| Sep'19 | Jun'19 | Mar'19 | Dec'18 | Sep'18 | Jun'18 | Mar'18 | Dec'17 | Sep'17 | Jun'17 | Mar'17 | Dec'16 | Sep'16 | Jun'16 | Mar'16 | Dec'15 | Sep'15 | Jun'15 | Mar'15 | Dec'14 | Sep'14 | Jun'14 | Mar'14 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Cash flows from operating activities | ||||||||||||||||||||||
Net loss | ||||||||||||||||||||||
-57,621 | -17,962 | -64,832 | -71,810 | -66,544 | -23,932 | -59,254 | -56,012 | -179,174 | -38,566 | -29,509 | -7,383 | -25,510 | -27,755 | -28,436 | -31,151 | -16,054 | -17,159 | -14,035 | -6,727 | -7,847 | -8,762 | -8,539 |
Adjustments to reconcile net loss to net cash used in operating activities: | ||||||||||||||||||||||
Depreciation and amortization | ||||||||||||||||||||||
142 | 144 | 150 | 157 | 154 | 129 | 115 | 87 | 86 | 85 | 81 | 35 | 34 | 32 | 22 | 17 | 18 | 18 | 19 | 17 | 16 | 17 | 14 |
Stock-based compensation | ||||||||||||||||||||||
6,652 | 7,510 | 7,981 | 7,134 | 7,889 | 7,306 | 7,514 | 5,483 | 5,501 | 5,104 | 4,615 | 3,083 | 2,865 | 2,461 | 2,594 | 1,464 | 1,461 | 1,113 | 1,094 | 1,009 | 324 | 174 | 136 |
Amortization of discount for payments related to acquired in-process research and development | ||||||||||||||||||||||
- | - | - | 273 | 806 | 2,119 | 1,641 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - |
Net (accretion) amortization of premiums on available-for-sale securities | ||||||||||||||||||||||
744 | 682 | 583 | 519 | 313 | -77 | -280 | -427 | -597 | -732 | -610 | -612 | -479 | -376 | -412 | -497 | -534 | -526 | -455 | - | - | - | - |
Amortization of debt discount and issuance costs | ||||||||||||||||||||||
599 | 502 | 585 | 497 | 459 | 458 | 458 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - |
Amortization of operating lease right-of-use assets | ||||||||||||||||||||||
853 | 834 | 811 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - |
Revaluation of convertible preferred stock warrant liability | ||||||||||||||||||||||
- | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | 0 | 79 | 0 | -1 |
Impairment of intangible assets | ||||||||||||||||||||||
- | - | - | 0 | 0 | 0 | 1,126 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - |
Loss on disposal of assets | ||||||||||||||||||||||
0 | 0 | -101 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - |
Changes in assets and liabilities: | ||||||||||||||||||||||
Trade and other receivables, net | ||||||||||||||||||||||
-48,738 | 51,345 | 2,726 | 3,610 | 2,058 | -1 | 5 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - |
Collaboration receivables from a related party | ||||||||||||||||||||||
- | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | 0 | -7,300 | - | - | - | - |
Collaboration receivables | ||||||||||||||||||||||
- | - | - | - | - | - | - | - | - | -10,700 | -10,700 | - | - | - | - | - | - | - | - | - | - | - | - |
Inventory | ||||||||||||||||||||||
5,822 | 4,219 | 4,876 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - |
Prepaid expenses and other current assets | ||||||||||||||||||||||
-6,560 | -7,683 | 25,374 | -1,116 | -1,093 | 3,200 | 507 | -2,415 | -284 | -509 | -3,025 | 3,684 | 342 | 1,570 | 1,242 | 591 | -308 | 73 | 863 | 347 | -124 | 298 | 51 |
Other assets | ||||||||||||||||||||||
5,957 | -811 | -1,121 | 184 | 1,468 | -105 | 648 | -422 | -20 | -21 | -22 | 74 | -8 | -8 | -148 | 399 | -4 | 17 | -807 | - | - | - | - |
Accounts payable | ||||||||||||||||||||||
-302 | 5,558 | -9,873 | 2,876 | 644 | 1,654 | -4,351 | 5,301 | 1,265 | 3,070 | -8,094 | 7,280 | -2,580 | -3,744 | 3,310 | 2,443 | 1,084 | -1,140 | 1,220 | 3,253 | 517 | -568 | 7 |
Accrued liabilities | ||||||||||||||||||||||
2,997 | -1,550 | -271 | -8,702 | 7,119 | -429 | -809 | -1,934 | 10,872 | 4,233 | -5,598 | -2,055 | 2,584 | 2,490 | -2,565 | 4,397 | 5,050 | 2,062 | -1,114 | 2,546 | 858 | 76 | 848 |
Other long-term liabilities | ||||||||||||||||||||||
- | - | - | -20 | -11 | -13 | 141 | 232 | -10 | 10 | 191 | 339 | 33 | 22 | -266 | - | - | - | - | - | - | - | - |
Lease liabilities | ||||||||||||||||||||||
-877 | -859 | -841 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - |
Deferred revenue | ||||||||||||||||||||||
-1,305 | -8,585 | 30,000 | 0 | 0 | -80 | -299 | -343 | -1,066 | -1,066 | -1,066 | - | - | - | - | - | - | - | - | - | - | - | - |
Deferred taxes | ||||||||||||||||||||||
- | - | - | 0 | 0 | 0 | 194 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - |
Net cash used in operating activities | ||||||||||||||||||||||
-6,087 | -62,160 | -68,627 | -78,298 | -56,921 | -23,087 | -54,792 | -31,640 | -32,362 | -14,938 | -25,023 | 687 | -21,095 | -27,680 | -26,023 | -14,335 | -14,877 | -14,113 | -5,117 | -6,319 | -7,745 | -9,754 | -7,586 |
Cash flows from investing activities | ||||||||||||||||||||||
Purchases of available-for-sale securities | ||||||||||||||||||||||
182,134 | 120,633 | 43,189 | 61,824 | 25,115 | 184,127 | 48,874 | 76,508 | 61,323 | 109,379 | 55,222 | 57,465 | 160,926 | 2,103 | 31,681 | 18,658 | 12,757 | 5,722 | 23,139 | - | - | - | - |
Maturities of available-for-sale securities | ||||||||||||||||||||||
121,126 | 83,351 | 68,709 | 95,943 | 76,770 | 94,465 | 96,150 | 89,918 | 69,135 | 61,666 | 57,861 | 42,609 | 25,417 | 11,773 | 42,841 | 21,720 | 11,155 | 0 | 25,000 | - | - | - | - |
Purchase of property and equipment | ||||||||||||||||||||||
82 | 15 | 15 | 21 | 21 | 539 | 35 | 229 | 7 | 7 | 35 | 648 | 2 | 7 | 96 | - | - | - | - | 109 | 10 | 29 | 8 |
Net cash used in investing activities | ||||||||||||||||||||||
-61,090 | -37,297 | 25,505 | 4,098 | 25,634 | -90,201 | 47,241 | -66,819 | 7,805 | -47,720 | 2,604 | -15,504 | -135,511 | 9,663 | 11,064 | 2,940 | -1,631 | -5,773 | 1,861 | -109,433 | -10 | -29 | -8 |
Net proceeds from issuance of common stock in connection with equity financing | ||||||||||||||||||||||
1 | -355 | 140,525 | - | - | - | - | 0 | 1 | -1,006 | 182,543 | -2,089 | 1,281 | 136,627 | 88 | -521 | 104,071 | 455 | 42 | 120,266 | 0 | 5 | 2 |
Payments for debt issuance cost | ||||||||||||||||||||||
0 | 0 | 708 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - |
Net proceeds from issuance of common stock in connection with equity awards | ||||||||||||||||||||||
-165 | 1,275 | 23 | 966 | -44 | 1,027 | 197 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - |
Net cash provided by financing activities | ||||||||||||||||||||||
38,776 | 920 | 139,840 | 34,201 | -44 | 1,027 | 197 | 1,051 | -120 | 279,049 | 182,543 | 954 | 1,281 | 136,627 | 88 | -1,639 | 104,071 | 455 | 42 | 120,265 | 48,826 | 5,005 | 2 |
Net decrease in cash and cash equivalents and restricted cash | ||||||||||||||||||||||
-28,401 | -98,537 | 96,718 | -39,999 | -31,331 | -112,261 | -7,354 | -97,408 | -24,677 | 216,391 | 160,124 | -13,863 | -155,325 | 118,610 | -14,871 | -13,034 | 87,563 | -19,431 | -3,214 | 4,513 | 41,071 | -4,778 | -7,592 |
Supplemental disclosure of noncash investing activities | ||||||||||||||||||||||