| Dec'18 | Dec'17 | Dec'16 | Dec'15 | Dec'14 | Dec'13 | Dec'12 |
|---|---|---|---|---|---|---|
Revenue: | ||||||
Collaboration revenue from a related party | ||||||
- | - | - | - | 7,300 | - | - |
Total revenue | ||||||
42,339 | 4,541 | 22,585 | 7,300 | 7,300 | - | - |
Costs and operating expenses: | ||||||
Cost of sales | ||||||
1,176 | - | - | - | - | - | - |
Research and development | ||||||
80,547 | 104,409 | 83,166 | 66,831 | 30,710 | 17,937 | 17,055 |
Acquired in-process research and development | ||||||
891 | 128,555 | - | - | - | - | - |
Selling, general and administrative | ||||||
172,581 | 71,903 | 30,043 | 17,721 | 8,288 | 4,366 | 3,148 |
Impairment of intangible assets | ||||||
1,126 | - | - | 2,394 | - | - | - |
Total costs and operating expenses | ||||||
256,321 | 304,867 | 113,209 | 86,946 | 38,998 | 22,303 | 20,203 |
Loss from operations | ||||||
-213,982 | -300,326 | -90,624 | -79,646 | -31,698 | -22,303 | -20,203 |
Interest and other income, net | ||||||
7,887 | 5,205 | 1,540 | 896 | 7 | -38 | -51 |
Interest expense | ||||||
15,639 | 8,140 | - | 147 | 153 | 9 | - |
Loss on extinguishment of debt | ||||||
- | - | - | -124 | - | - | - |
Loss before taxes | ||||||
-221,734 | -303,261 | -89,084 | -79,021 | -31,844 | -22,350 | -20,254 |
Benefit for income taxes | ||||||
-194 | 0 | 0 | -622 | 31 | 0 | 0 |
Net loss | ||||||
-221,540 | -303,261 | -89,084 | -78,399 | -31,875 | -22,350 | -20,254 |
Net loss per share, basic and diluted | ||||||
-5.27 | -7.48 | -2.70 | -2.93 | -4.96 | -27.03 | -27.99 |
Weighted-average common shares used to compute net loss per share, basic and diluted | ||||||
42,003 | 40,562 | 33,045 | 26,727 | 6,426 | 826 | 723 |
Product Sales | ||||||
Total revenue | ||||||
2,960 | - | - | - | - | - | - |
Collaboration and License Revenue | ||||||
Total revenue | ||||||
39,379 | 4,541 | - | - | - | - | - |