| Dec'19 | Dec'18 | Dec'17 | Dec'16 | Dec'15 | Dec'14 | Dec'13 | Dec'12 | Dec'11 | Dec'10 | Dec'09 |
|---|---|---|---|---|---|---|---|---|---|---|
Cash Flows From Operating Activities: | ||||||||||
Net Loss | ||||||||||
-50,878 | -151,184 | -93,031 | -128,530 | -127,197 | -118,080 | -81,550 | -59,123 | -44,799 | -2,533 | -36,525 |
Adjustments to Reconcile Net Loss to Net Cash Used in Operating Activities: | ||||||||||
Depreciation and Amortization | ||||||||||
4,858 | 3,577 | 4,414 | 3,095 | 2,998 | 2,388 | 1,932 | 2,047 | 2,248 | 2,718 | 2,583 |
Amortization of Intangible Assets | ||||||||||
- | 224 | 896 | 997 | 1,013 | 1,013 | 1,013 | 1,090 | 1,913 | 3,143 | 949 |
Amortization and Premium of Marketable Securities, Net | ||||||||||
1,140 | 1,048 | 290 | -926 | -350 | -95 | 1,366 | 660 | -17 | 14 | - |
Realized Gain on Sales and Maturities of Marketable Securities | ||||||||||
- | - | - | - | - | 11 | - | -6 | -5 | 4 | -24 |
Loss on Sale or Disposal of Assets | ||||||||||
-11 | -1,220 | -55 | -81 | - | -6 | 21 | 74 | 58 | 38 | 556 |
Goodwill Impairment | ||||||||||
- | 90,976 | - | - | - | - | - | - | - | - | - |
Intangible Asset Impairment | ||||||||||
- | 18,677 | 13,000 | - | - | - | - | - | - | - | - |
Other Asset Impairment | ||||||||||
1,800 | - | - | - | - | - | - | - | - | - | - |
Gain on Fair Value Remeasurement of Contingent Consideration | ||||||||||
1,294 | 29,621 | 800 | - | - | - | - | - | - | - | - |
Non-Cash Income Tax Benefit | ||||||||||
- | -765 | -24,282 | - | - | - | - | - | - | - | - |
Stock-Based Compensation Expense | ||||||||||
4,551 | 8,081 | 12,312 | 15,317 | 12,774 | 6,852 | 4,548 | 2,298 | 2,342 | 2,802 | 3,058 |
Non-Cash Expense | ||||||||||
- | - | - | 1,638 | 288 | 72 | 97 | 226 | 307 | 728 | 181 |
Changes in Operating Assets and Liabilities: | ||||||||||
Non-Cash Tax Benefit | ||||||||||
- | - | - | - | - | - | - | - | - | - | -529 |
Accounts and Other Receivables | ||||||||||
-2,274 | 777 | 96 | 814 | 543 | -62 | 445 | -126 | -154 | -220 | -1,283 |
Prepaid and Other Current Assets | ||||||||||
-362 | -1,783 | -793 | -1,320 | 653 | 2,026 | 706 | -33 | -241 | 546 | -743 |
Other Assets | ||||||||||
39 | - | -205 | 89 | -6 | -65 | -276 | 95 | -34 | -5,592 | -722 |
Accounts Payable and Accrued Expenses | ||||||||||
-321 | -13,110 | -8,744 | -4,970 | 4,875 | 1,450 | 7,236 | 3,762 | 2,076 | -1,193 | -2,463 |
Deferred Revenue | ||||||||||
- | - | - | - | - | - | - | - | - | -39,382 | -2,038 |
Other Liabilities | ||||||||||
-6,599 | -3,268 | -4,363 | -2,007 | 7,202 | 6,577 | 1,317 | 594 | -138 | -1,865 | 2,699 |
Net Cash Used in Operating Activities | ||||||||||
-46,415 | -75,235 | -99,931 | -113,036 | -98,887 | - | - | - | - | - | - |
Net Cash Used in Operating Activities | ||||||||||
- | - | - | - | - | -101,537 | -67,669 | -49,782 | -35,658 | -30,372 | -29,869 |
Cash Flows From Investing Activities: | ||||||||||
Sales and Maturities of Marketable Securities | ||||||||||
113,173 | 201,469 | 219,236 | 242,792 | 161,090 | 109,232 | 38,894 | 52,360 | 51,003 | 42,383 | 2,674 |
Purchases of Marketable Securities | ||||||||||
95,382 | 171,182 | 170,980 | 173,925 | 206,405 | 148,314 | 112,118 | 69,255 | 52,717 | 56,522 | 9,559 |
Investment in Other | ||||||||||
- | - | - | 1,801 | - | - | - | - | - | - | - |
Cash Acquired in Kolltan Acquisition, Net | ||||||||||
- | - | - | 4,592 | - | - | - | - | - | - | 51,654 |
Acquisition of Property and Equipment | ||||||||||
731 | 813 | 1,788 | 2,751 | 4,876 | 1,929 | 4,219 | 303 | 509 | 2,100 | 528 |
Proceeds from Sale or Disposal of Assets | ||||||||||
20 | 342 | - | - | - | - | 21 | 218 | 68 | 77 | 850 |
Net Cash Provided by Investing Activities | ||||||||||
17,080 | 29,816 | 46,468 | 68,907 | -50,191 | - | - | - | - | - | - |
Net Cash Provided by Investing Activities | ||||||||||
- | - | - | - | - | -41,011 | -77,422 | -16,980 | -2,155 | -16,162 | 45,091 |
Cash Flows From Financing Activities: | ||||||||||
Net Proceeds from Stock Issuances | ||||||||||
16,248 | 29,022 | 51,025 | 13,946 | 188,840 | - | 295,697 | 83,784 | 36,023 | 1,014 | 668 |
Proceeds from Issuance of Stock from Employee Benefit Plans | ||||||||||
9 | 419 | 265 | 536 | 4,311 | 1,171 | 5,403 | - | - | - | - |
Net Cash Provided by Financing Activities | ||||||||||
16,257 | 29,441 | 51,290 | 14,482 | 193,151 | - | - | - | - | - | - |
Payments of Term Loan | ||||||||||
- | - | - | - | - | - | 11,029 | 3,971 | - | - | - |
Related Party Loan Due to Medarex | ||||||||||
- | - | - | - | - | - | - | - | - | - | 2,957 |
(Payments) Issuance of Term Loan | ||||||||||
- | - | - | - | - | - | - | - | 5,000 | 10,000 | - |
Payment of Convertible Subordinated Debt | ||||||||||
- | - | - | - | - | - | - | - | 12,503 | - | - |
Payments of Other Liabilities | ||||||||||
- | - | - | - | - | - | 472 | 55 | 86 | 197 | 176 |
Net Cash Provided by Financing Activities | ||||||||||
- | - | - | - | - | 1,171 | 289,599 | 79,758 | 28,434 | 10,817 | -2,465 |
Effect of Exchange Rate Changes on Cash and Cash Equivalents | ||||||||||
- | - | - | - | 15 | -5 | -3 | 2 | -9 | 2 | -12 |
Net Decrease in Cash and Cash Equivalents | ||||||||||
-13,078 | -15,978 | -2,173 | -29,647 | 44,088 | -141,382 | 144,505 | - | - | - | - |
Net Increase (Decrease) in Cash and Cash Equivalents | ||||||||||
- | - | - | - | - | - | - | 12,998 | -9,388 | -35,715 | 12,745 |
Shares Issued to Executive Officers | ||||||||||
- | - | - | - | - | - | - | - | - | - | 250 |
Cash Paid for Interest | ||||||||||
- | - | - | - | - | - | 1,209 | 1,384 | 1,560 | 604 | 157 |
Non-cash Investing Activities | ||||||||||
Accrued construction in progress | ||||||||||
25 | 107 | 20 | 159 | 75 | 1,027 | - | - | - | - | - |
Non-cash Supplemental Disclosure | ||||||||||
Shares issued to former Kolltan executive for settlement of severance | ||||||||||
- | 71 | 344 | 426 | - | - | - | - | - | - | - |
Shares issued in connection with Kolltan Acquisition | ||||||||||
- | - | - | 73,397 | - | - | - | - | - | - | - |