| Dec'19 | Dec'18 | Dec'17 | Dec'16 | Dec'15 | Dec'14 | Dec'13 | Dec'12 | Dec'11 |
|---|---|---|---|---|---|---|---|---|
Cash flows from operating activities: | ||||||||
Net loss | ||||||||
-112,576 | -69,474 | -70,984 | -76,390 | -117,372 | -59,312 | -36,445 | -4,406 | -25,589 |
Adjustments to reconcile net loss to net cash used in operating activities: | ||||||||
Depreciation of property and equipment | ||||||||
564 | 860 | 1,091 | 1,063 | 657 | 283 | 258 | 280 | 270 |
Amortization of debt costs | ||||||||
- | - | - | - | 64 | 148 | 248 | 238 | 50 |
Amortization of discount/premium on investments | ||||||||
1,842 | 852 | 5 | -1,223 | -1,622 | -1,175 | -196 | -84 | -118 |
Share-based compensation | ||||||||
9,528 | 13,074 | 16,110 | 16,223 | 12,959 | 4,411 | 3,071 | 1,396 | 1,055 |
Fair value of common stock issued for license agreement | ||||||||
34,900 | 0 | 0 | - | - | - | - | - | - |
Amortization of deferred lease obligations | ||||||||
- | - | - | - | - | - | 10 | 0 | - |
Loss on disposition of assets | ||||||||
-264 | -5 | -10 | - | - | - | -4 | 0 | - |
Loss on sale of investments | ||||||||
-31 | -378 | 0 | 0 | - | - | - | - | - |
Unrealized loss on equity investment | ||||||||
0 | 348 | - | - | - | - | - | - | - |
Unrealized loss on equity investment | ||||||||
- | - | 1,160 | 0 | 0 | - | - | - | - |
Lease-related amortization | ||||||||
-76 | -59 | -319 | 132 | 19 | -19 | - | - | - |
Fair value adjustments to preferred stock warrant liability | ||||||||
- | - | - | - | - | - | 6,590 | 847 | - |
Deferred lease obligation | ||||||||
- | - | - | - | - | - | - | - | -4 |
Fair value measurement of redeemable convertible preferred stock warrant liability | ||||||||
- | - | - | - | - | - | - | - | 385 |
Changes in operating assets and liabilities: | ||||||||
Accounts receivable | ||||||||
903 | -1,352 | 83 | -861 | 2,354 | -142 | -535 | -3,404 | 4,187 |
Prepaid expenses and other assets | ||||||||
777 | -638 | 178 | -3,215 | 3,028 | 107 | 1,790 | -65 | 442 |
Accounts payable and accrued liabilities | ||||||||
-4,294 | 5 | 3,073 | -10,142 | 7,725 | 6,202 | 1,764 | -3,784 | 2,065 |
Net cash used in operating activities | ||||||||
-75,181 | -53,725 | -50,125 | -63,815 | -99,708 | -47,077 | -25,559 | -1,876 | -26,279 |
Cash flows from investing activities: | ||||||||
Purchases of property and equipment | ||||||||
158 | 181 | 151 | 841 | 2,393 | 1,018 | 193 | 126 | 321 |
Purchases of short-term investments | ||||||||
167,528 | 125,611 | 0 | 23,992 | 60,297 | 155,433 | 1,852 | 9,907 | 13,640 |
Purchases of long-term investments | ||||||||
0 | 6,031 | 162,613 | 79,381 | 234,791 | 55,337 | 0 | 0 | - |
Proceeds from sales of short-term investments | ||||||||
13,117 | 111,178 | 13,500 | 0 | 1,003 | 3,499 | 750 | 0 | 500 |
Proceeds from maturities of short-term investments | ||||||||
165,200 | 125,740 | 165,695 | 198,279 | 126,742 | 48,589 | 10,757 | 5,894 | 7,100 |
Proceeds from maturities of long-term investments | ||||||||
- | - | - | - | 240 | 0 | 0 | - | - |
Repayment of loan to officer | ||||||||
- | - | - | - | - | - | - | - | 125 |
Net cash provided by (used in) investing activities | ||||||||
10,631 | 105,095 | 16,431 | 94,065 | -169,496 | -159,700 | 9,462 | -4,139 | -6,236 |
Cash flows from financing activities: | ||||||||
Proceeds from issuance of redeemable convertible preferred stock and warrants | ||||||||
- | - | - | - | - | - | - | - | 45,000 |
Proceeds from exercise of stock options | ||||||||
43 | 115 | 121 | 168 | 2,107 | 4,593 | 1,946 | 14 | 30 |
Proceeds from employee stock purchase plan | ||||||||
325 | 608 | 712 | 440 | 1,048 | 426 | 0 | 0 | - |
Proceeds from exercise of warrants | ||||||||
- | - | - | - | 1,001 | 6 | 1,537 | 0 | - |
Proceeds from issuance of common stock, net of commissions | ||||||||
0 | 10,867 | 0 | 0 | 161,879 | 225,938 | 107,634 | - | - |
Payments of deferred offering costs | ||||||||
23 | 402 | 54 | 0 | 0 | - | - | - | - |
Payments for deferred financing costs | ||||||||
- | - | - | - | -338 | 0 | 0 | - | - |
Proceeds from issuance of debt | ||||||||
- | - | - | - | - | - | - | 15,000 | - |
Proceeds from public offerings, net of offering costs | ||||||||
- | - | - | - | - | - | - | 0 | - |
Debt discount | ||||||||
- | - | - | - | - | - | - | -75 | - |
Repayments of debt | ||||||||
- | - | - | - | 4,350 | 5,700 | 4,950 | 2,601 | - |
Payments for stock offering and deferred financing costs | ||||||||
- | - | - | - | - | - | - | 24 | - |
Repayment of loan payable | ||||||||
- | - | - | - | - | - | - | - | 1,965 |
Stock offering and deferred financing costs | ||||||||
- | - | - | - | - | - | - | - | 249 |
Net cash provided by financing activities | ||||||||
345 | 11,188 | 779 | 608 | 161,347 | 225,263 | 106,167 | 12,314 | 42,816 |
Net increase (decrease) in cash and cash equivalents | ||||||||
-64,205 | 62,558 | -32,915 | - | - | - | - | - | - |
Net (decrease) increase in cash and cash equivalents | ||||||||
- | - | - | 30,858 | -107,857 | 18,486 | 90,070 | 6,299 | 10,301 |
Supplemental disclosure of cash flow information | ||||||||
Cash paid for interest | ||||||||
- | - | - | - | 158 | 614 | 1,092 | 448 | 186 |
Non-cash addition to deferred offering costs | ||||||||
0 | 22 | 276 | 0 | 0 | - | - | - | - |
Non-cash acquisition of investment in U.S. corporation | ||||||||
- | - | - | - | - | 1,545 | 0 | 0 | - |