| Dec'18 | Dec'17 | Dec'16 | Dec'15 | Dec'14 | ||
|---|---|---|---|---|---|---|
Cash flows from operating activities | ||||||
Net loss | ||||||
-221,540 | -303,261 | -89,084 | -78,399 | -31,875 | ||
Adjustments to reconcile net loss to net cash used in operating activities: | ||||||
Depreciation and amortization | ||||||
555 | 339 | 123 | 72 | 64 | ||
Stock-based compensation | ||||||
29,843 | 20,703 | 11,003 | 5,132 | 1,643 | ||
Acquired in-process research and development | ||||||
891 | 128,555 | - | - | - | ||
Amortization of discount for payments related to acquired in-process research and development | ||||||
4,839 | 1,606 | - | - | - | ||
Loss on disposal of property and equipment | ||||||
- | - | - | - | -7 | ||
Net (accretion) amortization of premiums on available-for-sale securities | ||||||
475 | -2,366 | -1,879 | -2,012 | -190 | ||
Amortization of debt discount and issuance costs | ||||||
1,872 | 1,143 | - | - | - | ||
Revaluation of convertible preferred stock warrant liability | ||||||
- | - | - | - | 78 | ||
Common stock issued in connection with license agreement | ||||||
- | 523 | 1,453 | - | - | ||
Impairment of intangible assets | ||||||
1,126 | - | - | 2,394 | - | ||
Loss on extinguishment of debt | ||||||
- | - | - | -124 | - | ||
Changes in assets and liabilities: | ||||||
Trade and other receivables, net | ||||||
5,672 | -21,348 | 21,400 | - | - | ||
Collaboration receivables from a related party | ||||||
- | - | - | - | 7,300 | ||
Collaboration receivables | ||||||
- | - | - | -7,300 | - | ||
Inventory | ||||||
8,370 | - | - | - | - | ||
Prepaid expenses and other current assets | ||||||
1,498 | -6,233 | 6,838 | 1,219 | 572 | ||
Other assets | ||||||
2,195 | -485 | -90 | -395 | 1,207 | ||
Accounts payable | ||||||
823 | 1,542 | 4,266 | 3,607 | 3,209 | ||
Accrued liabilities | ||||||
-2,821 | 7,573 | 454 | 10,395 | 4,328 | ||
Refund liability | ||||||
-10,000 | 10,000 | - | - | - | ||
Other long-term liabilities | ||||||
97 | 423 | 128 | 367 | - | ||
Deferred revenue | ||||||
-379 | -3,541 | 23,815 | - | - | ||
Deferred taxes | ||||||
194 | - | - | 622 | -31 | ||
Net cash used in operating activities | ||||||
-213,098 | -103,963 | -74,111 | -48,442 | -31,404 | ||
Cash flows from investing activities | ||||||
Purchases of available-for-sale securities | ||||||
319,940 | 302,432 | 252,175 | 60,276 | 109,324 | ||
Maturities of available-for-sale securities | ||||||
363,328 | 278,580 | 122,640 | 57,875 | - | ||
Acquisition of in-process research and development | ||||||
56,000 | 80,000 | - | - | - | ||
Purchase of property and equipment | ||||||
616 | 278 | 753 | 202 | 156 | ||
Net cash used in investing activities | ||||||
-13,228 | -104,130 | -130,288 | -2,603 | -109,480 | ||
Net proceeds from issuance of convertible preferred stock | ||||||
- | - | - | - | 53,825 | ||
Net proceeds from issuance of common stock in connection with equity financing | ||||||
- | 181,538 | 135,907 | 104,047 | 120,273 | ||
Net proceeds from term loan | ||||||
33,235 | - | - | - | - | ||
Net proceeds from issuance of convertible notes | ||||||
- | 278,246 | - | - | - | ||
Payment to extinguish term loan | ||||||
- | - | - | 2,120 | - | ||
Net proceeds from issuance of common stock in connection with equity awards | ||||||
2,146 | 2,739 | 3,043 | 1,002 | - | ||
Net cash provided by financing activities | ||||||
35,381 | 462,523 | 138,950 | 102,929 | 174,098 | ||
Net decrease in cash and cash equivalents and restricted cash | ||||||
-190,945 | 254,430 | -65,449 | 51,884 | 33,214 | ||
Supplemental disclosure of cash flow information | ||||||
Interest paid | ||||||
8,928 | 4,289 | - | 123 | 117 | ||
Supplemental disclosure of noncash investing activities | ||||||
Acquisition of in-process research and development | ||||||
891 | 48,555 | - | - | - | ||
Conversion of preferred stock into common stock | ||||||
- | - | - | - | 113,413 | ||
Reclassification of preferred stock warrant liability into additional paid-in-capital | ||||||
- | - | - | - | 139 | ||
Acquisition of property and equipment under accounts payable and accrued liabilities | ||||||
5 | 367 | 111 | 50 | 32 | ||