| Dec'19 | Dec'18 | Dec'17 | Dec'16 | Dec'15 | Dec'14 | Dec'13 | Dec'12 | Dec'11 | Dec'10 | Dec'09 |
|---|---|---|---|---|---|---|---|---|---|---|
Revenues | ||||||||||
15 | 260 | 260 | - | - | - | - | - | - | - | - |
Revenues | ||||||||||
- | - | - | 16 | 10 | 18 | 110 | 407 | 390 | 733 | - |
Operating expenses: | ||||||||||
Research and development expenses | ||||||||||
4,061 | 3,960 | 8,096 | 13,155 | 12,637 | 8,361 | 7,285 | 6,105 | 7,354 | 9,163 | 5,346 |
General and administrative expenses | ||||||||||
4,585 | 4,559 | 5,471 | 7,497 | 6,529 | 9,093 | 5,348 | 4,247 | 5,839 | 6,623 | 5,030 |
Depreciation and amortization | ||||||||||
- | - | - | - | - | - | - | 211 | 187 | 130 | 88 |
Total operating expenses | ||||||||||
8,647 | 8,519 | 13,567 | 20,653 | 19,166 | 17,454 | 12,633 | 10,564 | 13,381 | 15,918 | 10,466 |
Operating loss | ||||||||||
-8,631 | -8,259 | -13,307 | -20,636 | -19,156 | -17,435 | -12,523 | -10,156 | -12,990 | -15,184 | -10,466 |
Other income (expense): | ||||||||||
Interest income | ||||||||||
67 | 78 | 70 | 58 | 69 | 67 | 68 | 34 | 60 | 59 | 19 |
Interest expense | ||||||||||
8 | 7 | 159 | 1,141 | 1,816 | 1,620 | 1,394 | 2 | 0 | 2 | 0 |
Gain (loss) on fair value of liability classified warrants | ||||||||||
499 | 3,269 | -1,470 | 660 | 0 | - | - | - | - | - | - |
Write-off of related party receivable and other income (expense) | ||||||||||
277 | 5 | - | - | - | - | - | - | - | - | - |
Gain on related party settlement | ||||||||||
- | - | - | 458 | 0 | - | - | - | - | - | - |
Fees related to issuance of liability classified warrants and other expenses | ||||||||||
- | - | 799 | 474 | 0 | - | - | - | - | - | - |
Warrant modification expense | ||||||||||
- | - | - | - | - | 3,109 | 5,017 | 0 | 0 | - | - |
Loss from change in fair value of derivative instruments | ||||||||||
- | - | - | - | - | 334 | 965 | 0 | -161 | - | - |
Loss on debt extinguisment | ||||||||||
- | - | - | - | - | -445 | 0 | 0 | - | - | - |
Other expense | ||||||||||
- | - | - | - | - | 0 | 0 | - | - | - | - |
Litigation settlement | ||||||||||
- | - | - | - | - | 250 | 0 | 3 | 250 | - | - |
Warrant issuance and modification expense | ||||||||||
- | - | - | - | - | - | - | - | - | 1,906 | - |
Gain from change in fair value of derivative instruments | ||||||||||
- | - | - | - | - | - | - | - | - | -1,352 | 83 |
Total other income (expense) | ||||||||||
280 | 3,334 | -2,358 | -437 | -1,747 | -5,192 | -7,307 | 34 | 471 | -3,202 | 102 |
Net loss | ||||||||||
-8,351 | -4,924 | -15,665 | -21,074 | -20,903 | -22,628 | -19,831 | -10,121 | -12,518 | -18,387 | -10,364 |
Net loss per share - basic and diluted (in dollars per share) | ||||||||||
-3.80 | -7.54 | -1.20 | -2.53 | -2.99 | -0.26 | -0.27 | -0.17 | -0.26 | -0.42 | -0.30 |
Weighted average common shares outstanding - basic and diluted (in shares) | ||||||||||
2,197 | 653 | 13,064 | 8,345 | 6,989 | 87,086 | 72,279 | 58,153 | 48,340 | - | - |
Comprehensive loss: | ||||||||||
Net loss | ||||||||||
-8,351 | -4,924 | -15,665 | -21,074 | -20,903 | -22,628 | -19,831 | -10,121 | -12,518 | -18,387 | -10,364 |
Foreign currency translation adjustment | ||||||||||
-5 | -3 | -1 | 0 | -2 | - | - | - | - | - | - |
Comprehensive loss | ||||||||||
-8,357 | -4,927 | -15,667 | -21,073 | -20,906 | - | - | - | - | - | - |
Foreign currency translation adjustment | ||||||||||
- | - | - | - | - | -1 | 7 | 0 | 0 | - | - |
Comprehensive loss | ||||||||||
- | - | - | - | - | -22,629 | -19,824 | -10,121 | -12,518 | - | - |
Weighted average common shares outstanding - basic and diluted | ||||||||||
- | - | - | - | - | - | - | - | - | 43,466 | 34,280 |