| Dec'19 | Dec'18 | Dec'17 | Dec'16 | Dec'15 | Dec'14 | Dec'13 | Dec'12 | Dec'11 | Dec'10 | Dec'09 |
|---|---|---|---|---|---|---|---|---|---|---|
Product revenue, net | ||||||||||
306,486 | 251,247 | 159,201 | 81,321 | 50,286 | 26,551 | 10,357 | 3,307 | - | - | - |
Collaboration revenue | ||||||||||
- | - | - | - | - | - | - | - | - | - | 29 |
Operating expenses: | ||||||||||
Cost of sales | ||||||||||
5,504 | 5,215 | 3,554 | 2,058 | 1,361 | 882 | 143 | 91 | - | - | - |
Research and development | ||||||||||
89,017 | 75,247 | 40,376 | 23,844 | 15,419 | 18,372 | 20,470 | 14,074 | 21,001 | 18,949 | 14,402 |
Selling, general and administrative | ||||||||||
100,359 | 81,289 | 62,416 | 45,240 | 36,949 | 34,916 | 31,240 | 25,414 | 11,331 | 8,488 | 5,877 |
Total operating expenses | ||||||||||
194,880 | 161,751 | 106,346 | 71,142 | 53,729 | 54,170 | 51,853 | 39,579 | 32,332 | 27,437 | 20,279 |
Income from operations | ||||||||||
111,606 | 89,496 | 52,855 | 10,179 | -3,443 | -27,619 | -41,496 | -36,272 | -32,332 | -27,437 | -20,250 |
Interest and other income | ||||||||||
5,070 | 2,657 | -49 | -2,039 | -2,965 | 3,764 | 4,515 | 1,776 | 25 | 25 | 17 |
Interest and other income | ||||||||||
- | - | - | - | - | - | - | - | 3 | 1,496 | 101 |
Income before income taxes | ||||||||||
116,676 | 92,153 | 52,806 | 8,140 | -6,408 | - | - | - | - | - | - |
Income tax expense | ||||||||||
22,495 | 16,743 | -76,316 | 0 | 0 | - | - | - | - | - | - |
Net income | ||||||||||
94,181 | 75,410 | 129,122 | 8,140 | -6,408 | -31,383 | -46,011 | -38,048 | -32,354 | -25,966 | -20,166 |
Other comprehensive income (loss): | ||||||||||
Net unrealized gain on available-for-sale investments, net of tax impact of $(20) and $(52), respectively | ||||||||||
327 | 5 | -75 | 0 | 0 | - | - | - | - | - | - |
Foreign currency translation loss, net of tax | ||||||||||
4 | - | - | - | - | - | - | - | - | - | - |
Total comprehensive income | ||||||||||
94,512 | 75,415 | 129,047 | 8,140 | -6,408 | - | - | - | - | - | - |
Basic net income per share (in dollars per share) | ||||||||||
0.82 | 0.65 | 1.14 | 0.07 | -0.06 | - | - | - | - | - | - |
Diluted net income per share (in dollars per share) | ||||||||||
0.77 | 0.60 | 1.04 | 0.07 | -0.06 | - | - | - | - | - | - |
Basic and diluted net income (loss) per common share | ||||||||||
- | - | - | - | - | -0.31 | -0.46 | -0.41 | -0.39 | -0.38 | -0.38 |
Weighted-average shares outstanding used in computing net income per share | ||||||||||
Basic (in shares) | ||||||||||
114,349 | 115,343 | 113,527 | 110,566 | 106,883 | 100,978 | - | - | - | - | - |
Diluted (in shares) | ||||||||||
122,566 | 126,688 | 124,515 | 116,139 | 106,883 | 100,978 | - | - | - | - | - |
Weighted average shares outstanding used in computing basic and diluted net loss per share | ||||||||||
- | - | - | - | - | - | 99,819 | 93,015 | 83,309 | 68,336 | 52,443 |