| Dec'19 | Dec'18 | Dec'17 | Dec'16 | Dec'15 | ||
|---|---|---|---|---|---|---|
Cash flows from operating activities | ||||||
Net loss | ||||||
-46,672 | -46,939 | -55,663 | -36,375 | -31,335 | ||
Adjustments to reconcile net loss to net cash used in operating activities: | ||||||
Depreciation and amortization | ||||||
743 | 847 | 842 | 594 | 148 | ||
Accretion related to marketable securities | ||||||
-644 | -608 | -195 | 648 | -41 | ||
Stock-based compensation | ||||||
7,348 | 7,135 | 6,229 | 3,828 | 428 | ||
Change in fair value of convertible preferred stock liability | ||||||
- | - | - | - | 17,600 | ||
Other | ||||||
- | - | - | - | -40 | ||
Changes in operating assets and liabilities: | ||||||
Prepaid and other current assets | ||||||
370 | -187 | 44 | -290 | 1,265 | ||
Operating lease right-of-use asset | ||||||
-599 | - | - | - | - | ||
Other assets | ||||||
50 | -406 | - | 869 | - | ||
Accounts payable | ||||||
450 | -1,456 | 1,554 | 518 | 1,240 | ||
Accrued and other liabilities | ||||||
2,030 | -458 | 1,499 | 2,814 | 1,218 | ||
Operating lease liability | ||||||
-767 | - | - | - | - | ||
Other long-term liabilities | ||||||
12 | -102 | -434 | 695 | 639 | ||
Net cash used in operating activities | ||||||
-37,321 | -40,988 | -46,212 | -27,857 | -11,328 | ||
Cash flows from investing activities | ||||||
Purchases of marketable securities | ||||||
138,586 | 161,861 | 88,309 | 258,281 | - | ||
Sales of marketable securities | ||||||
- | - | - | 4,199 | - | ||
Purchases of marketable securities | ||||||
- | - | - | - | 104,385 | ||
Maturities of marketable securities | ||||||
141,866 | 132,024 | 173,401 | 213,725 | 14,100 | ||
Purchases of property and equipment | ||||||
25 | 355 | 266 | 2,199 | 1,747 | ||
Net cash provided by investing activities | ||||||
3,255 | -30,192 | 84,826 | -42,556 | -92,032 | ||
Cash flows from financing activities | ||||||
Proceeds from issuance of common stock, net (includes $30,850 in aggregate gross proceeds from related parties for the year ended December 31, 2018) | ||||||
- | 64,877 | 711 | 71,354 | - | ||
Proceeds from issuance of convertible preferred stock, net | ||||||
- | - | - | - | 95,569 | ||
Payment of offering costs | ||||||
- | - | - | - | 729 | ||
Proceeds from exercise of common stock options | ||||||
24 | 393 | 731 | 4 | 108 | ||
Net cash provided by financing activities | ||||||
24 | 65,270 | 1,442 | 71,358 | 94,948 | ||
Net increase (decrease) in cash and cash equivalents | ||||||
-34,042 | -5,910 | 40,056 | 945 | - | ||
Net increase in cash and cash equivalents | ||||||
- | - | - | - | -8,412 | ||
Supplemental disclosures of cash flow information | ||||||
Purchases of property and equipment incurred but not paid | ||||||
- | 84 | - | 84 | 286 | ||
Deferred offering costs incurred but not paid | ||||||
- | - | - | - | 222 | ||