| Dec'19 | Dec'18 | Dec'17 | Dec'16 | Dec'15 | Dec'14 | Dec'13 | Dec'12 | Dec'11 | Dec'10 | Dec'09 |
|---|---|---|---|---|---|---|---|---|---|---|
Revenues: | ||||||||||
License and contract revenues | ||||||||||
3,345 | 26,290 | 25,146 | - | - | - | - | - | - | - | - |
Product sales, net | ||||||||||
- | - | - | 4,127 | 3,472 | 6,917 | 2,314 | 0 | - | - | - |
License and contract revenue | ||||||||||
- | - | - | 53,278 | 12,644 | 53,160 | 32,364 | 0 | - | - | - |
License and contract revenue | ||||||||||
- | - | - | - | - | - | - | - | - | 319 | 80 |
Total revenues | ||||||||||
- | - | - | 57,405 | 16,116 | 60,077 | 34,678 | 0 | - | 319 | 80 |
Operating costs and expenses: | ||||||||||
Cost of product sold | ||||||||||
- | - | 364 | - | - | - | - | - | - | - | - |
Cost of product sold | ||||||||||
- | - | - | 1,377 | 1,940 | 895 | 137 | 0 | - | - | - |
Research and development | ||||||||||
24,107 | 36,467 | 32,866 | 64,961 | 76,627 | 64,596 | 33,624 | 33,201 | 34,900 | 27,031 | - |
Research and development | ||||||||||
- | - | - | - | - | - | - | - | - | - | 30,179 |
General and administrative | ||||||||||
19,155 | 22,062 | 31,435 | 45,306 | 53,962 | 56,241 | 42,443 | 38,244 | 38,290 | 51,546 | 57,725 |
Settlement expense | ||||||||||
- | - | - | - | - | - | - | - | 11,000 | -145 | - |
Restructuring expenses | ||||||||||
794 | 660 | 0 | - | - | - | - | - | - | - | 3,979 |
Acquired in-process research and development | ||||||||||
- | - | - | - | - | 21,859 | 0 | 29,108 | - | - | - |
Other operating income | ||||||||||
- | - | - | 5,077 | -253 | -2,719 | - | - | - | - | - |
Settlement expense | ||||||||||
- | - | - | - | - | - | - | 944 | - | - | - |
Other operating expenses | ||||||||||
- | - | - | - | - | - | 0 | 0 | - | - | - |
Gain on sale of investment in joint venture | ||||||||||
- | - | - | - | - | - | - | - | - | - | 10,244 |
Total operating costs and expenses | ||||||||||
44,056 | 59,189 | 64,665 | 106,567 | 132,782 | 146,310 | 76,204 | 101,497 | 62,190 | 78,722 | 81,639 |
Loss from operations | ||||||||||
-40,711 | -32,899 | -39,519 | -49,162 | -116,666 | -86,233 | -41,526 | -101,497 | -62,190 | -78,403 | -81,559 |
Non-operating income (expense): | ||||||||||
Interest income | ||||||||||
1,172 | 1,219 | 0 | - | - | - | - | - | - | - | - |
Investment and other income (expense), net | ||||||||||
- | - | - | - | - | - | - | - | 1,545 | 1,095 | 133 |
Interest expense | ||||||||||
1,002 | 1,209 | 1,872 | 2,614 | 2,104 | 1,947 | 1,026 | 56 | 870 | 2,208 | 4,806 |
Amortization of debt discount and issuance costs | ||||||||||
521 | 525 | 163 | 214 | 390 | 729 | 513 | 0 | 546 | 768 | 5,788 |
Foreign exchange loss | ||||||||||
-281 | -233 | 817 | -484 | -703 | -4,435 | 61 | 344 | -558 | -521 | 33 |
Other non-operating income | ||||||||||
1,320 | 4,295 | -94 | -479 | -900 | -885 | -546 | -478 | - | - | - |
Make-whole interest expense | ||||||||||
- | - | - | - | - | - | - | - | - | - | 6,345 |
Gain on derivative liabilities, net | ||||||||||
- | - | - | - | - | - | - | - | - | - | 7,218 |
Gain on exchange of convertible notes | ||||||||||
- | - | - | - | - | - | - | - | - | - | 7,381 |
Equity loss from investment in joint venture | ||||||||||
- | - | - | - | - | - | - | - | - | - | -1,204 |
Other expense | ||||||||||
- | - | - | - | - | - | - | - | - | - | 6,000 |
Debt conversion expense | ||||||||||
- | - | - | - | - | - | - | - | - | 2,031 | - |
Settlement expense | ||||||||||
- | - | - | - | - | - | - | - | - | - | 4,710 |
Total non-operating expense, net | ||||||||||
688 | 3,547 | -1,312 | -3,791 | -4,097 | -7,996 | -2,024 | -190 | -429 | -4,433 | -14,088 |
Net loss before noncontrolling interest | ||||||||||
-40,023 | -29,352 | -40,831 | -52,953 | -120,763 | -94,229 | -43,550 | -101,687 | -62,619 | -82,836 | - |
Net loss before noncontrolling interest | ||||||||||
- | - | - | - | - | - | - | - | - | - | -95,647 |
Noncontrolling interest | ||||||||||
-3 | -32 | -161 | -944 | -1,341 | -862 | -807 | -313 | -259 | -194 | -252 |
Net Income (Loss) Attributable to Parent | ||||||||||
-40,020 | -29,320 | -40,670 | -52,009 | -119,422 | -93,367 | -42,743 | -101,374 | -62,360 | -82,642 | -95,395 |
Gain on restructuring of preferred stock | ||||||||||
- | - | - | - | - | - | - | - | - | - | 2,116 |
Preferred Stock Dividends and Other Adjustments | ||||||||||
0 | 80 | 4,350 | 0 | 3,200 | 2,625 | 6,900 | 13,901 | 58,718 | 64,918 | 23,484 |
Net loss | ||||||||||
-40,020 | -29,400 | -45,020 | -52,009 | -122,622 | -95,992 | -49,643 | -115,275 | -121,078 | -147,560 | -116,763 |
Basic and diluted net loss per common share (in dollars per share) | ||||||||||
-0.69 | -0.52 | -1.24 | -1.86 | -6.51 | -6.46 | -0.43 | -1.98 | -3.53 | -6.47 | -1.53 |
Shares used in calculation of basic and diluted net loss per common share (in shares) | ||||||||||
57,974 | 56,073 | 36,445 | 27,948 | 18,837 | 14,853 | 114,195 | 58,125 | 34,294 | 22,821 | - |
Shares used in calculation of basic and diluted net loss per common share | ||||||||||
- | - | - | - | - | - | - | - | - | - | 76,393 |
Product sales, net | ||||||||||
Total revenues | ||||||||||
- | - | 853 | - | - | - | - | - | - | - | - |
License and contract revenue | ||||||||||
Total revenues | ||||||||||
- | - | 24,293 | - | - | - | - | - | - | - | - |