1,382 | 350 | -517 | -2,723 | -3,203 | -2,535 | -1,178 | -193 | -536 | 200 | 1,090 | 2,598 | 2,880 | 3,829 | 0 | 0 | 0 |
Prepaid expenses and other assets | ||||||||||||||||||||
602 | 1,623 | 141 | 2 | -445 | -529 | -682 | -571 | -691 | -1,770 | 258 | 773 | 1,011 | 1,550 | -136 | 168 | -1,067 | 1,045 | 0 | 0 | 0 |
Accounts payable, accrued expenses and other liabilities | ||||||||||||||||||||
-598 | 1,615 | 110 | -3,663 | -1,517 | -1,045 | -217 | 1,351 | -1,281 | -1,406 | 1,961 | 4,203 | 1,420 | 1,437 | -2,165 | -5,442 | 82 | 1,969 | 0 | 0 | 0 |
Advance on research and development | ||||||||||||||||||||
0 | - | - | - | 0 | - | - | - | 0 | - | - | - | - | - | - | - | - | - | - | - | - |
Deferred royalty revenue | ||||||||||||||||||||
- | - | - | - | - | - | - | - | - | - | - | 0 | -305 | - | -306 | -305 | 4,856 | 4,932 | 0 | 0 | 0 |
Other long-term liabilities | ||||||||||||||||||||
- | - | - | - | - | - | - | - | 488 | 487 | 486 | 284 | -39 | -56 | -74 | -79 | -22 | -51 | 0 | 0 | 0 |
Net cash used in operating activities | ||||||||||||||||||||
-3,078 | -2,838 | 3,580 | -15,609 | -21,414 | -25,176 | 0 | 0 | 0 | - | - | - | - | - | - | - | - | - | - | - | - |
Net cash used in operating activities | ||||||||||||||||||||
- | - | - | - | - | - | - | - | - | - | - | -43,149 | -49,147 | -49,132 | -57,791 | -60,033 | -52,062 | -54,450 | 0 | 0 | 0 |
Cash flows from investing activities: | ||||||||||||||||||||
Acquisition of property and equipment | ||||||||||||||||||||
3,646 | 2,926 | 3,215 | 3,015 | 3,516 | 4,059 | 4,065 | 4,543 | 5,077 | 5,233 | 4,986 | 6,005 | 5,319 | 7,161 | 7,266 | 5,854 | 6,526 | 4,643 | 0 | 0 | 0 |
(Increase) decrease in restricted cash | ||||||||||||||||||||
- | - | - | - | - | - | - | - | - | 162 | 162 | 462 | 162 | -300 | -420 | -4,028 | -3,781 | -3,837 | 0 | 0 | 0 |
Purchase of short term investment | ||||||||||||||||||||
- | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | 0 | - | - | - | 0 |
Purchase of investments | ||||||||||||||||||||
- | - | - | - | - | 27,430 | 27,438 | 24,700 | 20,665 | 30,991 | 0 | 0 | 0 | - | - | - | - | - | - | - | - |
Maturity of investments | ||||||||||||||||||||
0 | 7,250 | 23,270 | 30,770 | 43,470 | 47,115 | 40,095 | 39,095 | 33,395 | 32,125 | 43,675 | 48,175 | 46,675 | 37,050 | 0 | 0 | 0 | - | - | - | - |
Net cash (used in) provided by investing activities | ||||||||||||||||||||
-3,646 | 4,324 | 12,074 | 14,521 | 15,768 | 15,626 | 0 | 0 | 0 | - | - | - | - | - | - | - | - | - | - | - | - |
Net cash provided/(used) in investing activities | ||||||||||||||||||||
- | - | - | - | - | - | - | - | - | - | - | 10,970 | -11,051 | -35,425 | -47,905 | -51,689 | -29,684 | -806 | 0 | 0 | 0 |
Cash flows from financing activities: | ||||||||||||||||||||
Proceeds from exercise of common stock options | ||||||||||||||||||||
- | - | - | - | - | - | - | - | - | 2,108 | 3,976 | 4,441 | 5,195 | 4,087 | 2,458 | 2,078 | 1,505 | 806 | 0 | 0 | 0 |
Debt issuance costs | ||||||||||||||||||||
- | - | - | - | - | - | - | - | - | 434 | 434 | 434 | 297 | 0 | 0 | 0 | 0 | - | - | - | - |
Proceeds from issuance of debt | ||||||||||||||||||||
- | - | - | - | - | - | - | - | - | 30,000 | 30,000 | 30,000 | 15,000 | 0 | 0 | 0 | 0 | - | - | - | - |
Payments on long-term debt | ||||||||||||||||||||
- | - | - | - | - | - | - | - | - | - | - | - | - | 485 | 295 | 10,288 | 10,282 | 10,278 | 0 | 0 | 0 |
Net proceeds from issuance of common stock | ||||||||||||||||||||
6,140 | 4,999 | 3,944 | 4,444 | 1,444 | 22,768 | 21,824 | 21,324 | 22,347 | 1,023 | 0 | 0 | 0 | - | - | - | - | - | - | - | - |
Net cash provided by financing activities | ||||||||||||||||||||
9,668 | 8,527 | -7,816 | -7,430 | -13,669 | 7,655 | 0 | 0 | 0 | - | - | - | - | - | - | - | - | - | - | - | - |
Foreign exchange effect on cash and cash equivalents | ||||||||||||||||||||
-42 | 1 | -90 | 55 | -147 | -73 | 0 | 0 | 0 | - | - | - | - | - | - | - | - | - | - | - | - |
(Decrease) increase in cash, cash equivalents and restricted cash | ||||||||||||||||||||
2,902 | 10,014 | 7,748 | -8,463 | -19,462 | -1,968 | 0 | 0 | 0 | - | - | - | - | - | - | - | - | - | - | - | - |
Net cash provided by financing activities | ||||||||||||||||||||
- | - | - | - | - | - | - | - | - | - | - | 34,692 | 19,485 | 3,602 | 1,958 | 135,411 | 135,260 | 134,565 | 0 | 0 | 0 |
Foreign exchange effect on cash and cash equivalents | ||||||||||||||||||||
- | - | - | - | - | - | - | - | - | -3,709 | -1,959 | -1,119 | 522 | 1,027 | -478 | -372 | 130 | -24 | 0 | 0 | 0 |
Decrease in cash and cash equivalents | ||||||||||||||||||||
- | - | - | - | - | - | - | - | - | -18,909 | -8,439 | 1,394 | -40,191 | -79,928 | -104,216 | 23,317 | 53,644 | 79,285 | 0 | 0 | 0 |
Supplemental information: | ||||||||||||||||||||
Cash paid for income taxes | ||||||||||||||||||||
- | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | 0 | - | - | - | 0 |
Cash paid for interest | ||||||||||||||||||||
2,138 | 2,123 | 2,722 | 3,028 | 2,570 | 2,837 | 2,476 | 2,315 | 1,740 | 1,449 | 0 | 0 | 0 | - | - | - | 0 | - | - | - | 0 |
Noncash Investing and Financing Items [Abstract] | ||||||||||||||||||||
Operating leases right-of-use assets obtained in exchange for lease obligations | ||||||||||||||||||||
0 | - | 0 | 0 | 0 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - |