| Dec'19 | Dec'18 | Dec'17 | Dec'16 | Dec'15 | Dec'14 | Dec'13 | Dec'12 | Dec'11 | Dec'10 |
|---|---|---|---|---|---|---|---|---|---|
Revenues: | |||||||||
Product revenue | |||||||||
143,006 | 95,388 | 55,511 | 78 | - | 13,625 | - | - | - | - |
Product revenue, net | |||||||||
- | - | - | - | 0 | 0 | - | - | 0 | 0 |
License and milestone revenue | |||||||||
- | - | - | - | - | 13,625 | - | - | - | - |
Operating expenses: | |||||||||
Research and development | |||||||||
283,146 | 231,347 | 142,498 | 251,129 | 269,251 | 137,705 | 66,545 | 58,894 | 40,726 | 22,323 |
Selling, general and administrative | |||||||||
182,769 | 175,781 | 138,907 | 40,731 | 30,524 | 21,457 | 16,567 | 10,638 | 6,860 | 4,302 |
Acquired in-process research and development | |||||||||
9,440 | - | - | 1,300 | 12,000 | 8,806 | 250 | 4,250 | 7,000 | 12,000 |
Other operating expenses | |||||||||
9,711 | - | - | - | - | - | - | - | - | - |
Impairment of intangible asset | |||||||||
- | - | - | 104,517 | 89,557 | 3,409 | - | - | - | - |
Change in fair value of contingent purchase consideration | |||||||||
- | - | - | 24,936 | 24,611 | -707 | -405 | - | - | - |
Total expenses | |||||||||
519,752 | 429,202 | 293,142 | 372,811 | 376,721 | 172,084 | 83,767 | 73,782 | 54,586 | - |
Operating loss | |||||||||
-376,746 | -333,814 | -237,631 | -372,733 | -376,721 | -158,459 | -83,767 | -73,782 | -54,586 | -38,625 |
Other income (expense): | |||||||||
Interest expense | |||||||||
19,405 | 13,183 | 10,428 | 8,491 | 8,372 | 2,604 | - | - | - | - |
Foreign currency loss | |||||||||
-547 | -346 | -82 | -580 | 2,740 | 3,580 | -535 | -65 | - | - |
Legal settlement loss | |||||||||
-26,750 | -27,975 | -105,500 | - | 0 | - | - | - | - | - |
Gain on extinguishment of debt | |||||||||
18,480 | - | - | - | - | - | - | - | - | - |
Other income | |||||||||
6,342 | 7,917 | 3,643 | 633 | 416 | -240 | -178 | 163 | -957 | 795 |
Other income (expense), net | |||||||||
-21,880 | -33,587 | -112,344 | -8,438 | -5,216 | 736 | -713 | -228 | - | - |
Loss before income taxes | |||||||||
-398,626 | -367,401 | -349,975 | -381,171 | -381,937 | -157,723 | -84,480 | -74,010 | -55,543 | -37,830 |
Income tax benefit | |||||||||
1,798 | 608 | -3,578 | -32,034 | -29,076 | 2,308 | 52 | -27 | 27 | - |
Net loss | |||||||||
-400,424 | -368,009 | -346,397 | -349,137 | -352,861 | -160,031 | -84,532 | -73,983 | -55,570 | -37,830 |
Other comprehensive income (loss): | |||||||||
Foreign currency translation adjustments, net of tax | |||||||||
-272 | -2,543 | 5,517 | -357 | -22,629 | - | - | - | - | - |
Net unrealized gain on available-for-sale securities, net of tax | |||||||||
41 | 82 | -110 | 237 | -383 | - | - | - | - | - |
Other comprehensive (loss) income: | |||||||||
-231 | -2,461 | 5,407 | -120 | -23,012 | - | - | - | - | - |
Comprehensive loss | |||||||||
-400,655 | -370,470 | -340,990 | -349,257 | -375,873 | - | - | - | - | - |
Loss per basic and diluted common share: | |||||||||
Basic and diluted net loss per common share | |||||||||
-7.43 | -7.07 | -7.36 | -9.07 | -9.79 | -4.72 | -2.95 | -2.97 | -14.42 | -28.55 |
Basic and diluted weighted average common shares outstanding | |||||||||
53,873 | 52,066 | 47,047 | 38,478 | 36,026 | 33,889 | 28,672 | 24,915 | 3,854 | 1,325 |
Product | |||||||||
Product revenue | |||||||||
143,000 | 95,400 | - | - | - | - | - | - | - | - |
Cost of sales | |||||||||
29,926 | 19,444 | 10,251 | 70 | 0 | 0 | - | - | - | - |
Intangible assets amortization | |||||||||
Cost of sales | |||||||||
4,760 | 2,630 | 1,486 | - | 0 | - | - | - | - | - |