| Dec'19 | Dec'18 | Dec'17 | Dec'16 | Dec'15 | Dec'14 | Dec'13 |
|---|---|---|---|---|---|---|
Cash flows from operating activities: | ||||||
Net income (loss) | ||||||
-102,238 | -84,604 | -43,099 | - | - | - | - |
Net loss | ||||||
- | - | - | -58,900 | -35,374 | -30,310 | -15,143 |
Adjustments to reconcile net income (loss) to net cash used in operating activities: | ||||||
Loss/(gain) on disposal of property and equipment | ||||||
- | - | - | 47 | -25 | - | -26 |
Amortization of intangible assets | ||||||
146 | 146 | 146 | - | - | - | - |
Depreciation and amortization | ||||||
2,459 | 1,738 | 1,516 | - | - | - | - |
Depreciation and amortization | ||||||
- | - | - | 1,733 | 1,206 | 783 | 655 |
Amortization of debt discount | ||||||
- | - | - | - | 80 | 40 | 12 |
Accretion of discounts on investments | ||||||
2,228 | 1,701 | -371 | -1,662 | -1,186 | - | - |
Issuance of common stock in connection with a license agreement | ||||||
- | - | - | - | - | - | 198 |
Stock-based compensation expense | ||||||
19,100 | 16,878 | 11,287 | 10,095 | 3,986 | 553 | 343 |
Issuance of common stock in connection with UCSB sublicense fee | ||||||
1,602 | - | - | 159 | - | - | - |
Non-cash acquisition of in process research and development asset charged to expense | ||||||
- | - | 10,700 | - | - | - | - |
Deferred income taxes | ||||||
- | - | -513 | 6 | 8 | 8 | 10 |
Changes in operating assets and liabilities | ||||||
Accounts receivable | ||||||
-84 | -10,042 | 7,980 | 1,787 | -1,131 | 1,638 | 237 |
Related party accounts receivable | ||||||
- | - | -154 | -218 | - | - | - |
Prepaid expenses and other current assets | ||||||
-2,074 | 4,899 | 456 | 1,597 | 1,491 | 261 | 88 |
Other assets | ||||||
640 | 20 | -1,618 | 2,609 | -128 | 344 | 78 |
Accounts payable | ||||||
-374 | 261 | -2,441 | 1,765 | 2,944 | 660 | 366 |
Accrued liabilities, income tax payable and other long-term liabilities | ||||||
-12,724 | 24,833 | 9,157 | - | - | - | - |
Accrued liabilities and other liabilities | ||||||
- | - | - | 3,953 | 3,170 | 793 | - |
Deferred revenue | ||||||
-47,741 | -38,195 | 189,913 | 43,317 | - | - | - |
Accrued liabilities | ||||||
- | - | - | - | - | - | 495 |
Deferred revenue | ||||||
- | - | - | - | -6,130 | 61,463 | 5,500 |
Net cash used in operating activities | ||||||
-140,480 | -75,521 | 170,373 | -2,032 | - | - | - |
Cash flows from investing activities: | ||||||
Net cash used in operating activities | ||||||
- | - | - | - | -27,415 | 31,802 | -8,008 |
Purchases of property and equipment | ||||||
3,497 | 3,788 | 1,559 | 2,176 | 1,594 | 1,663 | 732 |
Proceeds from sales of assets | ||||||
- | - | - | 52 | - | - | - |
Purchases of short-term investments | ||||||
174,992 | 204,601 | 218,707 | 121,517 | - | - | - |
Maturities of short-term investments | ||||||
258,190 | 214,315 | 99,000 | 169,500 | - | - | - |
Purchases of short-term investments | ||||||
- | - | - | - | 250,901 | - | - |
Maturities of short-term investments | ||||||
- | - | - | - | 122,750 | - | - |
Net cash provided by (used in) investing activities | ||||||
79,701 | 5,926 | -121,266 | 45,859 | - | - | - |
Cash flows from financing activities: | ||||||
Proceeds from issuance of redeemable convertible preferred stock, net of issuance costs | ||||||
- | - | - | - | 74,430 | 26,802 | - |
Proceeds from issuance of common stock, net of issuance costs | ||||||
- | 134,596 | 19,957 | - | - | - | - |
Increase in restricted cash | ||||||
- | - | - | - | 817 | - | - |
Net cash used in investing activities | ||||||
- | - | - | - | -130,562 | -1,663 | -732 |
Proceeds from employee stock purchase plan and exercise of stock options | ||||||
1,627 | 5,028 | 3,839 | 930 | 263 | 8 | 62 |
Proceeds from stockholder notes | ||||||
- | - | - | 78 | - | - | - |
Proceeds from initial public offering, net of issuance costs | ||||||
- | - | - | - | 81,777 | - | - |
Repayment of notes payable | ||||||
- | - | - | - | -3,067 | -1,256 | 724 |
Proceeds from issuance of notes payable | ||||||
- | - | - | - | - | - | 3,359 |
Payment of deferred offering costs | ||||||
- | - | - | 12 | - | - | - |
Net cash provided by financing activities | ||||||
1,627 | 139,624 | 23,796 | 996 | - | - | - |
Net decrease in cash, cash equivalents and restricted cash | ||||||
-59,152 | 70,029 | 72,903 | 44,823 | - | - | - |
Net cash provided by financing activities | ||||||
- | - | - | - | 153,403 | 25,554 | 2,697 |
Net increase in cash, cash equivalents and restricted cash | ||||||
- | - | - | - | -4,574 | 55,693 | -6,043 |
Supplemental disclosures of cash flow information: | ||||||
Cash paid for income taxes | ||||||
13,061 | - | - | - | - | - | - |
Supplemental disclosures of noncash investing and financing items: | ||||||
Purchases of property and equipment in accounts payable and accrued liabilities | ||||||
428 | 1,027 | 361 | 473 | 100 | 68 | - |
Accretion to redemption value and cumulative dividends on preferred stock | ||||||
- | - | - | - | 6,705 | 4,566 | 3,751 |
Convertible preferred stock liability recorded in connection with redeemable convertible preferred stock | ||||||
- | - | - | - | 1,509 | 908 | - |
Stock issuance costs in accounts payable and accrued liabilities | ||||||
- | - | - | - | 13 | 284 | - |
Convertible preferred stock warrants issued in connection with debt | ||||||
- | - | - | - | - | - | 82 |
Issuance costs in accounts payable and accrued liabilities | ||||||
- | - | - | - | - | - | 198 |