| Mar'20 | Dec'19 | Sep'19 | Jun'19 | Mar'19 | Dec'18 | Sep'18 | Jun'18 | Mar'18 | Dec'17 | Sep'17 | Jun'17 | Mar'17 | Dec'16 | Sep'16 | Jun'16 | Mar'16 | Dec'15 | Sep'15 | Jun'15 | Mar'15 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Operating expenses: | ||||||||||||||||||||
Research and development | ||||||||||||||||||||
38,719 | 37,975 | 37,449 | 36,827 | 35,902 | 38,586 | 39,881 | 42,240 | 44,911 | 46,305 | 45,749 | 42,723 | 37,456 | 29,356 | 25,132 | 19,939 | 14,825 | 11,352 | 0 | 0 | 0 |
General and administrative | ||||||||||||||||||||
11,099 | 10,879 | 11,136 | 11,394 | 10,981 | 10,636 | 10,359 | 9,795 | 10,040 | 10,219 | 9,835 | 10,393 | 9,311 | 7,620 | 6,699 | 4,536 | 3,157 | 2,418 | 0 | 0 | 0 |
Total operating expenses | ||||||||||||||||||||
- | - | - | - | - | - | - | - | - | - | - | - | 0 | - | 0 | 0 | 0 | - | 0 | - | - |
Total operating expenses | ||||||||||||||||||||
49,818 | 48,854 | 48,585 | 48,221 | 46,883 | 49,222 | 50,995 | 55,020 | 0 | - | 0 | 0 | - | - | - | - | - | - | - | 0 | 0 |
Loss from operations | ||||||||||||||||||||
-49,818 | -48,854 | -48,585 | -48,221 | -46,883 | -49,222 | -50,240 | -52,035 | -54,951 | -56,524 | -55,584 | -53,116 | -46,767 | -36,976 | -31,831 | -24,475 | -17,982 | -13,770 | 0 | 0 | 0 |
Change in fair value of convertible preferred stock liability | ||||||||||||||||||||
- | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | 17,600 | 0 | 0 | 0 |
Interest income and other expense, net | ||||||||||||||||||||
1,854 | 2,182 | 2,451 | 2,593 | 2,602 | 2,283 | 1,848 | 1,390 | 0 | - | 0 | 0 | - | - | - | - | - | - | 0 | - | - |
Interest income | ||||||||||||||||||||
- | - | - | - | - | - | - | - | - | - | - | - | 0 | - | 0 | 0 | 0 | - | - | 0 | 0 |
Net loss | ||||||||||||||||||||
-47,964 | -46,672 | -46,134 | -45,628 | -44,281 | -46,939 | -48,359 | -50,578 | -53,928 | -55,663 | -54,820 | -52,400 | -46,064 | -36,375 | -31,328 | -24,182 | -35,769 | -31,335 | 0 | 0 | 0 |
Net loss per share, basic and diluted (in dollars per share) | ||||||||||||||||||||
-0.44 | -0.38 | -0.37 | -0.44 | -0.40 | -0.32 | -0.36 | -0.40 | -0.63 | -0.58 | -0.62 | -0.73 | -0.79 | 3.97 | -0.51 | -0.43 | -5.39 | -11.03 | -7.97 | -58.42 | -6.44 |
Shares used to compute net loss per share, basic and diluted (in shares) | ||||||||||||||||||||
29,411 | 29,408 | 29,389 | 29,309 | 29,292 | 29,392 | 29,087 | 28,979 | 22,580 | 20,676 | 20,501 | 20,426 | 20,349 | 20,368 | 20,183 | 19,959 | 1,176 | 455 | 395 | 346 | 297 |
Other comprehensive loss: | ||||||||||||||||||||
Unrealized gain on marketable securities | ||||||||||||||||||||
32 | 63 | 73 | 63 | 54 | 7 | -26 | 27 | 19 | -2 | -55 | -129 | -91 | 6 | 88 | 0 | 0 | - | 0 | - | - |
Total other comprehensive income (loss) | ||||||||||||||||||||
- | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | 0 | - | - |
Comprehensive loss | ||||||||||||||||||||
-47,932 | -46,609 | -46,061 | -45,565 | -44,227 | -46,932 | -48,385 | -50,551 | -53,909 | -55,665 | -54,875 | -52,529 | -46,155 | -36,369 | -31,287 | -24,104 | -35,740 | -31,380 | 0 | 0 | 0 |